BPAP (benzofuranylpropylaminopentane / R-BPAP) is a synthetic catecholaminergic and serotonergic activity enhancer (CAE/SAE) engineered for central nervous system, monoamine release kinetics, and neuroprotection research. Operating at ultra-low picomolar concentrations (10-13 M to 10-12 M), BPAP selectively amplifies impulse-propagation-mediated release of dopamine, norepinephrine, and serotonin (5-HT) without triggering non-vesicular transmitter depletion.
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BPAP (known chemically as (-)-1-(benzofuran-2-yl)-2-propylaminopentane or R-BPAP) is a novel synthetic derivative of PPAP (phenylpropylaminopentane) and selegiline (deprenyl). Developed as a highly potent catecholaminergic and serotonergic activity enhancer (CAE/SAE), BPAP represents a distinct class that enhances action-potential-stimulated neurotransmitter release rather than acting as a direct monoamine releasing agent or reuptake inhibitor.
By modulating impulse-evoked exocytosis at ultra-low picomolar concentrations (10-13 M to 10-12 M), BPAP amplifies physiological signaling across dopaminergic, noradrenergic, and serotonergic neural circuits without depleting intracellular vesicular transmitter pools.
Batch-verified for high analytical purity at Modern Aminos, BPAP is supplied in a 100mcg/mL aqueous liquid solution in a 30mL amber glass bottle with a 1mL precision dropper. Laboratories evaluating neuro-restorative signaling, impulse-dependent monoamine dynamics, and anti-apoptotic survival pathways utilize BPAP alongside complementary neuro-energetic reference standards available on the site, such as 9-Me-BC, Bromantane, NSI-189 Phosphate, and Semax.
| Compound Name | BPAP (benzofuranylpropylaminopentane) |
|---|---|
| Quantity / Formats Offered | 100mcg/mL Liquid Solution (30ML Amber Glass Bottle with 1mL Dropper) |
| Synonyms / Alt Names | (-)-BPAP, R-BPAP, Benzofuranylpropylaminopentane, CAE/SAE Activity Enhancer |
| CAS Number | 182150-13-8 (R-Enantiomer) | 142617-31-2 (Free Base) |
| Chemical Formula | C17H25NO |
| Molecular Weight | 259.39 g/mol |
| IUPAC Name | (2R)-1-(1-benzofuran-2-yl)-N-propylpentan-2-amine |
| InChIKey | YVIQZOCVJFYPJS-LBOIARJSSA-N |
| SMILES Code | CCCC(CC1=CC2=CC=CC=C2O1)NCCC |
The biochemical pathways and cellular targets of BPAP in laboratory research include:
When evaluating research efficacy and published scientific literature for BPAP:
To evaluate monoaminergic release kinetics, neuroprotective pathways, and receptor targets, researchers compare BPAP against alternative reference standards available at Modern Aminos:
| Compound / Reference | Chemical Class & Structure | Core Mechanism of Action | Research Focus & Profile |
|---|---|---|---|
| BPAP | Benzofuranylpropylamine Derivative | Enhances impulse-propagation-mediated release of dopamine, norepinephrine, and 5-HT at picomolar levels | Focuses on physiological monoaminergic activity enhancement, neuroprotection against MPP+, and BDNF upregulation |
| 9-Me-BC | Methylated β-Carboline Nootropic | Upregulates Tyrosine Hydroxylase (TH) gene expression and stimulates dopaminergic neurite outgrowth | Focuses on dopaminergic neuron structural restoration, tyrosine hydroxylase induction, and respiratory Complex I support |
| Bromantane | Synthetic Adamantane Actoprotector | Induces Tyrosine Hydroxylase (TH) and AAAD gene transcription while modulating GABAergic neurotransmission | Focuses on non-depleting dopaminergic biosynthesis, actoprotective physical/mental endurance, and non-sedating anxiolysis |
| NSI-189 Phosphate | Benzylpiperazine Aminopyridine Complex | Stimulates neurogenesis and synaptic arborization in the hippocampal dentate gyrus | Focuses on hippocampal volume expansion, neurogenesis, and structural neuroplasticity rather than direct monoamine release |
Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and novel neuro-active reference compounds. Every batch of BPAP undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ chemical purity, exact 100mcg/mL active concentration, and complete absence of heavy metals or synthesis impurities.
BPAP is an acronym for benzofuranylpropylaminopentane. CAE/SAE stands for Catecholaminergic and Serotonergic Activity Enhancer. It refers to a class of compounds that amplify impulse-evoked release of catecholamines (dopamine, norepinephrine) and serotonin without causing non-vesicular transmitter outflow.
Conventional monoaminergic stimulants force continuous, non-vesicular release of stored monoamines independent of neuronal firing, leading to transmitter depletion and receptor downregulation. BPAP only enhances release during active neuronal depolarization, preserving physiological signaling patterns.
When an action potential arrives at a presynaptic terminal, calcium influx triggers exocytosis of neurotransmitter vesicles. BPAP acts on activity-enhancer targets to increase the volume of vesicular release per action potential, increasing signal efficiency without elevating baseline resting levels.
Modern Aminos provides BPAP in a 100mcg/mL liquid solution packaged in a 30mL amber glass bottle with a calibrated 1mL precision dropper. This format allows precise volumetric sampling for cell culture media and tissue bath preparations.
BPAP acts as a impulse-dependent neurotransmitter release enhancer across dopaminergic, noradrenergic, and serotonergic neurons. 9-Me-BC focuses primarily on upregulating Tyrosine Hydroxylase gene expression to promote dopaminergic neurite outgrowth and cellular dopamine synthesis.
Modern Aminos utilizes High-Performance Liquid Chromatography (HPLC) to verify active chemical purity exceeding 98% and Mass Spectrometry (MS) to confirm exact molecular mass (259.39 g/mol) and active target density prior to batch release.
Liquid BPAP bottles should be stored tightly sealed in a cool, dry environment (15°C to 25°C) protected from direct sunlight and UV radiation. The amber glass container prevents photochemical degradation and maintains liquid solution stability over extended shelf lives.
Disclaimer: All compounds and research materials provided by Modern Aminos are strictly for laboratory and research professional use only. They are not approved for human or animal use nor consumption by the Food and Drug Administration (FDA). These products should not be used for any form of in vivo experimentation or for any other non-laboratory purpose. Any violation or indication of human or animal use will result in immediate removal from being able to purchase products in the future. By purchasing these products, you acknowledge that they will be used exclusively within a controlled and qualified research environment.
The products offered by Modern Aminos are intended strictly for laboratory research purposes only and are sold exclusively to qualified professionals, institutions, and entities. These products are not for human consumption, veterinary use, or any other application involving living organisms, including but not limited to diagnostic, therapeutic, or recreational purposes.
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