Seltorexant (JNJ-42847922 / MIN-202) is a high-affinity, non-peptide selective orexin-2 receptor antagonist (2-SORA) engineered for neurochemical, sleep architecture, and mood neurocircuitry research. Demonstrating >140-fold binding selectivity for the Orexin-2 Receptor (OX2R) over the Orexin-1 Receptor (OX1R), Seltorexant dampens hyperarousal by blocking orexinergic transmission onto histaminergic neurons within the tuberomammillary nucleus (TMN). This receptor-selective mechanism promotes physiological non-REM induction while avoiding the cataplexy-like motor intrusion liabilities associated with dual orexin blockade. Modern Aminos supplies analytical-grade Seltorexant in pre-measured 5MG dry-fill solid capsules (60 units per bottle) strictly for in vitro laboratory research, G-protein coupled receptor binding assays, and central nervous system signaling kinetics.
$77.00
In stock
| Quantity | Discounted Price |
|---|---|
| 4 - 6 | $73.92 |
| 7 - 9 | $72.38 |
| 10 + | $70.84 |
Seltorexant (known chemically as JNJ-42847922 or MIN-202) is a non-peptide selective orexin-2 receptor antagonist (2-SORA). Developed to investigate the specific regulatory role of the hypocretin/orexin neuropeptide system in various disorders, Seltorexant selectively targets the Orexin-2 Receptor (OX2R) while sparing Orexin-1 Receptor (OX1R) signaling pathways.
In central neurocellular and receptor-binding assays, Seltorexant binds the OX2R with nanomolar affinity (Ki ≈ 1–3 nM) in isolated receptor-binding assays, displaying greater than 140-fold functional selectivity over OX1R to precisely modulate monoaminergic signaling networks. By selectively targeting OX2R on isolated histaminergic and serotonergic cellular models, it attenuates downstream excitatory cascades, providing a framework for evaluating chronobiological and oscillatory homeostasis in vitro.
Unlike dual orexin receptor antagonists (DORAs), its selective 2-SORA profile spares OX1R-mediated feedback loops in the locus coeruleus and ventral tegmental area. This selective receptor engagement provides a refined molecular tool to study localized neurochemical over-excitation and neuroendocrine cellular responses under induced environmental challenge..
Batch-verified for high analytical purity and mass accuracy at Modern Aminos, Seltorexant is supplied in pre-measured 5MG dry-fill solid capsules (60 units per bottle). Researchers evaluating GPCR binding kinetics, cellular circadian rhythmicity, and localized neuroendocrine signaling study Seltorexant alongside complementary reference standards available on the site, such as L-THP, Emoxypine Succinate, Bromantane, and Glutathione.
| Compound Name | Seltorexant (JNJ-42847922 / MIN-202) |
|---|---|
| Format / Quantity | 5MG Dry-Fill Solid Capsules (60 Units per Bottle) |
| Biological Target | Central Nervous System / Orexin-2 Receptors (OX2R) & Tuberomammillary Histaminergic Pathways |
| Chemical Classification | Selective Orexin-2 Receptor Antagonist (2-SORA) |
| Synonyms / Alt Names | JNJ-42847922, MIN-202, Seltorexant Free Base |
| CAS Number | 1393814-38-0 |
| Chemical Formula | C22H25FN4O2S |
| Molecular Weight | 428.52 g/mol |
| Receptor Binding Affinity | OX2R (Ki ≈ 1.5 nM); >140-fold selectivity over OX1R |
| Primary Signal Transduction | Competitive antagonism of Gq/11 → PLC → IP3 / intracellular Ca2+ mobilization |
| Physical Appearance | White to Off-White Dry-Fill Crystalline Powder in Capsules |
The biochemical pathways and neurochemical targets of Seltorexant (JNJ-42847922) in laboratory research include:
When evaluating published scientific literature and neurochemical monographs for Seltorexant (JNJ-42847922 / MIN-202):
In neurochemical, sleep architecture, and neuroendocrine research, modulatory compounds differ substantially in their receptor subtype selectivity, neurotransmitter systems, and sedative mechanisms:
| Compound / Reference | Chemical Class & Structure | Primary Receptor Targets | Primary Research Profile |
|---|---|---|---|
| Seltorexant | Selective 2-SORA (Non-Peptide) | OX2R (Ki ≈ 1.5 nM); >140x selectivity over OX1R | Selective histaminergic sleep gating, NREM promotion, and HPA axis hyperarousal modeling |
| L-THP | Tetrahydroprotoberberine Alkaloid | Dopamine D1/D2 antagonist; 5-HT1A agonist | Dopaminergic signaling attenuation, central tranquilizing kinetics, and voltage-gated calcium blockade |
| Emoxypine Succinate | Synthetic 3-Hydroxypyridine Salt | Membrane bilayer stabilization; GABA-BZD modulation | Antioxidant membrane kinetics, free-radical quenching, and anxiolytic neuroprotection |
Yes, Modern Aminos is a highly trusted supplier of analytical research chemicals and neurochemical standards. Every batch of Seltorexant 5MG capsules undergoes strict third-party analytical verification (including HPLC and High-Resolution Mass Spectrometry) to confirm minimum 98%+ active chemical purity, verified molecular weight (428.52 g/mol), exact 5MG unit fill calibration, and the complete absence of heavy metals or synthesis impurities.
Seltorexant (JNJ-42847922 / MIN-202) is a synthetic, non-peptide selective orexin-2 receptor antagonist (2-SORA) with a molecular formula of C22H25FN4O2S. It belongs to the 2-SORA class of compounds engineered to specifically block OX2R while avoiding OX1R engagement.
Seltorexant displays >140-fold binding selectivity for OX2R over OX1R. This allows researchers to isolate the role of the orexin-2 pathway in tuberomammillary histaminergic arousal while leaving OX1R pathways in the locus coeruleus and ventral tegmental area intact, avoiding motor tone disruption and cataplexy.
Histaminergic neurons in the TMN express high concentrations of OX2R. Seltorexant blocks endogenous orexin peptides from depolarizing these neurons, leading to reduced histamine release across the cerebral cortex and promoting physiological non-REM sleep onset.
Modern Aminos supplies analytical-grade Seltorexant in pre-measured dry-fill solid capsules containing 5MG of active compound per capsule, bottled in 60-count configurations to ensure precise unit gravimetric mass control for laboratory benchtop research.
Dual Orexin Receptor Antagonists like Suvorexant block both OX1R and OX2R simultaneously. In contrast, Seltorexant is a selective 2-SORA that only blocks OX2R, avoiding broad inhibition of the reward system and preserving autonomic feedback associated with OX1R.
Modern Aminos utilizes High-Performance Liquid Chromatography (HPLC) to confirm active compound purity exceeding 98% and High-Resolution Mass Spectrometry (HRMS) to verify exact molecular mass (428.52 g/mol) and unit gravimetric fill consistency prior to batch release.
Seltorexant capsule bottles should be maintained tightly sealed in a cool, dry environment (15°C to 25°C) protected from direct sunlight, thermal extremes, and atmospheric moisture to preserve solid-phase chemical stability throughout the designated shelf life.
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