Chonluten is a synthetic short peptide bioregulator engineered to investigate epigenetic gene regulation and epithelial homeostasis in pulmonary and broncho-alveolar cell cultures. By binding specific nucleosome domains within bronchial epithelial and alveolar cell lines, Chonluten modulates transcription pathways controlling mucociliary architecture, surfactant synthesis, and pro-inflammatory cytokine suppression (TNF-α, IL-6, IL-8).
Original price was: $54.00.$37.80Current price is: $37.80.
In stock
| Quantity | Discounted Price |
|---|---|
| 4 - 6 | $36.29 |
| 7 - 9 | $35.53 |
| 10 + | $34.78 |
Chonluten (known chemically as L-glutamyl-L-aspartyl-glycine or EDG tripeptide) is a short synthetic peptide bioregulator developed within the Khavinson peptide framework. In the standard Khavinson catalog, Taxorest is the calf-derived bronchial extract known as Cytomax, while Chonluten serves as the branded synthetic counterpart also know as Cytogen. Comprising three active amino acid residues (Glu-Asp-Gly), Chonluten represents a targeted organotropic peptide engineered to modulate transcriptional activity in pulmonary, tracheal, and bronchial epithelial tissues.
Due to its low molecular weight (319.27 g/mol), the Chonluten bioregulator passively diffuses across plasma and nuclear membranes to interact directly with the major and minor grooves of genomic DNA and histone octamers. In bronchial epithelial and pulmonary fibroblast cell lines, this epigenetic binding stimulates the synthesis of structural proteins, normalizes mucociliary cellular differentiation, and downregulates pro-inflammatory signaling cascades triggered by oxidative or xenobiotic stress.
Batch-verified for high analytical purity at Modern Aminos, Chonluten is offered as a 20MG lyophilized dry solid in a 2R glass vial. Researchers studying epigenetic gene modulation, pulmonary tissue resilience, and mucosal barrier dynamics evaluate Chonluten alongside complementary peptide bioregulators available on the site, such as Bronchogen, Cartalax, Vesugen and Pinealon.
| Compound Name | Chonluten (EDG Tripeptide Bioregulator) |
|---|---|
| Format / Quantity | 20MG Lyophilized Dry Powder in 2R Glass Vial |
| Biological Target | Pulmonary & Broncho-Alveolar Epithelial Tissue |
| Chemical Classification | Synthetic Short Peptide Bioregulator (Khavinson Peptide) |
| Peptide Sequence | Glu-Asp-Gly (L-α-glutamyl-L-aspartyl-glycine) |
| Synonyms / Alt Names | EDG, H-Glu-Asp-Gly-OH, Bronchial Bioregulator Peptide |
| CAS Number | 1042385-98-3 |
| Chemical Formula | C11H17N3O8 |
| Molecular Weight | 319.27 g/mol |
| IUPAC Name | (2S)-2-[[(2S)-2-amino-5-hydroxy-5-oxopentanoyl]amino]-3-[(2-hydroxy-2-oxoethyl)amino]-3-oxopropanoic acid |
| InChIKey | InChIKey=KCXQZJRWGFZOHB-UHFFFAOYSA-N |
| SMILES Code | C(CC(=O)O)[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)O)N |
The biochemical pathways and cellular targets of Chonluten in laboratory research include:
When evaluating published scientific literature and bioenergetic monographs for Chonluten (Glu-Asp-Gly):
To evaluate organotropism, peptide length, and biological targets, researchers compare Chonluten against alternative short peptide bioregulators available at Modern Aminos:
| Bioregulator | Peptide Sequence & Length | Biological Target | Primary Research Focus |
|---|---|---|---|
| Chonluten | Glu-Asp-Gly (Tripeptide) |
Pulmonary & Bronchial Epithelium | Mucociliary differentiation, pulmonary structural modulation, and bronchial cytokine suppression |
| Bronchogen | Ala-Glu-Asp-Leu (Tetrapeptide) |
Broncho-Alveolar Tree | Tetrapeptide DNA binding, pulmonary structural matrix modulation and localized respiratory epithelial cell proliferation |
| Cartalax | Ala-Glu-Asp (Tripeptide) |
Articular Cartilage & Chondrocytes | Chondrocyte DNA regulation, type II collagen expression, and joint extracellular matrix protection |
| Vesugen | Lys-Glu-Asp (Tripeptide) |
Vascular Endothelium & Vessel Walls | Endothelial gene regulation, microvascular elasticity, and vascular wall homeostasis |
Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and reference peptide bioregulators. Every batch undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ chemical purity, exact Glu-Asp-Gly sequence stoichiometry, correct molecular weight (319.27 g/mol), and complete absence of heavy metals or synthesis impurities.
Chonluten is a synthetic short peptide bioregulator composed of the three-amino-acid sequence Glu-Asp-Gly (L-glutamyl-L-aspartyl-glycine / EDG). It is designed to evaluate epigenetic modulation in pulmonary and bronchial tissues.
Chonluten crosses cellular and nuclear membranes to bind complementary DNA and histone sites. This interaction relaxes chromatin structure, allowing transcriptional machinery to upregulate structural and protective protein synthesis in bronchial epithelial cells.
Modern Aminos supplies analytical-grade Chonluten as a 20MG lyophilized dry solid in a sterile 2R glass vial, ensuring solid-state stability and precise gravimetric mass control for benchtop research assays.
In pulmonary cell cultures, Chonluten normalizes mucociliary differentiation, supports surfactant protein synthesis, and suppresses excessive pro-inflammatory cytokines (TNF-α, IL-6, IL-8) induced by oxidative or environmental stress.
Literature suggests that while both bioregulators demonstrate similarities in pulmonary assays, each has a greater, and complimentary, affinity to some cascades than others. Chonluten primarily targets oxidative stress, immunomodulatory signaling, and pro-inflammatory cytokine suppression in pulmonary cultures. Bronchogen demonstrates a greater affinity for structural epithelial remodeling and differentiation in pulmonary assays.
Modern Aminos utilizes High-Performance Liquid Chromatography (HPLC) to confirm active chemical purity exceeding 99% and Mass Spectrometry (MS) to verify exact molecular weight (319.27 g/mol) and tripeptide sequence identity prior to batch release.
Lyophilized Chonluten glass vials should be stored tightly sealed in a cool, dry environment (15°C to 25°C) or refrigerated for long-term preservation. Protect from direct light, heat exposure, and atmospheric moisture to maintain solid-state peptide stability.
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