TAK-653 (Osavampator / NBI-1065845) is a novel, highly potent positive allosteric modulator (PAM) of AMPA glutamate receptors with no direct agonistic activity. By potentiating natural glutamatergic neurotransmission without triggering receptor desensitization or excitotoxicity, TAK-653 stimulates central mTORC1 signaling, activates ERK pathways, and increases Brain-Derived Neurotrophic Factor (BDNF) expression in neuronal models.
$78.00
In stock
| Quantity | Discounted Price |
|---|---|
| 3 - 5 | $74.88 |
| 7 - 10 | $73.32 |
| 9 + | $71.76 |
TAK-653 (known chemically as Osavampator, NBI-1065845, or 9-[4-(cyclohexyloxy)phenyl]-7-methyl-3,4-dihydropyrazino[2,1-c][1,2,4]thiadiazine 2,2-dioxide) is an investigational positive allosteric modulator (PAM) targeting the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. Developed as a selective glutamatergic enhancer, TAK-653 binds an allosteric pocket on the AMPA receptor complex to potentiate glutamate-induced ion channel opening without acting as a direct agonist.
Analytical batch-tested for Modern Aminos, TAK-653 is supplied as a high-purity reference aqueous solution for laboratory screening and synaptic signaling research. Researchers studying central nervous system excitability, neuroplasticity cascades, and cognitive preservation models utilize TAK-653 to evaluate AMPA receptor kinetics alongside related glutamatergic modulators available on the site, such as Sunifiram and Noopept.
| Compound Name | TAK-653 (Osavampator) |
|---|---|
| Format & Packaging | Analytical-Grade Reference Aqueous Solution in Sealed Amber Glass Reagent Vial |
| Synonyms / Alt Names | Osavampator, NBI-1065845, TAK 653, AMPA PAM TAK-653 |
| CAS Number | 1358751-06-0 |
| Chemical Formula | C19H23N3O3S |
| Molecular Weight | 373.47 g/mol |
| IUPAC Name | 9-[4-(cyclohexyloxy)phenyl]-7-methyl-3,4-dihydropyrazino[2,1-c][1,2,4]thiadiazine 2,2-dioxide |
| InChIKey | PXJBHEHFVQVDDS-UHFFFAOYSA-N |
| SMILES Code | CC1=CN(CC2)C(C(C3=CC=C(OC4CCCCC4)C=C3)=N1)=NS2(=O)=O |
The biochemical pathways and cellular targets of TAK-653 in laboratory research include:
When evaluating research efficacy and published scientific literature for TAK-653 (Osavampator):
To evaluate receptor binding kinetics, selectivity profiles, and neuroplasticity pathways, researchers compare TAK-653 against alternative glutamatergic modulators available at Modern Aminos:
| Compound / Reference | Primary Receptor Target | Core Mechanism of Action | Research Profile & Focus |
|---|---|---|---|
| TAK-653 (Osavampator) | AMPA Receptor Selective Positive Allosteric Modulator (PAM) | Potentiates glutamate-induced AMPA currents with minimal direct agonism; triggers mTORC1 and BDNF release | High-selectivity AMPA PAM engineered for neuroplasticity, dendritic spine density, and rapid-onset synaptic potentiation assays |
| Sunifiram | AMPA Receptor Positive Allosteric Modulator / Ampakine | Increases glycine-site binding affinity and stimulates presynaptic acetylcholine release | High-potency ampakine researched for acute memory consolidation and rapid synaptic transmission in learning models |
| Noopept | AMPA / NMDA Receptor Modulator & HIF-1 Peptide | Sensitizes central glutamate receptors while upregulating hippocampal BDNF and NGF expression | Dipeptide-derived neuroprotective compound focused on long-term potentiation, sensory processing, and neuro-trophin modulation |
| Aniracetam | AMPA Receptor Modulator & Cholinergic Agonist | Slows AMPA receptor desensitization and modulates metabotropic glutamate receptors (mGluRs) | Classic racetam research compound combining mild AMPA modulation with serotonergic and dopaminergic signaling |
Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and reference standards. Every batch of TAK-653 undergoes rigorous third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 99%+ purity, correct molecular weight, and complete absence of unreacted synthesis precursors or heavy metals.
TAK-653 functions as a positive allosteric modulator (PAM) at AMPA glutamate receptors. It binds a non-catalytic site on the receptor protein, stabilizing the active channel conformation when endogenous glutamate is present. This prolongs channel open time and increases sodium/calcium influx without directly activating the receptor on its own.
Direct AMPA receptor agonists can over-stimulate neurons, leading to rapid receptor desensitization, excitotoxicity, and cellular injury. Early ampakines often suffered from narrow therapeutic windows. In contrast, TAK-653 possesses virtually no direct agonistic activity, ensuring that receptor activation remains strictly dependent on natural presynaptic glutamate release.
By enhancing post-synaptic depolarization, TAK-653 triggers calcium influx that activates extracellular signal-regulated kinase (ERK) and Akt enzymes. These upstream kinase cascades stimulate mTORC1 phosphorylation, upregulating translation of Brain-Derived Neurotrophic Factor (BDNF) and promoting structural dendritic remodeling.
Minimal direct agonistic activity preserves normal physiological neurotransmission patterns. It prevents tonic, non-pulsatile receptor activation that would otherwise disrupt synaptic plasticity rhythms, trigger compensatory receptor downregulation, or induce seizure-like epileptiform activity in brain tissue assays.
TAK-653 reference aqueous solution is soluble in organic solvents such as PEG-400, DMSO, and dimethylformamide (DMF) at concentrations up to 20–30 mg/mL. It exhibits limited solubility in pure aqueous buffers. For cell culture experiments, stock solutions prepared in DMSO should be diluted into physiological saline or culture media immediately prior to use.
While Sunifiram and Noopept exhibit broad or indirect modulation of AMPA and NMDA receptor systems alongside cholinergic signaling, TAK-653 is a modern, highly targeted pharmaceutical-grade AMPA PAM specifically optimized for sub-nanomolar receptor affinity, high metabolic stability, and precise mTOR/BDNF activation.
TAK-653 solid reference powder should be stored tightly sealed in its original glass reagent vial at -20°C for long-term stability. Keep protected from moisture, heat, and direct light exposure. Solid samples stored under desiccated frozen conditions maintain full chemical stability across extended laboratory shelf lives.
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