SLU-PP-915 is a 2nd generation pan-agonist of Estrogen-Related Receptors (ERRα, ERRβ, and ERRγ) designed to overcome the limitations of the first-pass metabolism experienced with earlier pan-ERR agonists. Engineered as an advanced compound that mimics the biological adaptations of acute aerobic exertion, SLU-PP-915 activates PGC-1α transcriptional coactivation, promotes mitochondrial oxidative phosphorylation (OXPHOS), and increases Transcription Factor EB (TFEB) autophagic gene expression in myocyte and cardiac cell lines.
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SLU-PP-915 is a novel, synthetic small-molecule pan-agonist targeting orphaned Estrogen-Related Receptors (ERRα, ERRβ, and ERRγ). Developed by researchers at Saint Louis University, SLU-PP-915 represents an advanced second-generation chemical tool designed to overcome the first-pass metabolism limitations of earlier pan-ERR agonists. By binding the ligand-binding domain across all three orphan nuclear receptor subtypes with balanced nanomolar affinity (EC50 ≈ 400 nM), a robust transcriptional program triggers that mimics the biological adaptations of acute aerobic exertion.
Batch-verified for high analytical purity at Modern Aminos, SLU-PP-915 is supplied as a high-purity dry-fill reference material for laboratory screening and cellular assays. Researchers studying mitochondrial biogenesis, oxidative phosphorylation (OXPHOS), and cardiac or metabolic tissue energetics utilize SLU-PP-915 alongside related metabolic modulators on the site, such as SLU-PP-332, GW-501516, SR-9009, and BAM15.
| Compound Name | SLU-PP-915 |
|---|---|
| Quantity / Formats Offered | High-Purity, Dry-Fill Capsules |
| Synonyms / Alt Names | SLU PP 915, Pan-ERR Agonist 915, Orally Active ERR Agonist |
| CAS Number | 2285432-92-8 |
| Chemical Formula | C17H13BFNO3S |
| Molecular Weight | 341.16 g/mol |
| Primary Target Class | Pan-ERR Nuclear Receptor Agonist (ERRα / ERRβ / ERRγ) |
| Receptor Potency (EC50) | ERRα: 414 nM | ERRβ: 435 nM | ERRγ: 378 nM |
| InChIKey | Protected Boron-Containing Small Molecule |
| SMILES Code | Protected Synthetic Structure |
The biochemical pathways and cellular targets in laboratory research include:
When evaluating research efficacy and published scientific literature:
To evaluate nuclear receptor selectivity, pharmacokinetic profiles, and exercise-mimetic pathways, researchers compare SLU-PP-915 against alternative metabolic reference compounds available at Modern Aminos:
| Compound / Reference | Primary Target Class | Core Mechanism of Action | Research Focus & Profile |
|---|---|---|---|
| SLU-PP-915 | Pan-ERR Agonist (Orally Bioavailable) | Binds ERRα, ERRβ, and ERRγ (EC50 ≈ 400 nM) to drive OXPHOS, TFEB autophagic pathways, and exercise mimetics | Second-generation pan-ERR agonist engineered for high survival of the first-pass metabolism, systemic exposure, and chronic metabolic/cardiac research |
| SLU-PP-332 | First-Generation Pan-ERR Agonist | Potent ERRα/β/γ agonism (EC50 = 98 nM for ERRα) driving type IIa oxidative muscle fiber switching | Pioneer pan-ERR research tool with high in vitro potency, primarily evaluated via parenteral or direct cell culture administration |
| GW-501516 (Cardarine) | PPARδ Selective Agonist | Recruits PGC-1α to upregulate skeletal muscle fatty acid beta-oxidation and PDK4 expression | Focuses exclusively on PPARδ nuclear receptor pathways without direct interaction with Estrogen-Related Receptors |
| SR-9009 (Stenabolic) | Rev-Erbα / Rev-Erbβ Agonist | Modulates circadian metabolic gene expression and enhances basal mitochondrial density | Focuses on Rev-Erb nuclear receptors and circadian metabolic control rather than ERR-driven exercise-mimetic pathways |
Yes, Modern Aminos is a trusted vendor for high-purity research chemicals and novel metabolic reference standards. Every batch of SLU-PP-915 undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ purity, correct molecular mass (341.16 g/mol), and complete absence of unreacted synthetic precursors or heavy metals.
SLU-PP-915 is a synthetic boron-containing small molecule that functions as a pan-agonist for Estrogen-Related Receptors (ERRs). It activates all three ERR isoforms—ERRα, ERRβ, and ERRγ—with half-maximal effective concentrations (EC50) around 378–435 nM.
While SLU-PP-332 was the pioneer pan-ERR agonist, its chemical structure limited its oral bioavailability in systemic models. SLU-PP-915 is a chemically distinct second-generation analog optimized to survive the first-pass metabolism and demonstrates favorable pk, enabling expanded systemic and chronic research protocols.
Estrogen-Related Receptors regulate the gene network normally activated during acute aerobic exertion. It stimulates ERR transcriptional targets (such as Ddit4 and Pdk4) in resting muscle cell models, inducing aerobic metabolic adaptations without requiring physical muscle contraction.
SLU-PP-915 increases expression of Transcription Factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy. By upregulating genes like Lamp1, Lamp2, and p62, it supports cellular recycling and mitochondrial quality control under metabolic stress.
GW-501516 is a selective agonist of the PPARδ nuclear receptor. SLU-PP-915 targets an entirely distinct nuclear receptor family—the Estrogen-Related Receptors (ERRα/β/γ). Both upregulate oxidative metabolic responses while operating through separate transcriptional coactivator complexes.
Solid reference samples should be kept tightly sealed in their original containers at -20°C for long-term preservation. Protect from moisture, heat, and direct light exposure to maintain complete chemical stability throughout its laboratory shelf life.
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