BPAP (Benzofuranylpropylaminopentane)

Q: How does BPAP differ from conventional monoaminergic stimulants?

Conventional stimulants (like amphetamines) force continuous, non-vesicular release of stored monoamines independent of neuronal firing, leading to transmitter depletion and receptor downregulation. BPAP only enhances release during active neuronal depolarization, preserving physiological signaling patterns.

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Chemical and Molecular Data

What is BPAP (Benzofuranylpropylaminopentane)?

BPAP (known chemically as (-)-1-(benzofuran-2-yl)-2-propylaminopentane or R-BPAP) is a novel synthetic derivative of PPAP (phenylpropylaminopentane) and selegiline (deprenyl). Developed as a highly potent catecholaminergic and serotonergic activity enhancer (CAE/SAE), BPAP represents a distinct class that enhances action-potential-stimulated neurotransmitter release rather than acting as a direct monoamine releasing agent or reuptake inhibitor. By modulating impulse-evoked exocytosis at ultra-low picomolar concentrations (10^-13 M to 10^-12 M), BPAP amplifies physiological signaling across dopaminergic, noradrenergic, and serotonergic neural circuits without depleting intracellular vesicular transmitter pools. Batch-verified for high analytical purity at Modern Aminos, BPAP is supplied in a 100mcg/mL aqueous liquid solution in a 30mL amber glass bottle with a 1mL precision dropper. Laboratories evaluating neuro-restorative signaling, impulse-dependent monoamine dynamics, and anti-apoptotic survival pathways utilize BPAP alongside complementary neuro-energetic reference standards available on the site, such as 9-Me-BC, Bromantane, NSI-189 Phosphate, and Semax.

Chemical and Molecular Data

Compound Name	BPAP (benzofuranylpropylaminopentane)
Quantity / Formats Offered	100mcg/mL Liquid Solution (30ML Amber Glass Bottle with 1mL Dropper)
Synonyms / Alt Names	(-)-BPAP, R-BPAP, Benzofuranylpropylaminopentane, CAE/SAE Activity Enhancer
CAS Number	182150-13-8 (R-Enantiomer) \| 142617-31-2 (Free Base)
Chemical Formula	C₁₇H₂₅NO
Molecular Weight	259.39 g/mol
IUPAC Name	(2R)-1-(1-benzofuran-2-yl)-N-propylpentan-2-amine
InChIKey	YVIQZOCVJFYPJS-LBOIARJSSA-N
SMILES Code	`CCCC(CC1=CC2=CC=CC=C2O1)NCCC`

What are the Mechanisms of Action?

The biochemical pathways and cellular targets of BPAP in laboratory research include:

Impulse-Propagation-Mediated Monoamine Release Enhancement: BPAP selectively binds activity-enhancer receptor complexes on monoaminergic axon terminals. Upon electrical depolarization, BPAP significantly increases the volumetric release of dopamine, norepinephrine, and serotonin (5-HT) per impulse, without uncontrolled, non-vesicular neurotransmitter dumping in resting cells.
Bimodal Picomolar Potency (CAE/SAE Activity): BPAP exhibits a unique bimodal profile. At low picomolar concentrations (10^-13 M to 10^-12 M), it functions as a potent Catecholaminergic and Serotonergic Activity Enhancer (CAE/SAE), displaying several orders of magnitude higher potency than its structural precursor PPAP.
Neuroprotection Against Neurotoxic Insults: In cell culture models exposed to 1-methyl-4-phenylpyridinium (MPP⁺) or 6-hydroxydopamine (6-OHDA), BPAP upregulates brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), preserving neuronal survival and axonal arborization.

What do Preclinical & Academic Studies Show for BPAP?

When evaluating research efficacy and published scientific literature for BPAP:

Catecholaminergic & Serotonergic Enhancer Kinetics (PubMed): Landmark studies cataloged on PubMed (PMID: 10422775) confirm that BPAP enhances impulse-evoked monoamine release in neuronal tissue preparations at concentrations as low as 10^-13 M without displaying significant monoamine oxidase (MAO-A or MAO-B) inhibition.
Neurotrophic Signaling & Apoptosis Prevention (PMC): Comprehensive reviews archived in PMC (PMC2689929) document BPAP’s ability to protect dopaminergic and serotonergic neuronal cell lines against toxin-induced oxidative apoptosis through BDNF upregulation.
Chemical Profiling & Identification (PubChem): Official structural characterization maintained on PubChem verifies the molecular mass (259.39 g/mol), benzofuran ring topology, and HPLC analytical retention profiles of CAS 182150-13-8.

How does BPAP compare to other compounds?

To evaluate monoaminergic release kinetics, neuroprotective pathways, and receptor targets, researchers compare BPAP against alternative reference standards available at Modern Aminos:

Compound / Reference	Chemical Class & Structure	Core Mechanism of Action	Research Focus & Profile
BPAP	Benzofuranylpropylamine Derivative	Enhances impulse-propagation-mediated release of dopamine, norepinephrine, and 5-HT at picomolar levels	Focuses on physiological monoaminergic activity enhancement, neuroprotection against MPP⁺, and BDNF upregulation
9-Me-BC	Methylated β-Carboline Nootropic	Upregulates Tyrosine Hydroxylase (TH) gene expression and stimulates dopaminergic neurite outgrowth	Focuses on dopaminergic neuron structural restoration, tyrosine hydroxylase induction, and respiratory Complex I support
Bromantane	Synthetic Adamantane Actoprotector	Induces Tyrosine Hydroxylase (TH) and AAAD gene transcription while modulating GABAergic neurotransmission	Focuses on non-depleting dopaminergic biosynthesis, actoprotective physical/mental endurance, and non-sedating anxiolysis
NSI-189 Phosphate	Benzylpiperazine Aminopyridine Complex	Stimulates neurogenesis and synaptic arborization in the hippocampal dentate gyrus	Focuses on hippocampal volume expansion, neurogenesis, and structural neuroplasticity rather than direct monoamine release

Frequently Asked Questions (FAQs)

1. Is Modern Aminos a reliable place to buy BPAP?

Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and novel neuro-active reference compounds. Every batch of BPAP undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ chemical purity, exact 100mcg/mL active concentration, and complete absence of heavy metals or synthesis impurities.

2. What is BPAP and what does CAE/SAE stand for?

BPAP is an acronym for benzofuranylpropylaminopentane. CAE/SAE stands for Catecholaminergic and Serotonergic Activity Enhancer. It refers to a class of compounds that amplify impulse-evoked release of catecholamines (dopamine, norepinephrine) and serotonin without causing non-vesicular transmitter outflow.

3. How does BPAP differ from conventional monoaminergic stimulants?

Conventional monoaminergic stimulants force continuous, non-vesicular release of stored monoamines independent of neuronal firing, leading to transmitter depletion and receptor downregulation. BPAP only enhances release during active neuronal depolarization, preserving physiological signaling patterns.

4. What is the mechanism of impulse-propagation-mediated monoamine release?

When an action potential arrives at a presynaptic terminal, calcium influx triggers exocytosis of neurotransmitter vesicles. BPAP acts on activity-enhancer targets to increase the volume of vesicular release per action potential, increasing signal efficiency without elevating baseline resting levels.

5. What available formats does Modern Aminos offer for BPAP research?

Modern Aminos provides BPAP in a 100mcg/mL liquid solution packaged in a 30mL amber glass bottle with a calibrated 1mL precision dropper. This format allows precise volumetric sampling for cell culture media and tissue bath preparations.

6. How does BPAP compare to 9-Me-BC in central nervous system assays?

BPAP acts as a impulse-dependent neurotransmitter release enhancer across dopaminergic, noradrenergic, and serotonergic neurons. 9-Me-BC focuses primarily on upregulating Tyrosine Hydroxylase gene expression to promote dopaminergic neurite outgrowth and cellular dopamine synthesis.

7. How does Modern Aminos verify the chemical purity and concentration of BPAP?

Modern Aminos utilizes High-Performance Liquid Chromatography (HPLC) to verify active chemical purity exceeding 98% and Mass Spectrometry (MS) to confirm exact molecular mass (259.39 g/mol) and active target density prior to batch release.

8. What are the proper storage and stability parameters for BPAP liquid dropper bottles?

Liquid BPAP bottles should be stored tightly sealed in a cool, dry environment (15°C to 25°C) protected from direct sunlight and UV radiation. The amber glass container prevents photochemical degradation and maintains liquid solution stability over extended shelf lives.

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