Bromantane (Ladasten / ADK-709 / N-(4-bromophenyl)adamantan-2-amine) is a synthetic polyhedral adamantane derivative classified in Russian literature as an atypical actoprotector and anxiolytic reference standard. Operating through genomic and enzymatic upregulation, Bromantane stimulates the transcriptional expression of Tyrosine Hydroxylase (TH) and aromatic L-amino acid decarboxylase (AAAD), accelerating de novo dopamine and catecholamine biosynthesis in hypothalamic neuronal assays.
$49.00
| Quantity | Discounted Price |
|---|---|
| 4 - 6 | $47.04 |
| 7 - 9 | $46.06 |
| 10 + | $45.08 |
Bromantane (known chemically as Ladasten, ADK-709, or N-(4-bromophenyl)adamantan-2-amine) is a synthetic adamantane derivative classified as an actoprotector—a unique category of non-depleting metabolic adaptogens engineered to sustain physical and cognitive capacity without increasing oxygen consumption or provoking hyperstimulation.
Unlike conventional central nervous system psychostimulants that function by forcing reverse-transporter monoamine release or competitive reuptake transporter blockade, Bromantane operates through an indirect genomic mechanism. In cellular and neurochemical models, it upregulates the gene transcription and protein expression of Tyrosine Hydroxylase (TH) and aromatic L-amino acid decarboxylase (AAAD) across the striatum, hypothalamus, and ventral tegmental area. Because Tyrosine Hydroxylase represents the rate-limiting enzyme in catecholamine biosynthesis, this transcriptional drive accelerates de novo dopamine and norepinephrine generation while preserving intracellular vesicular stores.
Simultaneously, Bromantane exhibits a distinct anxiolytic profile mediated by the facilitation of central GABAergic transmission and the suppression of GABA transporter clearance mechanisms. This dual catecholaminergic-GABAergic mechanism produces alertness and endurance while maintaining resistance against excitotoxic stress and hyperactive adrenergic cascades.
Batch-verified for high analytical purity and mass calibration at Modern Aminos, Bromantane is offered in two standardized laboratory configurations: pre-measured **25MG dry-fill solid capsules (60 units per bottle)** and a stable **50MG/ML analytical liquid solution (30ML bottle)**. Researchers evaluating catecholaminergic enzyme kinetics, actoprotective bioenergetics, and synaptic neuroplasticity study Bromantane alongside complementary reference standards available on the site, such as Phenylpiracetam Hydrazide, Noopept, Sunifiram, and L-THP.
| Compound Name | Bromantane (Ladasten / ADK-709) |
|---|---|
| Available Formats | 25MG Dry-Fill Solid Capsules (60 Count) & 50MG/ML Liquid Solution (30ML) |
| Biological Target | Central Nervous System / Tyrosine Hydroxylase (TH) Transcription & GABAergic Modulatory Networks |
| Chemical Classification | Synthetic Adamantane Derivative / Polyhedral Actoprotector |
| Synonyms / Alt Names | Bromantan, Ladasten, ADK-709, N-(2-Adamantyl)-N-(4-bromophenyl)amine, 2-(4-bromoanilino)adamantane |
| CAS Number | 87913-26-6 |
| Chemical Formula | C16H20BrN |
| Molecular Weight | 306.24 g/mol |
| IUPAC Name | N-(4-bromophenyl)adamantan-2-amine |
| InChIKey | InChIKey=LWJALJDRFBXHKX-UHFFFAOYSA-N |
| SMILES Code | C1C2CC3CC1CC(C2)C3NC4=CC=C(C=C4)Br |
The biochemical pathways and cellular targets of Bromantane (Ladasten) in laboratory research include:
When evaluating published scientific literature and neurochemical monographs for Bromantane (Ladasten):
In neurochemical, cognitive, and psychostimulatory research, compounds differ substantially in their molecular targets, receptor kinetics, and metabolic outcomes:
| Compound / Reference | Chemical Structure & Class | Primary Mechanistic Target | Primary Research Focus |
|---|---|---|---|
| Bromantane | Synthetic Adamantane Derivative | Upregulates Tyrosine Hydroxylase (TH) transcription & GABA facilitation | De novo dopamine synthesis, non-depleting actoprotection, and anxiolytic resilience |
| Phenylpiracetam Hydrazide | Phenylated Pyrrolidone Hydrazide | AMPA positive allosteric modulation & high-affinity choline uptake | Rapid membrane diffusion, glutamatergic synaptic plasticity, and cholinergic kinetics |
| Noopept | Cycloprolylglycine Dipeptide Ester | AMPA/NMDA receptor modulation & hippocampal BDNF/NGF upregulation | Synaptogenesis, neurotrophin expression, and memory consolidation modeling |
| Sunifiram | Piperazine Ampakine Derivative | AMPA allosteric activation & CaMKII / PKCα phosphorylation | Ultra-high-potency glutamatergic long-term potentiation (LTP) and acetylcholine release |
Yes, Modern Aminos is a highly trusted vendor for analytical research chemicals and neurochemical standards. Every batch undergoes strict third-party analytical verification (including HPLC and High-Resolution Mass Spectrometry) to confirm minimum 98%+ active chemical purity, verified molecular weight (306.24 g/mol), exact volumetric or gravimetric fill calibration, and the complete absence of heavy metals or synthesis impurities.
Bromantane (Ladasten / ADK-709) is a synthetic adamantane derivative chemically designated as N-(4-bromophenyl)adamantan-2-amine. It belongs to the actoprotector class of compounds, designed to support physical and mental work capacity through genomic and metabolic adaptation.
Bromantane stimulates the gene transcription and protein expression of Tyrosine Hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis. This genomic upregulation increases cellular L-DOPA and dopamine production without triggering rapid intracellular neurotransmitter depletion.
Bromantane facilitates central GABAergic neurotransmission and suppresses GABA transporter expression, strengthening inhibitory tone. This unique dual mechanism offsets dopamine-induced hyperstimulation, providing focused vigilance without anxiety, tremor, or restlessness.
Modern Aminos offers Bromantane in two calibrated formats: pre-measured 25MG dry-fill solid capsules (60 count bottle) for gravimetric precision, and a stabilized 50MG/ML analytical liquid solution (30ML bottle) for precise volumetric liquid handling in laboratory assays.
The research suggests that:
Modern Aminos utilizes High-Performance Liquid Chromatography (HPLC) to verify active compound purity exceeding 98% and High-Resolution Mass Spectrometry (HRMS) to confirm the exact molecular weight (306.24 g/mol) and adamantane fragmentation pattern prior to batch release.
Both Bromantane capsule bottles and liquid solution bottles should be stored tightly sealed in a cool, dry environment (15°C to 25°C) protected from direct sunlight, thermal extremes, and atmospheric moisture to preserve solid-phase and carrier solution stability.
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