Phenibut HCL is a synthetic phenylated analogue of the primary inhibitory neurotransmitter GABA. Engineered with a lipophilic phenyl ring to facilitate passive diffusion across the blood-brain barrier, Phenibut HCL acts as a full agonist at metabotropic GABAB receptors and functions as an antagonist at α2δ subunit-containing voltage-gated calcium channels (VGCCs). Modern Aminos supplies analytical-grade Phenibut HCL in pre-measured 300mg dry-fill units (60 units per bottle) strictly for in vitro laboratory research, GABAergic receptor kinetics, and neurochemical signaling assays.
$48.00
In stock
| Quantity | Discounted Price |
|---|---|
| 4 - 6 | $46.08 |
| 7 - 9 | $45.12 |
| 10 + | $44.16 |
Phenibut HCL (known chemically as 4-amino-3-phenylbutanoic acid hydrochloride, β-phenyl-γ-aminobutyric acid HCl, or Fenibut) is a synthetic derivative of the primary inhibitory neurotransmitter gamma-aminobutyric acid (GABA). By introducing a phenyl ring at the β-position of the GABA backbone, the molecule achieves high lipophilicity, enabling passive diffusion across lipid membranes and the blood-brain barrier.
Operating across central nervous system signaling pathways, Phenibut HCL functions as a dual-mechanism neurochemical probe. It acts as an agonist at metabotropic GABAB receptors while concurrently binding with high affinity to the α2δ auxiliary subunits of high-voltage-activated calcium channels (a classic gabapentinoid mechanism). At lower experimental concentrations, Phenibut HCL also modulates central dopaminergic transmission and phenethylamine pathways, providing a comprehensive model for investigating inhibitory tone, anxiolytic kinetics, and neuroprotection under excitotoxic stress.
Batch-verified for high analytical purity at Modern Aminos, Phenibut HCL is supplied in pre-measured 300mg dry-fill units (60 units per bottle). Researchers evaluating central inhibitory pathways, calcium channel blockade, and monoaminergic kinetics study Phenibut HCL alongside complementary neurochemical reference standards available on the site, such as L-THP, Bromantane, Nooglutyl, 9-Me-BC, and NSI-189 Phosphate.
| Compound Name | Phenibut HCL (4-Amino-3-Phenylbutanoic Acid Hydrochloride) |
|---|---|
| Format / Quantity | 300mg Dry-Fill Units (60 Units per Bottle) |
| Biological Target | Central Nervous System / GABAB Receptors & α2δ Subunit VGCCs |
| Chemical Classification | Phenylated γ-Aminobutyric Acid Derivative (Hydrochloride Salt) |
| Synonyms / Alt Names | Phenibut Hydrochloride, Fenibut, PhenylGABA, β-Phenyl-GABA HCl |
| CAS Number | 3251-14-7 (HCl Salt) | 1078-21-3 (Free Base) |
| Chemical Formula | C10H13NO2 • HCl (C10H14ClNO2) |
| Molecular Weight | 215.68 g/mol (HCl Salt) | 179.22 g/mol (Free Base) |
| IUPAC Name | (3S)-4-amino-3-phenylbutanoic acid; hydrochloride |
| InChIKey | InChIKey=MTNMCYYCPDCGOB-SBSPUUFOSA-N |
| SMILES Code | C1=CC=C(C=C1)[C@H](CC(=O)O)CN.[Cl] |
The biochemical pathways and cellular targets of Phenibut HCL in laboratory research include:
When evaluating published scientific literature and neuropharmacological monographs for Phenibut HCL:
To evaluate receptor binding selectivity, salt kinetics, and mechanism direction, researchers compare Phenibut HCL against alternative reference compounds available at Modern Aminos:
| Compound / Reference | Chemical Structure & Class | Primary Mechanistic Target | Primary Research Focus |
|---|---|---|---|
| Phenibut HCL | Phenylated GABA (Hydrochloride Salt) | GABAB receptor agonist; α2δ subunit VGCC blocker | Inhibitory neurotransmission, voltage-gated calcium current reduction, and tranquilizing kinetics |
| Phenibut FAA | Phenylated GABA (Free Amino Acid Base) | GABAB receptor agonist; α2δ subunit VGCC blocker | High active base mass assays, neutral pH testing, and alternative vehicle dissolution research |
| L-THP | Tetrahydroprotoberberine Alkaloid | Dopamine D1/D2 antagonist; 5-HT1A agonist; GABA facilitator | Dopaminergic signaling dampening, sedative pathway kinetics, and calcium channel modulation |
| Bromantane | Synthetic Adamantane Actoprotector | Upregulates Tyrosine Hydroxylase to stimulate dopamine synthesis | Dopaminergic upregulation, non-depleting endurance, actoprotective physical energy, and anxiolysis |
Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and reference compounds. Every batch undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify chemical purity, correct molecular weight (215.68 g/mol), and precise 300mg unit mass filling. Additional testing verification – such as heavy metals, residual solvents, and synthesis impurities – will be implemented on this product soon.
Phenibut HCL (4-amino-3-phenylbutanoic acid hydrochloride) is a synthetic phenylated analogue of gamma-aminobutyric acid (GABA). It is classified chemically as a GABA derivative and gabapentinoid calcium channel ligand.
Phenibut HCL acts as an agonist at metabotropic GABAB receptors (opening GIRK potassium channels to hyperpolarize neurons) and competitively blocks α2δ subunits of voltage-gated calcium channels to suppress presynaptic glutamate release.
Modern Aminos supplies analytical-grade Phenibut HCL in pre-measured 300mg dry-fill units packaged in a 60-unit bottle, providing exact gravimetric unit control for laboratory research.
Phenibut HCL is a crystalline hydrochloride salt (~83% active base by weight) offering high aqueous solubility. Phenibut FAA is the free amino acid form (~99.5% active base by weight) with a near-neutral pH in solution but lower water solubility.
Phenibut HCL targets GABAB receptors and α2δ calcium channels. L-THP acts primarily as a dopamine D1/D2 receptor antagonist. Bromantane functions as an actoprotector that upregulates Tyrosine Hydroxylase to stimulate dopamine synthesis.
Modern Aminos utilizes High-Performance Liquid Chromatography (HPLC) to confirm active chemical purity exceeding 98% and Mass Spectrometry (MS) to verify exact molecular weight (215.68 g/mol) and active compound mass prior to batch release.
Phenibut HCL dry-fill units should be stored tightly sealed in a cool, dry environment (15°C to 25°C) protected from direct sunlight, light exposure, and atmospheric moisture to maintain solid-state chemical stability throughout its designated shelf life.
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