9-Me-BC (9-Methyl-β-Carboline) is a novel methylated heterocyclic β-carboline research compound engineered for dopaminergic neurogenesis and cognitive recovery assays. By upregulating Tyrosine Hydroxylase (TH) expression and stimulating neurite outgrowth in midbrain dopaminergic neurons, 9-Me-BC enhances dopamine synthesis and mitochondrial electron transport chain efficiency.
$64.00
In stock
| Quantity | Discounted Price |
|---|---|
| 3 - 5 | $60.80 |
| 6 - 8 | $59.52 |
| 9 + | $57.60 |
9-Me-BC (known chemically as 9-Methyl-β-carboline or 9-methylpyrido[3,4-b]indole) is a synthetic methylated derivative of the heterocyclic β-carboline family. Recognized as one of the few research compounds capable of inducing true dopaminergic neurogenesis, 9-Me-BC operates by upregulating neurotrophic factors, stimulating neurite arborization, and increasing the catalytic activity of Tyrosine Hydroxylase (TH) in primary midbrain cell cultures.
Batch-verified for high analytical purity at Modern Aminos (Catalog SKU: C-002), 9-Me-BC is supplied in a pre-measured 15MG dry-fill oral capsule format (60 units per bottle). Researchers studying catecholaminergic recovery, mitochondrial respiration, and synaptic structural remodeling utilize 9-Me-BC to evaluate dopaminergic pathway restoration alongside related neurotrophic reference standards available on the site, such as Bromantane, NSI-189 Phosphate, and PRL-8-53.
| Compound Name | 9-Me-BC (9-Methyl-β-Carboline) |
|---|---|
| Quantity / Formats Offered | 15MG Dry-Fill Capsules (60 Units per Bottle) |
| SKU / MPN | C-002 / C-002 |
| Synonyms / Alt Names | 9-Methyl-9H-β-carboline, 9-methylpyrido[3,4-b]indole, 9-Me-BC |
| CAS Number | 2521-01-9 |
| Chemical Formula | C12H10N2 |
| Molecular Weight | 182.22 g/mol |
| IUPAC Name | 9-methylpyrido[3,4-b]indole |
| InChIKey | AOWBJSJECJRFMV-UHFFFAOYSA-N |
| SMILES Code | CN1C2=CC=CC=C2C3=C1C=CN=C3 |
The biochemical pathways and cellular targets of 9-Me-BC in laboratory research include:
When evaluating research efficacy and published scientific literature for 9-Me-BC (9-Methyl-β-Carboline):
To evaluate neurotransmitter targets, neuroplasticity cascades, and neuro-regenerative capacity, researchers compare 9-Me-BC against alternative cognitive reference compounds available at Modern Aminos:
| Compound / Reference | Primary Class / Target | Core Mechanism of Action | Research Profile & Focus |
|---|---|---|---|
| 9-Me-BC (C-002) | Methylated β-Carboline / Dopaminergic Neurogenesis Agent | Upregulates Tyrosine Hydroxylase (TH) gene expression, drives neurite outgrowth, and boosts mitochondrial Complex I activity | Focuses on structural restoration of dopaminergic neurons, neurite arborization, and dopamine synthesis recovery |
| Bromantane | Adamantane Actoprotector / TH Upregulator | Upregulates Tyrosine Hydroxylase gene expression while modulating central GABAergic neurotransmission | Focuses on non-depleting dopamine production, physical endurance, and non-sedating anxiolysis without direct neurite outgrowth induction |
| NSI-189 Phosphate | Benzylpiperazine Aminopyridine Neurogenic Compound | Stimulates neurogenesis and synaptic expansion in the hippocampal subgranular zone (SGZ) | Focuses on hippocampal volume recovery and dentate gyrus neurogenesis rather than midbrain dopaminergic system repair |
| PRL-8-53 | Substituted Benzoic Acid Derivative | Potentiates cholinergic neurotransmission and modulates central monoaminergic signaling | Focuses on rapid verbal memory acquisition, short-term recall consolidation, and acute cognitive task execution |
Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and reference compounds. Every batch of 9-Me-BC (SKU: C-002) undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ purity, correct molecular weight (182.22 g/mol), and complete absence of unreacted synthetic impurities or heavy metals.
9-Me-BC is a methylated heterocycle belonging to the β-carboline family. Its primary structural feature is a methyl group substituted at the N9 position of the indole ring. It targets transcription factors (Nurr1, Pitx3) and enzymes (Tyrosine Hydroxylase) involved in dopaminergic neuron differentiation and maintenance.
9-Me-BC acts as a neurotrophic signal that promotes the proliferation, differentiation, and survival of dopaminergic precursor cells. In primary mesencephalic cultures, exposure to 9-Me-BC triggers neurite outgrowth and increases the density of TH-positive neurons.
Tyrosine Hydroxylase is the rate-limiting enzyme in catecholamine biosynthesis. Research shows that 9-Me-BC upregulates mRNA expression of TH and its associated transcription factors, expanding the enzymatic machinery available to convert L-tyrosine into L-DOPA and dopamine.
Modern Aminos provides 9-Me-BC in pre-measured 15MG dry-fill solid capsules (60 units per bottle). This format ensures precise unit-mass handling for solid-state laboratory assays, preventing weighing errors and eliminating solution handling variance.
While both compounds increase Tyrosine Hydroxylase expression, Bromantane is an actoprotector that pairs TH upregulation with GABAergic stress buffering. 9-Me-BC is a structural β-carboline that specifically drives neurite outgrowth, synaptogenesis, and mitochondrial Complex I respiratory efficiency in dopaminergic cells.
9-Me-BC enhances mitochondrial Complex I (NADH dehydrogenase) electron transport efficiency. By boosting mitochondrial respiratory chain output and reducing cellular oxidative stress, 9-Me-BC helps preserve neuronal viability during exposure to neurotoxic insults.
Bottles containing dry-fill 9-Me-BC capsules should be kept tightly sealed in a cool, dry environment (15°C to 25°C) away from direct sunlight, excess heat, and humidity. Stored under controlled room conditions, 9-Me-BC maintains full chemical stability throughout its designated shelf life.
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