Potent NNMT inhibitor for lab research. Targets NAD+ elevation and metabolic reprogramming via selective enzyme inhibition. ≥99% HPLC purity.
Price range: $54.00 through $142.00
| Quantity | Discounted Price |
|---|---|
| 3 - 5 | $51.30 |
| 6 - 8 | $50.22 |
| 9 + | $48.60 |
Purity: ≥99% (HPLC) | Molecular Formula: C₁₀H₁₁N₂⁺ | CAS Number: 1190315-88-7
5-Amino-1MQ is a synthetic methylquinolinium derivative that functions as a highly selective, membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT). In cellular environments, NNMT catalyzes the methylation of nicotinamide to 1-methylnicotinamide (1-MNA). By inhibiting this enzyme, 5-Amino-1MQ prevents the cellular depletion of S-adenosylmethionine (SAM) and facilitates an acute intracellular accumulation of nicotinamide adenine dinucleotide (NAD+). This targeted biochemical shift alters the cellular methylation balance, promoting an upregulation in energy expenditure and fat oxidation pathways in experimental tissue models.
Note: There are no human clinical trials evaluating 5-Amino-1MQ. All current pharmacological data is derived exclusively from in vitro assays and in vivo animal models.
In Caco-2 cell bidirectional permeability assays, 5-Amino-1MQ demonstrated high passive and active membrane transport with no detectable efflux.[1] When applied to cultured 3T3-L1 adipocytes, the compound successfully suppressed lipogenesis and reduced intracellular 1-MNA levels without inducing cytotoxicity at tested concentrations up to 100 µM.[1]
In experimental protocols utilizing diet-induced obese (DIO) mice fed a high-fat diet, systemic administration of 5-Amino-1MQ resulted in significant reductions in overall body weight, white adipose tissue mass, and individual adipocyte size. Notably, these physiological shifts occurred without altering the subjects’ total food intake, isolating the compound’s peripheral metabolic effects.
Recent investigations into aged (24-month-old) murine models examined the compound’s impact on musculoskeletal physiology. The data indicated that NNMT inhibition elevated muscle stem cell proliferation and fusion, resulting in a nearly 2-fold greater cross-sectional area. When combined with exercise protocols, 5-Amino-1MQ administration additively enhanced grip strength, increased daily running distance, and elevated peak tibialis anterior torque by approximately 70% compared to untreated controls.
Analytical LC-MS/MS studies conducted on rat plasma established the basic pharmacokinetic profile of 5-Amino-1MQ. Following administration, the compound displayed a mean terminal elimination half-life of 3.8 hours via intravenous routes and 6.9 hours via oral routes, demonstrating an oral bioavailability (F%) of 38.4% in the murine models.
Modern Aminos’ 5-Amino-1MQ is available in the following preparations:
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The products offered by Modern Aminos are intended strictly for laboratory research purposes only and are sold exclusively to qualified professionals, institutions, and entities. These products are not for human consumption, veterinary use, or any other application involving living organisms, including but not limited to diagnostic, therapeutic, or recreational purposes.
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