What Is Dihexa? PNB-0408 (Hexanoyl-Tyr-Ile-Ahx-NH2) Explained

October 28, 2026

What Is Dihexa? PNB-0408 (Hexanoyl-Tyr-Ile-Ahx-NH2) Explained
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What Is Dihexa?

Short answer: Dihexa (PNB-0408) is a synthetic oligopeptide related to an Angiotensin IV fragment, chemically described as hexanoyl-Tyr-Ile-Ahx-NH2. PubChem CID 129010512 lists formula C27H44N4O5, molecular weight 504.7 g/mol, and CAS 1401708-83-5. To buy dihexa as a documented research peptide, see the product page.

Quick answers

What is dihexa?

Dihexa (PNB-0408) is a synthetic oligopeptide derived from an Angiotensin IV fragment, chemically described as hexanoyl-Tyr-Ile-Ahx-NH2. PubChem CID 129010512 lists formula C27H44N4O5, molecular weight 504.7 g/mol, and CAS 1401708-83-5.

Is dihexa a peptide?

Yes. Dihexa is a short synthetic peptide (an oligopeptide) with a hexanoyl N-cap, a Tyr-Ile core, and a 6-aminohexanoic amide tail. It is not a small-molecule SARM or a classic large protein.

What is PNB-0408?

PNB-0408 is a synonym for dihexa on chemical directories and certificates. Prefer CAS 1401708-83-5 and InChIKey XEUVNVNAVKZSPT-JTJYXVOQSA-N when reconciling names, including the misspelling digexa.

What is dihexa, chemically speaking?

Direct answer: Dihexa is a short capped peptide: an N-hexanoyl tyrosine–isoleucine core extended with 6-aminohexanoic amide. It is an oligopeptide, not a small-molecule SARM and not a large protein. InChIKey XEUVNVNAVKZSPT-JTJYXVOQSA-N anchors stereochemistry on directory records.

Dihexa (PNB-0408) 2D chemical structure, PubChem CID 129010512 at modern aminos the most trusted supplier of research peptides in the USA
2D structure of dihexa (PNB-0408). Image: PubChem, CID 129010512 (National Library of Medicine).

Is dihexa a peptide?

Direct answer: Yes. Dihexa is a synthetic oligopeptide. Searchers often ask this to separate it from small-molecule nootropics; the answer is structural — amide-linked amino-acid derivatives with a fatty-acid N-cap — not a marketing category.

PNB-0408, dihexa and other names

Direct answer: PNB-0408 is a synonym for dihexa on chemical directories and certificates. Match lots with CAS 1401708-83-5 and PubChem CID 129010512 rather than trade-name variants alone.

What about retracted dihexa papers?

Direct answer: Some widely circulated dihexa papers are retracted, including work indexed as a retracted publication. Do not treat retracted findings as established fact. Rely on PubChem identity and non-retracted primary sources for any mechanism claim. This post does not summarize retracted outcome claims.

Published numbers at a glance

Item Detail Source
CAS 1401708-83-5 PubChem
Formula C27H44N4O5 PubChem
Molecular weight 504.7 g/mol PubChem
InChIKey XEUVNVNAVKZSPT-JTJYXVOQSA-N PubChem
Synonyms PNB-0408; hexanoyl-Tyr-Ile-Ahx-NH2 PubChem / literature

What this tells us: Dihexa has a clean directory identity. Mechanism stories that depend on retracted papers should be dropped or replaced with non-retracted citations before use in documentation.

What formats is dihexa supplied in for research?

All applicable tests are performed on our products. A Vanguard Laboratory certificate reports chromatographic purity by HPLC-UV/VIS as printed in the Certificate of Analysis tab on the dihexa product page; lots can also be found via COA Search.

For other documented research compounds on Modern Aminos, see related public references such as TAK-653, bromantane and GB-115 posts when available, plus the bioregulator comparison post for short-peptide identity work.

Frequently asked questions

What is dihexa?

Dihexa (PNB-0408) is a synthetic oligopeptide derived from an Angiotensin IV fragment, chemically described as hexanoyl-Tyr-Ile-Ahx-NH2. PubChem CID 129010512 lists formula C27H44N4O5, molecular weight 504.7 g/mol, and CAS 1401708-83-5.

Is dihexa a peptide?

Yes. Dihexa is a short synthetic peptide (an oligopeptide) with a hexanoyl N-cap, a Tyr-Ile core, and a 6-aminohexanoic amide tail. It is not a small-molecule SARM or a classic large protein.

What is PNB-0408?

PNB-0408 is a synonym for dihexa on chemical directories and certificates. Prefer CAS 1401708-83-5 and InChIKey XEUVNVNAVKZSPT-JTJYXVOQSA-N when reconciling names.

What should researchers know about retracted dihexa papers?

Some widely circulated dihexa papers are retracted, including work indexed as a retracted publication. Do not treat retracted findings as established fact. Rely on directory identity (PubChem) and non-retracted primary sources for any mechanism claim.

How is dihexa verified at Modern Aminos?

All applicable tests are performed on our products. A Vanguard Laboratory certificate for dihexa raw powder reports chromatographic purity by HPLC-UV/VIS as printed in the Certificate of Analysis tab; lots can be looked up via COA Search.

References

  1. National Center for Biotechnology Information. PubChem CID 129010512. pubchem.ncbi.nlm.nih.gov/compound/129010512.
  2. Retracted publication notice (do not use conclusions). .

For the documented research peptide format, open the dihexa product page.

DISCLAIMER: All compounds and research materials provided by Modern Aminos are strictly for laboratory and research use only. They are not approved for human consumption by the Food and Drug Administration (FDA). No products are approved for oral, sublingual, nor in vivo use. These products should not be used for any form of in vivo experimentation or for any other non-laboratory purpose. Any violation or indication of human or animal use will result in immediate removal from being able to purchase products in the future. By purchasing these products, you acknowledge that they will be used exclusively within a controlled and qualified research environment.
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