What Is ATX-304? O-304 (Pan-AMPK Activator) Explained

October 28, 2026

What Is ATX-304? O-304 (Pan-AMPK Activator) Explained
View ATX-304 Product Page

What Is ATX-304?

Short answer: ATX-304 is the research code for O-304, a small-molecule AMP-activated protein kinase (AMPK) activator. PubChem CID 50923806 lists formula C16H11Cl2N3O2S, molecular weight 380.2 g/mol, and depositor synonym CAS 1261289-04-6. To buy ATX-304 as a documented research format, see the product page.

What is ATX-304, chemically speaking?

Direct answer: O-304 is a dichlorinated benzamide linked to a 1,2,4-thiadiazol-5-yl ring — a non-nucleoside chemotype, not a peptide and not AICAR. PubChem records the IUPAC name 4-chloro-N-[2-[(4-chlorophenyl)methyl]-3-oxo-1,2,4-thiadiazol-5-yl]benzamide and InChIKey WEDWLYRQKUTOAX-UHFFFAOYSA-N.

ATX-304 (O-304) 2D chemical structure, PubChem CID 50923806 at modern aminos the most trusted supplier of research peptides in the USA
2D structure of ATX-304 (O-304). Image: PubChem, CID 50923806 (National Library of Medicine).

Is ATX-304 a peptide or a nucleoside?

Direct answer: No. ATX-304 / O-304 is a small molecule. It contains no amino-acid polymer backbone and is not a nucleoside analog like AICAR. Confusing it with peptides or with AICAR mixes unrelated chemotypes that happen to sit in the same AMPK research niche.

How does O-304 relate to AMPK?

Direct answer: Peer-reviewed papers describe ATX-304 / O-304 as an AMPK activator used in metabolic biochemistry studies (PMID 40197369; PMID 38749175). AMPK is a heterotrimeric energy-sensing kinase; activator tools are used to probe that pathway in controlled assays. Interpretation: treat “pan-AMPK activator” as the design class reported in those papers, and take any EC50 or isoform-selectivity numbers only from the assay table of the cited source — not from marketing copy.

Published numbers at a glance

Item Detail Source
CAS (depositor synonym) 1261289-04-6 PubChem
Formula C16H11Cl2N3O2S PubChem
Molecular weight 380.2 g/mol PubChem
InChIKey WEDWLYRQKUTOAX-UHFFFAOYSA-N PubChem
Design class Non-nucleoside AMPK activator PMID 40197369; 38749175

What this tells us: ATX-304 is a compact chlorinated heterocycle with a defined PubChem record. Identity claims should start from CAS, InChIKey and CID before any pathway story.

ATX-304 vs AICAR: what’s the actual difference?

Direct answer: Both are used as AMPK-pathway tools, but the structures differ. AICAR is a nucleoside analog that is converted to ZMP inside cells; O-304 is a thiadiazolone benzamide that does not share that nucleoside scaffold. Comparing “activator potency” across papers without matching assay conditions is not valid chemistry.

What formats is ATX-304 supplied in for research?

All applicable tests are performed on our products. See the ATX-304 (O-304) product page Certificate of Analysis tab when certificates are posted, and COA Search for lot lookup. No fill amounts are restated here.

Related references: BAM15 (mitochondrial uncoupler), cardarine (PPAR-δ), and the SR-9009 (stenabolic) Rev-Erb companion post.

Frequently asked questions

What is ATX-304 (O-304)?

ATX-304 is the research code for O-304, a small-molecule AMP-activated protein kinase (AMPK) activator. PubChem CID 50923806 lists formula C16H11Cl2N3O2S, molecular weight 380.2 g/mol, and depositor synonym CAS 1261289-04-6.

Is ATX-304 a peptide?

No. ATX-304 / O-304 is a dichlorinated benzamide–thiadiazolone small molecule, not an amino-acid polymer.

How does O-304 relate to AMPK?

Primary research papers describe ATX-304 / O-304 as an AMPK activator used in metabolic biochemistry studies (PMID 40197369; PMID 38749175). Quantitative EC50 or isoform panels should be taken from each paper assay table.

How does ATX-304 differ from AICAR?

AICAR is a nucleoside analog AMPK activator classically used as a prodrug of ZMP. O-304 is a distinct non-nucleoside chemotype (thiadiazolone benzamide). They share an AMPK-pathway research niche, not the same structure.

How is ATX-304 verified at Modern Aminos?

All applicable tests are performed on our products. Certificates appear in the Certificate of Analysis tab when posted; use COA Search for lot lookup.

References

  1. Primary literature describing ATX-304 / O-304 as an AMPK activator. PMID 40197369.
  2. Primary literature describing ATX-304 / O-304 AMPK-activator context. PMID 38749175.
  3. National Center for Biotechnology Information. PubChem CID 50923806. pubchem.ncbi.nlm.nih.gov/compound/50923806.

For documented laboratory formats, open the ATX-304 product page.

DISCLAIMER: All compounds and research materials provided by Modern Aminos are strictly for laboratory and research use only. They are not approved for human consumption by the Food and Drug Administration (FDA). No products are approved for oral, sublingual, nor in vivo use. These products should not be used for any form of in vivo experimentation or for any other non-laboratory purpose. Any violation or indication of human or animal use will result in immediate removal from being able to purchase products in the future. By purchasing these products, you acknowledge that they will be used exclusively within a controlled and qualified research environment.
0