TAK-653 (osavampator, NBI-1065845; CAS 1358751-06-0) is a small-molecule research compound, C19H23N3O3S (MW 373.5 g/mol), classified in in-vitro studies as a positive allosteric modulator of AMPA-type glutamate receptors. Modern Aminos supplies TAK-653 for laboratory research use only, with third-party HPLC testing and a QR code on every vial to search for the corresponding COA.
For research use only. Not for human or veterinary use.
Buy TAK-653 online for research: third-party tested with COA by lot number.
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| Product name | TAK-653 |
|---|---|
| Synonyms / codes | Osavampator (INN/USAN); NBI-1065845; TAK 653; TAK653 |
| CAS number | 1358751-06-0 |
| PubChem CID | 56655833 |
| UNII | 9E3TOE5RIZ |
| Molecular formula | C19H23N3O3S |
| Molecular weight | 373.5 g/mol |
| IUPAC name | 9-[4-(cyclohexyloxy)phenyl]-7-methyl-3,4-dihydropyrazino[2,1-c][1,2,4]thiadiazine 2,2-dioxide |
| InChIKey | PXJBHEHFVQVDDS-UHFFFAOYSA-N |
| SMILES | CC1=CN2CCS(=O)(=O)N=C2C(=N1)C3=CC=C(C=C3)OC4CCCCC4 |
| Compound class | Small molecule; AMPA receptor positive allosteric modulator (in-vitro classification) |
| Certificate of analysis | Batch COA: scan the QR code on the vial or search the lot number at COA Batch Search |
TAK-653 is classified as an AMPA receptor positive allosteric modulator (also called an AMPA receptor potentiator). In in-vitro receptor and cell-based assays it is described as binding an allosteric site on AMPA-type glutamate receptors and increasing glutamate-evoked receptor responses, with minimal agonistic activity when glutamate is absent. Modern Aminos supplies TAK-653 solely as a reference compound for this kind of in-vitro laboratory work.
TAK-653, also called osavampator or NBI-1065845 (CAS 1358751-06-0), is a small-molecule research compound with the formula C19H23N3O3S and a molecular weight of 373.5 g/mol. It is classified as an AMPA receptor positive allosteric modulator and is sold by Modern Aminos for laboratory research use only.
TAK-653 is also known as osavampator (its INN) and NBI-1065845, and is often written as TAK 653 or TAK653. Its CAS number is 1358751-06-0, its PubChem CID is 56655833, and its InChIKey is PXJBHEHFVQVDDS-UHFFFAOYSA-N.
TAK-653 is an AMPA receptor positive allosteric modulator, also described as an AMPA receptor potentiator. In in-vitro assays it increases glutamate-evoked AMPA receptor responses while showing minimal agonistic activity on its own.
No. TAK-653 is a small molecule (a pyrazinothiadiazine dioxide derivative, C19H23N3O3S), not a peptide. It is sometimes grouped with research peptides because peptide suppliers also carry it.
Every TAK-653 batch is tested by an independent third-party laboratory using HPLC before release. The most recent published bulk-material COA (lot TA2601A, Vanguard Laboratory, reported March 31, 2026) shows 99.25% chromatographic purity.
Match the lot number on your vial label to the lot number on the COA. Then check the compound name, the testing laboratory, the report date, the method (HPLC-UV/VIS), and the result, which is chromatographic purity for bulk material or measured concentration for finished vials. Scanning the vial’s QR code opens the matching COA.
You can buy TAK-653 for research directly from this page at Modern Aminos, a US supplier. It is sold only to qualified researchers and institutions for laboratory use, and wholesale pricing is available through the Modern Aminos wholesale program.
US orders placed before 4 PM CT, Monday through Friday, ship the same business day via FedEx or UPS. Store TAK-653 as supplied, tightly sealed and protected from light, heat, and moisture.
Yes. TAK-653 is sold strictly for in-vitro laboratory research. It is not for human or veterinary use, is not a drug, food, or cosmetic, and is not approved by the FDA for any use.
For research use only. Not for human or veterinary use. TAK-653 is not a drug, food, cosmetic, or dietary product and is not approved by the FDA for any use. It is sold exclusively to qualified researchers and institutions for in-vitro laboratory research. By purchasing, you confirm you will handle it only in a controlled laboratory setting in compliance with all applicable laws.
DISCLAIMER: All compounds and research materials provided by Modern Aminos are strictly for laboratory and research use only. They are not approved for human consumption by the Food and Drug Administration (FDA). No products are approved for oral, sublingual, nor in vivo use. These products should not be used for any form of in vivo experimentation or for any other non-laboratory purpose. Any violation or indication of human or animal use will result in immediate removal from being able to purchase products in the future. By purchasing these products, you acknowledge that they will be used exclusively within a controlled and qualified research environment.
