Modern Aminos’ Fladrafinil 50mg/ml liquid is third-party tested for purity to guarantee authenticity and potency.
SOLD FOR RESEARCH PURPOSES ONLY
Price range: $44.00 through $89.00
| Quantity | Discounted Price |
|---|---|
| 3 - 5 | $42.24 |
| 7 - 10 | $41.36 |
| 9 + | $40.48 |
Fladrafinil (known chemically as Fluorafinil, CRL-40,941, or 2-{[bis(4-fluorophenyl)methyl]sulfinyl}-N-hydroxyacetamide) is …a novel fluorinated derivative of adrafinil belonging to the benzhydrylsulfinyl chemical class. Originally synthesized as a receptor-binding probe to investigate the modulation of monoaminergic and histaminergic signaling pathways, Fladrafinil features two electron-withdrawing fluorine atoms attached to the para-positions of its bis-phenyl ring system.
This specific halogenation enhances binding affinity for the dopamine transporter (DAT) while resisting rapid hepatic metabolic degradation, allowing researchers to evaluate sustained monoaminergic and α1-adrenergic receptor tone at reduced molar concentrations compared to non-fluorinated precursors.
Batch-verified for high analytical purity at Modern Aminos, Fladrafinil is offered in two standardized laboratory formats:
Laboratories evaluating monoamine reuptake kinetics, cortical electroencephalographic arousal, and central neuro-energetics evaluate Fladrafinil alongside complementary neuro-active reference standards available on the site, such as Bromantane, 9-Me-BC, NSI-189 Phosphate, and BPAP.
| Compound Name | Fladrafinil (Fluorafinil / CRL-40,941) |
|---|---|
| Quantity / Formats Offered | 100mg Dry-Fill Capsules (60 Count) | 50mg/mL Liquid Dropper (30ML Amber Bottle) |
| Synonyms / Alt Names | Fluorafinil, CRL-40,941, Bisfluoromodafinil precursor, CRL 40941 |
| CAS Number | 90212-80-9 |
| Chemical Formula | C15H13F2NO3S |
| Molecular Weight | 325.33 g/mol |
| IUPAC Name | 2-{[bis(4-fluorophenyl)methyl]sulfinyl}-N-hydroxyacetamide |
| InChIKey | WJVDFPFCGXXZKG-UHFFFAOYSA-N |
| SMILES Code | O=S(CC(=O)NO)C(C1=CC=C(F)C=C1)C2=CC=C(F)C=C2 |
The biochemical pathways and cellular targets:
When evaluating research efficacy and published scientific literature:
To evaluate central vigilance mechanisms, monoaminergic targets, and structural profiles, researchers compare Fladrafinil against alternative reference compounds available at Modern Aminos:
| Compound / Reference | Chemical Class & Structure | Core Mechanism of Action | Research Focus & Profile |
|---|---|---|---|
| Fladrafinil (CRL-40,941) | Fluorinated Bis-Phenyl Sulfinylacetamide Eugeroic | Inhibits presynaptic DAT dopamine reuptake and upregulates postsynaptic α1-adrenergic/histaminergic central tone | Focuses on sustained excitatory neural signaling, fluorinated DAT binding kinetics, extended metabolic half-life, and eugeroic arousal |
| Bromantane | Synthetic Adamantane Actoprotector | Upregulates Tyrosine Hydroxylase (TH) gene transcription to increase endogenous dopamine synthesis while modulating GABA | Focuses on sustained dopaminergic biosynthesis, cellular resilience under metabolic stress, and the attenuation of stress-response signaling without inducing baseline neurochemical depression. |
| 9-Me-BC | Methylated β-Carboline Nootropic | Drives Tyrosine Hydroxylase (TH) gene induction, dopaminergic neurite outgrowth, and electron transport Complex I activation | Focuses on structural dopaminergic neuron restoration, neurite arborization, and mitochondrial respiratory support |
| NSI-189 Phosphate | Benzylpiperazine Aminopyridine Derivative | Stimulates neurogenesis and synaptic expansion specifically within the hippocampal dentate gyrus subgranular zone | Focuses on hippocampal structural volume expansion, neurogenesis, and synaptogenesis rather than acute eugeroic arousal |
Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and novel central nervous system reference standards. Every batch of CRL-40,941 undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ chemical purity, correct molecular mass (325.33 g/mol), exact active concentration, and complete absence of heavy metals or synthesis impurities.
CRL-40,941 is a synthetic bis(4-fluorophenyl)methylsulfinylacetamide. It is classified chemically as a fluorinated eugeroic agent designed to modulate central dopamine transporter (DAT) activity and networks of sustained excitatory neural signaling.
CRL-40,941 contains two fluorine atoms positioned on the para-positions of its benzene rings. This fluorination increases lipophilicity, enhances binding affinity for the dopamine transporter, and delays metabolic degradation relative to un-fluorinated adrafinil.
CRL-40,941 acts as a competitive inhibitor of the presynaptic dopamine transporter (DAT). By occupying the DAT binding site, it blocks the reuptake of extracellular dopamine back into the presynaptic neuron, elevating synaptic dopamine concentrations in cortical and striatal cell models.
Modern Aminos provides CRL-40,941 in two standardized laboratory formats: pre-measured 100mg dry-fill solid oral capsules (60 units per bottle) and a 50mg/mL pre-mixed liquid solution packaged in a 30mL amber glass bottle with a calibrated 1mL precision dropper.
CRL-40,941 operates primarily as a presynaptic DAT reuptake inhibitor to prolong dopamine clearance times. Bromantane acts as an actoprotector that upregulates Tyrosine Hydroxylase (TH) gene transcription to increase actual de novo dopamine synthesis while modulating GABAergic pathways.
Modern Aminos utilizes High-Performance Liquid Chromatography (HPLC) to confirm active chemical purity exceeding 98% and Mass Spectrometry (MS) to verify exact molecular weight (325.33 g/mol) and structural identity prior to batch release.
Capsule bottles and liquid dropper containers should be stored tightly sealed in a cool, dry environment (15°C to 25°C) protected from direct sunlight and elevated humidity. Stored under controlled room temperature, CRL-40,941 maintains complete chemical stability throughout its designated shelf life.
Disclaimer: All compounds and research materials provided by Modern Aminos are strictly for laboratory and research professional use only. They are not approved for human or animal use nor consumption by the Food and Drug Administration (FDA). These products should not be used for any form of in vivo experimentation or for any other non-laboratory purpose. Any violation or indication of human or animal use will result in immediate removal from being able to purchase products in the future. By purchasing these products, you acknowledge that they will be used exclusively within a controlled and qualified research environment.
The products offered by Modern Aminos are intended strictly for laboratory research purposes only and are sold exclusively to qualified professionals, institutions, and entities. These products are not for human consumption, veterinary use, or any other application involving living organisms, including but not limited to diagnostic, therapeutic, or recreational purposes.
By purchasing this product, you confirm that:
Modern Aminos does not claim that this product is approved by the U.S. Food and Drug Administration (FDA) for any purpose. The statements regarding this product have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
The buyer assumes full responsibility for ensuring the safe handling, storage, and use of this product. Modern Aminos is not liable for any damages, direct or indirect, resulting from improper handling, storage, or unauthorized use of this product. Furthermore, Modern Aminos reserves the right to refuse sales to any individual or entity suspected of misusing its products.
If you have questions about the safe and lawful use of this product, consult a qualified professional with expertise in laboratory research. By proceeding with this purchase, you agree to these terms and conditions.
