Dihexa (PNB-0408 / N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide) is a blood-brain barrier permeable oligopeptide analog derived from Angiotensin IV. Operating as a high-affinity positive allosteric modulator of Hepatocyte Growth Factor (HGF), Dihexa binds HGF to potentiate c-Met receptor tyrosine kinase signaling. This cascade stimulates robust dendritic spinogenesis and new functional synaptogenesis in neuronal models, demonstrating neurotrophic potency up to seven orders of magnitude greater than Brain-Derived Neurotrophic Factor (BDNF).
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| Quantity | Discounted Price |
|---|---|
| 3 - 5 | $89.30 |
| 6 - 8 | $87.42 |
| 9 + | $84.60 |
Dihexa (known chemically as PNB-0408, N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide, or Hexanoyl-Tyr-Ile-Ahx-NH2) is a synthetic oligopeptide derived from Nle1-Angiotensin IV. Originally engineered at Washington State University as a blood-brain barrier permeable procognitive agent, Dihexa binds with ultra-high affinity to Hepatocyte Growth Factor (HGF).
Batch-verified for purity at Modern Aminos, Dihexa is supplied as a high-purity lyophilized reference powder for laboratory screening and synaptic plasticity assays. Researchers studying neurodegenerative recovery, dendritic arborization, and growth factor receptor kinetics utilize Dihexa to evaluate c-Met activation alongside related neurotrophic and glutamatergic reference standards available on the site, such as P21, TAK-653, and Noopept.
| Compound Name | Dihexa (PNB-0408) |
|---|---|
| Format & Packaging | Analytical-Grade Lyophilized Reference Powder |
| Synonyms / Alt Names | PNB-0408, N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide, Hexanoyl-Tyr-Ile-Ahx-NH2 |
| CAS Number | 1401708-83-5 |
| Chemical Formula | C27H44N4O5 |
| Molecular Weight | 504.67 g/mol |
| IUPAC Name | 6-[(2S,3S)-2-[(2S)-2-hexanamido-3-(4-hydroxyphenyl)propanamido]-3-methylpentanamido]hexanamide |
| InChIKey | XEUVNVNAVKZSPT-JTJYXVOQSA-N |
| SMILES Code | CCCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCCCCCC(N)=O |
The biochemical pathways and cellular targets of Dihexa in laboratory research include:
When evaluating research efficacy and published scientific literature for Dihexa (PNB-0408):
To evaluate receptor targeting, synaptogenic potency, and neurotrophic pathways, researchers compare Dihexa against alternative cognitive and neuro-regenerative reference compounds available at Modern Aminos:
| Compound / Reference | Primary Target & Class | Core Mechanism of Action | Research Profile & Focus |
|---|---|---|---|
| Dihexa (PNB-0408) | Angiotensin IV Derived Oligopeptide / HGF Potentiator | Binds HGF to drive c-Met receptor dimerization, spinogenesis, and functional synaptogenesis | Ultra-potent synaptogenic compound engineered for structural neural repair, new synapse formation, and HGF pathway research |
| P21 | CNTF-Derived Synthetic Peptide Mimetic | Promotes neurogenesis and dendritic arborization via Ciliary Neurotrophic Factor (CNTF) / JAK-STAT signaling | Focuses on neurotrophic factor stimulation and neural stem cell differentiation without direct HGF/c-Met receptor binding |
| TAK-653 | AMPA Receptor Selective Positive Allosteric Modulator (PAM) | Potentiates postsynaptic AMPA currents to activate ERK/mTORC1 pathways and drive BDNF synthesis | Focuses on glutamatergic signaling, activity-dependent neuroplasticity, and rapid-onset synaptic potentiation |
| Noopept | Dipeptide-Derived Nootropic & HIF-1 Modulator | Sensitizes central AMPA/NMDA receptors and upregulates hippocampal BDNF and NGF expression | Classic cognitive research compound focused on long-term potentiation, sensory processing, and neuroprotective signaling |
Yes, Modern Aminos is a trusted supplier of high-purity research chemicals and reference peptides. Every batch of Dihexa undergoes rigorous third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 99%+ purity, exact molecular weight (504.67 g/mol), and complete absence of unreacted synthetic fragments or heavy metals.
Dihexa targets Hepatocyte Growth Factor (HGF). It binds HGF with high affinity, facilitating its interaction with the c-Met receptor tyrosine kinase. Activation of c-Met initiates downstream intracellular cascades that govern cell survival, motogenesis, and dendritic spinogenesis.
In preclinical cell culture assays measuring dendritic arborization and synaptic outgrowth, Dihexa demonstrated neurotrophic activity estimated to be up to seven orders of magnitude 1,000,000 times more potent than Brain-Derived Neurotrophic Factor (BDNF) on a molar basis.
Spinogenesis is the biological process by which neurons sprout new dendritic spines—the physical protrusions that receive synaptic inputs. Dihexa’s ability to drive spinogenesis allows researchers to study structural neural regeneration and the restoration of lost synaptic connections in damaged brain tissue models.
Lyophilized Dihexa reference powder dissolves readily in organic solvents such as dimethyl sulfoxide (DMSO) or ethanol. For biological assays, stock solutions prepared in DMSO can be diluted into sterile laboratory buffers or culture media immediately prior to application.
Dihexa is an N-hexanoylated tripeptide derived from Angiotensin IV that acts through HGF/c-Met receptor activation. P21 is an adamantane-containing synthetic peptide mimetic derived from Ciliary Neurotrophic Factor (CNTF) that operates via CNTF/JAK-STAT pathways. While both promote neural repair, they engage entirely different growth factor systems.
Yes. The N-terminal hexanoyl cap and specific hydrophobic amino acid sequence (Tyr-Ile-Ahx) were engineered specifically to increase lipophilicity and metabolic stability, allowing Dihexa to cross cell membranes and the blood-brain barrier intact in preclinical models.
Lyophilized Dihexa powder should be stored sealed in its original reagent vial at -20°C for long-term preservation. Protect from moisture, heat, and direct light exposure. Reconstituted liquid stock solutions in DMSO should be aliquoted and stored frozen to maintain chemical stability.
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