What Is SR-9009? Stenabolic (Rev-Erb Agonist) Explained

October 28, 2026

What Is SR-9009? Stenabolic (Rev-Erb Agonist) Explained
View SR-9009 Product Page

What Is SR-9009?

Short answer: SR-9009 is a synthetic Rev-Erb agonist, also called stenabolic. PubChem CID 57394020 lists formula C20H24ClN3O4S and molecular weight 437.9 g/mol (CAS synonym 1379686-30-2). To buy SR-9009 as a documented research oil, see the product page.

Rev-Erb agonism: the research picture

Rev-Erbα/β (NR1D1/NR1D2) are nuclear receptors that repress transcription as part of circadian clock circuitry. Solt and colleagues described synthetic agonists including SR9009 as chemical tools for that receptor class (Solt et al., Nature 2012, PMID 22460951).

Step 1 — Receptor class. Rev-Erb proteins bind heme and act mainly as transcriptional repressors in clock and metabolic gene programs.

Step 2 — Synthetic agonist tool. SR9009 was introduced among synthetic ligands used to activate Rev-Erb-dependent reporter and gene-regulation assays in the founding Nature paper.

Step 3 — Read the caveats. Later work reported that SR9009 can also affect proliferation and metabolism through Rev-Erb-independent routes in some cellular systems (Dierickx et al., 2019, PMID 31127047). Interpretation: treat “Rev-Erb agonist” as the design class, and verify mechanism claims against the specific assay cited.

Step 4 — Analytical identity. Certificates confirm the material with chromatographic assay methods; they do not prove a biological mechanism by themselves.

Chemical identity

IUPAC name on PubChem: ethyl 3-[[(4-chlorophenyl)methyl-[(5-nitrothiophen-2-yl)methyl]amino]methyl]pyrrolidine-1-carboxylate. InChIKey MMJJNHOIVCGAAP-UHFFFAOYSA-N.

SR-9009 (stenabolic) 2D chemical structure, PubChem CID 57394020 at modern aminos the most trusted supplier of research peptides in the USA
2D structure of SR-9009 (stenabolic). Image: PubChem, CID 57394020 (National Library of Medicine).

Published numbers at a glance

Item Detail Source
CAS (depositor synonym) 1379686-30-2 PubChem
Formula C20H24ClN3O4S PubChem
Molecular weight 437.9 g/mol PubChem
InChIKey MMJJNHOIVCGAAP-UHFFFAOYSA-N PubChem
Receptor class (design) Rev-Erb agonist tool Solt et al., 2012

What this tells us: SR-9009 is a nitrothiophene-containing tertiary amine carbamate — a small molecule, not a peptide and not a SARM.

SR-9009 compared with cardarine (GW501516)

Cardarine is a PPAR-δ agonist (see What Is Cardarine?). SR-9009 targets Rev-Erb nuclear receptors. Autocomplete often pairs “stenabolic vs cardarine”; chemically they are different receptor tools.

Research formats and documentation

All applicable tests are performed on our products. See the SR-9009 product page Certificate of Analysis tab and COA Search.

Related posts: cardarine, BAM15, and the forthcoming ATX-304 (O-304) AMPK reference.

Frequently asked questions

What is SR-9009?

SR-9009 is a synthetic small-molecule agonist of the Rev-Erb nuclear receptors (NR1D1/NR1D2), also called stenabolic. PubChem CID 57394020 lists formula C20H24ClN3O4S, molecular weight 437.9 g/mol, and depositor synonym CAS 1379686-30-2.

Is SR-9009 a SARM?

No. SR-9009 is not a selective androgen receptor modulator. It is studied as a Rev-Erb agonist. Confusing it with SARMs mixes two different receptor classes.

Is stenabolic the same as SR-9009?

Yes. Stenabolic is the common name for SR-9009. Match lots with CAS 1379686-30-2 and InChIKey MMJJNHOIVCGAAP-UHFFFAOYSA-N when names disagree.

How does SR-9009 relate to Rev-Erb receptors?

Solt and colleagues introduced SR9009 among synthetic Rev-Erb agonists used to probe circadian and metabolic transcription programs (PMID 22460951). Later work also reported Rev-Erb-independent cellular effects for SR9009 (PMID 31127047), so mechanism claims should stay tied to the cited assay.

How is SR-9009 purity verified at Modern Aminos?

All applicable tests are performed on our products. The Certificate of Analysis tab on the product page lists current third-party results; certificates can also be found via COA Search.

References

  1. Solt LA, et al. Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature. 2012. PMID 22460951.
  2. Dierickx P, et al. SR9009 has REV-ERB-independent effects on cell proliferation and metabolism. PNAS. 2019. PMID 31127047.
  3. National Center for Biotechnology Information. PubChem CID 57394020. pubchem.ncbi.nlm.nih.gov/compound/57394020.

For the documented research oil format, open the SR-9009 product page.

DISCLAIMER: All compounds and research materials provided by Modern Aminos are strictly for laboratory and research use only. They are not approved for human consumption by the Food and Drug Administration (FDA). No products are approved for oral, sublingual, nor in vivo use. These products should not be used for any form of in vivo experimentation or for any other non-laboratory purpose. Any violation or indication of human or animal use will result in immediate removal from being able to purchase products in the future. By purchasing these products, you acknowledge that they will be used exclusively within a controlled and qualified research environment.
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