Emoxypine Succinate (Mexidol) is a synthetic 3-hydroxypyridine derivative engineered for advanced neuroprotective, antihypoxic, and antioxidant laboratory research. By stabilizing neuronal membrane lipids and suppressing lipid peroxidation, Emoxypine Succinate enhances membrane fluidity and modulates GABAergic receptor binding without causing direct sedation or dependence.
$34.99
| Quantity | Discounted Price |
|---|---|
| 3 - 5 | $33.24 |
| 6 - 8 | $32.54 |
| 9 + | $31.49 |
Emoxypine Succinate (known chemically as Mexidol, Mexifin, or 2-ethyl-6-methyl-3-hydroxypyridine succinate) is a synthetic, membrane-protective antioxidant and antihypoxic compound derived from the structural core of pyridoxine (Vitamin B6). Engineered as a succinate salt of 3-hydroxypyridine, Emoxypine Succinate penetrates biological membranes efficiently to neutralize reactive oxygen species (ROS), inhibit lipid peroxidation, and preserve cell membrane fluidity. Unlike classic GABA-A agonists, Emoxypine studdies suggest it is a non-sedating neuroprotective compound that modulates central receptor sensitivity and suppresses neuroinflammation under hypoxic or ischemic stress.
Formulated by Modern Aminos, each bottle contains 30mL of liquid solution packaged in a light-blocking amber glass bottle with a 1mL precision dropper for exact volumetric measurement. Each 1mL unit delivers 100mg/mL of Emoxypine Succinate dissolved in an aqueous glycerin vehicle stabilized with disodium EDTA, potassium sorbate, and purified water. Researchers looking to buy Emoxypine in standardized liquid format benefit from consistent compound stability without the handling variance of raw nootropic powder.
| Compound Name | Emoxypine Succinate |
|---|---|
| Format & Packaging | 30mL Amber Glass Bottle with 1mL Precision Graduated Dropper |
| Solution Composition | Aqueous glycerin solution: Emoxypine Succinate (100mg/mL), Disodium EDTA, Potassium Sorbate, Purified Water |
| Synonyms / Alt Names | Mexidol, Mexifin, 2-ethyl-6-methylpyridin-3-ol succinate, Emoxypine Salt |
| CAS# | 127484-13-8 (Succinate Salt) | 2364-75-2 (Free Base) |
| Chemical Formula | C8H11NO · C4H6O4 (C12H17NO5) |
| Molecular Weight | 255.27 g/mol (Salt) | 137.18 g/mol (Free Base) |
| IUPAC Name | 2-ethyl-6-methylpyridin-3-ol; butanedioic acid |
| InChIKey | YJXZOSXNIXUSLA-UHFFFAOYSA-N |
| SMILES Code | CCC1=C(C=CC(=N1)C)O.C(CC(=O)O)C(=O)O |
The biochemical pathways and cellular targets of Emoxypine Succinate in neuro-chemical research include:
When evaluating research efficacy and published scientific literature for Emoxypine Succinate (Mexidol):
To evaluate chemical structures, antioxidant pathways, and neuroprotective mechanics, researchers compare Emoxypine Succinate against its free base form, endogenous intracellular antioxidants, and neurotrophic signaling peptides available at Modern Aminos:
| Compound / Product | Primary Target & Class | Core Mechanism of Action | Research Profile & Focus |
|---|---|---|---|
| Emoxypine Succinate | Synthetic 3-Hydroxypyridine Succinate Salt | Inhibits lipid peroxidation, modulates GABA receptor binding affinity, and feeds mitochondrial Complex II via succinate | Multi-target neuroprotective compound providing antihypoxic protection, membrane stabilization, and anti-neuroinflammation without sedation |
| Emoxypine (Free Base) | Unbound 3-Hydroxypyridine Base | Scavenges free radicals directly via the hydroxyl group on the pyridine ring | Lacks the succinate co-factor that drives mitochondrial ATP synthesis; exhibits lower water solubility and shorter biological half-life compared to the succinate salt |
| Glutathione | Endogenous Tripeptide Antioxidant (GSH) | Acts as an essential cofactor for glutathione peroxidase (GPx) to neutralize hydrogen peroxide and lipid hydroperoxides | Focuses on systemic cellular redox balance and hepatic detoxification rather than targeted GABAergic receptor modulation or antihypoxic membrane stabilization |
| P21 | Synthetic Ciliary Neurotrophic Factor (CNTF) Mimetic Peptide | Promotes neurogenesis, synaptic plasticity, and dendritic arborization via CNTF/JAK-STAT pathways | Focuses on structural neural repair, neurotrophic factor stimulation, and memory consolidation rather than direct antioxidant lipid protection |
Emoxypine Free Base refers solely to the 3-hydroxypyridine molecule. Emoxypine Succinate is the succinic acid salt of emoxypine. The inclusion of succinate significantly increases aqueous solubility, enhances cell membrane penetration, and provides an intracellular energy substrate that feeds directly into the mitochondrial Krebs cycle under hypoxic conditions.
Emoxypine Succinate does not bind directly to the GABA binding site as a direct agonist. Instead, it alters the lipid environment of neuronal cell membranes, increasing the binding affinity of GABA receptors for endogenous GABA. This positive allosteric modulation produces anxiolytic and stress-dampening signaling without inducing muscle relaxation, motor impairment, or sedation.
Modern Aminos provides Emoxypine Succinate dissolved at a 100mg/mL concentration in a 30mL amber glass bottle with a graduated 1mL precision dropper. The amber glass shields the light-sensitive 3-hydroxypyridine ring from UV degradation, while the aqueous glycerin solution stabilized with disodium EDTA and potassium sorbate ensures consistent, mess-free liquid handling without needing to weigh raw nootropic powder.
By suppressing lipid peroxidation and neutralizing reactive oxygen species, Emoxypine Succinate prevents the activation of nuclear factor kappa B (NF-κB) in microglial cells. This suppresses the downstream release of pro-inflammatory cytokines (such as TNF-α, IL-1β, and IL-6), making it a valuable tool for studying inflammatory neuro-degeneration models.
The 30mL amber glass bottle should be kept tightly sealed in a cool, dry place (15°C to 25°C) away from direct light and heat. Because the product is supplied as a pre-solubilized aqueous glycerin liquid, it does not require an external reconstitution solution or manual dissolving prior to laboratory use.
The products offered by Modern Aminos are intended strictly for laboratory research purposes only and are sold exclusively to qualified professionals, institutions, and entities. These products are not for human consumption, veterinary use, or any other application involving living organisms, including but not limited to diagnostic, therapeutic, or recreational purposes.
By purchasing this product, you confirm that:
Modern Aminos does not claim that this product is approved by the U.S. Food and Drug Administration (FDA) for any purpose. The statements regarding this product have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
The buyer assumes full responsibility for ensuring the safe handling, storage, and use of this product. Modern Aminos is not liable for any damages, direct or indirect, resulting from improper handling, storage, or unauthorized use of this product. Furthermore, Modern Aminos reserves the right to refuse sales to any individual or entity suspected of misusing its products.
If you have questions about the safe and lawful use of this product, consult a qualified professional with expertise in laboratory research. By proceeding with this purchase, you agree to these terms and conditions.
