Nooglutyl (N-(5-hydroxynicotinoyl)-L-glutamic acid) is a potent synthetic nootropic and neuroprotective agent derived from glutamic acid and 5-hydroxynicotinic acid. Engineered to modulate central glutamatergic signaling, Nooglutyl acts as a positive modulator of AMPA and NMDA receptor complexes, enhancing hippocampal synaptic plasticity, long-term potentiation (LTP), and anti-hypoxic cellular resilience.
$38.00
In stock
| Quantity | Discounted Price |
|---|---|
| 3 - 5 | $36.48 |
| 7 - 10 | $35.72 |
| 9 + | $34.96 |
Nooglutyl (known chemically as N-(5-hydroxynicotinoyl)-L-glutamic acid or ONK-10) is a novel synthetic nootropic compound developed through the structural conjugation of L-glutamic acid with 5-hydroxynicotinic acid. Designed to target central nervous system excitatory pathways, Nooglutyl represents an advanced acyl-glutamate derivative capable of modulating glutamatergic receptor activity without inducing excitotoxic overstimulation.
By enhancing post-synaptic responsiveness across AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) and NMDA (N-methyl-D-aspartate) receptor complexes, Nooglutyl facilitates hippocampal Long-Term Potentiation (LTP). Additionally, its 5-hydroxynicotinoyl moiety provides intrinsic antioxidant activity, neutralizing reactive oxygen species (ROS) and protecting neural cell cultures against hypoxic and ischemic injury.
Batch-verified for high analytical purity at Modern Aminos, Nooglutyl is offered in a pre-measured 10mg dry-fill solid oral capsule format (60 units per bottle). Researchers evaluating memory consolidation, glutamatergic neurotransmission, and anti-hypoxic cellular defense utilize Nooglutyl alongside complementary neuro-active reference standards available on the site, such as Bromantane, 9-Me-BC, NSI-189 Phosphate, and Semax.
| Compound Name | Nooglutyl (ONK-10) |
|---|---|
| Quantity / Formats Offered | 10mg Dry-Fill Capsules (60 Units per Bottle) |
| Chemical Structure | N-Acyl Glutamic Acid Derivative |
| Synonyms / Alt Names | N-(5-hydroxynicotinoyl)-L-glutamic acid, ONK-10, Nooglutil |
| CAS Number | 112193-35-8 |
| Chemical Formula | C11H12N2O6 |
| Molecular Weight | 268.22 g/mol |
| IUPAC Name | (2S)-2-[(5-hydroxypyridine-3-carbonyl)amino]pentanedioic acid |
| InChIKey | Protected Small Molecule Structure |
| SMILES Code | C1=C(C=NC=C1O)C(=O)NC(CCC(=O)O)C(=O)O |
The biochemical pathways and cellular targets include:
When evaluating research efficacy and published scientific literature:
To evaluate central glutamatergic signaling, neuroprotective pathways, and memory consolidation, researchers compare Nooglutyl against alternative reference standards available at Modern Aminos:
| Compound / Reference | Chemical Structure & Class | Core Mechanism of Action | Research Focus & Profile |
|---|---|---|---|
| Nooglutyl | N-(5-hydroxynicotinoyl)-L-glutamic acid | Positively modulates AMPA/NMDA receptors, facilitates LTP, and provides anti-hypoxic cell protection | Focuses on glutamatergic synaptic plasticity, memory consolidation, hippocampal LTP, and ischemic neuroprotection |
| Bromantane | Synthetic Adamantane Actoprotector | Upregulates Tyrosine Hydroxylase (TH) gene expression to increase de novo dopamine synthesis while modulating GABA | Focuses on non-depleting dopaminergic biosynthesis, actoprotective physical endurance, and non-sedating anxiolysis |
| 9-Me-BC | Methylated β-Carboline Derivative | Induces Tyrosine Hydroxylase expression, drives dopaminergic neurite outgrowth, and supports Complex I | Focuses on structural dopaminergic neuron restoration, neurite arborization, and mitochondrial respiratory support |
| NSI-189 Phosphate | Benzylpiperazine Aminopyridine Complex | Stimulates neurogenesis and synaptic expansion specifically in the hippocampal dentate gyrus subgranular zone | Focuses on structural hippocampal volume recovery, dendritic arborization, and neural progenitor cell proliferation |
Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and reference nootropics. Every batch undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ chemical purity, correct molecular weight (268.22 g/mol), exact amide structure fidelity, and complete absence of heavy metals or synthesis impurities.
Nooglutyl (N-(5-hydroxynicotinoyl)-L-glutamic acid) is a synthetic nootropic derivative combining glutamic acid with 5-hydroxynicotinic acid. It is classified as an acyl-glutamate derivative and glutamatergic receptor modulator.
Nooglutyl acts as a positive modulator of AMPA and NMDA glutamatergic receptors. It enhances post-synaptic responsiveness to endogenous glutamate, driving calcium influx and signaling cascades necessary for Long-Term Potentiation (LTP) in hippocampal cell cultures.
In oxygen-deprived cell models, Nooglutyl prevents mitochondrial membrane depolarization, preserves intracellular ATP pools, and quenches hydroxyl free radicals via its 5-hydroxynicotinoyl moiety, halting lipid peroxidation.
Modern Aminos provides Nooglutyl in pre-measured 10mg dry-fill solid oral capsules packaged in a 60 unit bottle to ensure solid-state stability and precise unit-mass control during benchtop weighing and assay dosing.
Nooglutyl focuses on central glutamatergic AMPA/NMDA receptor modulation, hippocampal LTP facilitation, and anti-hypoxic neuroprotection. Bromantane functions as an actoprotector that upregulates Tyrosine Hydroxylase gene transcription to increase dopaminergic biosynthesis while modulating GABA.
Modern Aminos utilizes High-Performance Liquid Chromatography (HPLC) to confirm active chemical purity exceeding 98% and Mass Spectrometry (MS) to verify exact molecular weight (268.22 g/mol) and structural identity prior to batch release.
Nooglutyl capsule bottles should be stored tightly sealed in a cool, dry environment (15°C to 25°C) protected from direct sunlight, light exposure, and heat. Under controlled room temperature conditions, Nooglutyl maintains complete chemical stability throughout its designated shelf life.
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