DADA (Diisopropylamine Dichloroacetate / Diisopropylammonium Dichloroacetate) is a synthetic metabolic regulator and Pyruvate Dehydrogenase Kinase (PDK) inhibitor engineered for cellular energetics and oxidative metabolism research. By inhibiting PDK enzymes, DADA maintains the Pyruvate Dehydrogenase (PDH) complex in its active, unphosphorylated state, promoting glucose oxidation over anaerobic lactate formation while supporting microvascular perfusion.
Price range: $36.75 through $55.50
| Quantity | Discounted Price |
|---|---|
| 3 - 5 | $34.91 |
| 6 - 8 | $34.18 |
| 9 + | $33.08 |
DADA (known chemically as Diisopropylamine Dichloroacetate, Diisopropylammonium Dichloroacetate, or DIPA-DCA) is an equimolar salt formulation combining diisopropylamine with dichloroacetic acid. Functioning as an inhibitor of Pyruvate Dehydrogenase Kinase (PDK), DADA prevents PDK-mediated phosphorylation and inactivation of the Pyruvate Dehydrogenase (PDH) multienzyme complex inside the mitochondrial matrix.
Batch-verified for high analytical purity at Modern Aminos, DADA is supplied in three standardized laboratory formats:
Laboratories investigating mitochondrial respiratory kinetics, lactate clearance, and microvascular hemodynamics utilize DADA alongside complementary metabolic reference standards available on the site, such as SLU-PP-332, BAM15, AICAR, and MOTS-C.
| Compound Name | DADA (Diisopropylamine Dichloroacetate) |
|---|---|
| Quantity / Formats Offered | 20ML Aqueous Vial | 250MG Dry-Fill Capsules (60 Units) | 300MG/ML Liquid Dropper (30ML) |
| Synonyms / Alt Names | Diisopropylammonium dichloroacetate, DIPA-DCA, DADA, Pangamic Acid Active Derivative |
| CAS Number | 660-27-5 |
| Chemical Formula | C8H17Cl2NO2 (C6H15N · C2H2Cl2O2) |
| Molecular Weight | 230.13 g/mol |
| IUPAC Name | N-propan-2-ylpropan-2-amine; 2,2-dichloroacetic acid |
| InChIKey | FWJVIOLMHOXAMJ-UHFFFAOYSA-N |
| SMILES Code | CC(C)[NH2+]C(C)C.C(C(=O)[O-])(Cl)Cl |
The biochemical pathways and cellular targets of DADA in laboratory research include:
When evaluating research efficacy and published scientific literature for DADA (Diisopropylamine Dichloroacetate):
To evaluate metabolic pathways, mitochondrial targets, and cellular respiration mechanics, researchers compare DADA against alternative metabolic reference compounds available at Modern Aminos:
| Compound / Reference | Primary Target Class | Core Mechanism of Action | Research Focus & Profile |
|---|---|---|---|
| DADA (Diisopropylamine Dichloroacetate) | Pyruvate Dehydrogenase Kinase (PDK) Inhibitor / Vasodilator Salt | Inhibits PDK to maintain PDH complex activation, driving mitochondrial pyruvate oxidation over lactate formation | Focuses on glucose oxidation, lactate suppression, mitochondrial respiration, and microvascular perfusion assays |
| SLU-PP-332 | Pan-ERR Nuclear Receptor Agonist | Binds ERRα/β/γ to recruit PGC-1α and upregulate mitochondrial OXPHOS gene networks | Focuses on nuclear receptor-driven mitochondrial biogenesis, exercise mimetics, and oxidative muscle fiber switching |
| BAM15 | Mitochondrial Protonophore Uncoupler | Depolarizes the inner mitochondrial membrane to uncouple oxidative phosphorylation from ATP synthesis | Focuses on nutrient burning, resting metabolic rate elevation, and lipid oxidation without depolarizing plasma membranes |
| AICAR | AMPK Metabolic Master Agonist | Mimics AMP to directly activate AMP-activated protein kinase (AMPK) independent of cellular ATP levels | Focuses on master metabolic switch activation, glucose uptake, and mitochondrial biogenesis signaling |
Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and metabolic reference compounds. Every batch of DADA undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ purity, correct molecular weight (230.13 g/mol), and complete absence of unreacted synthesis precursors or heavy metals.
DADA targets Pyruvate Dehydrogenase Kinase (PDK) enzymes within the mitochondrial matrix. By inhibiting PDK, DADA prevents the inhibitory phosphorylation of Pyruvate Dehydrogenase, maintaining the enzyme in its active state to convert glycolytic pyruvate into acetyl-CoA.
Inhibiting PDK forces cells to channel pyruvate into the Krebs cycle for aerobic oxidative phosphorylation rather than reducing pyruvate to lactate via lactate dehydrogenase (LDH). This increases oxygen consumption and significantly lowers extracellular lactate accumulation.
Diisopropylamine serves as a lipotropic cationic counter-ion that enhances salt stability and cell membrane penetration. In tissue preparations, diisopropylamine exhibits microvascular vasodilatory properties that complement the metabolic actions of dichloroacetate.
Modern Aminos supplies DADA in three standardized laboratory formats: a 20ML aqueous solution in an amber vial, 250MG dry-fill solid oral capsules (60 units per bottle), and a 300MG/ML liquid solution in a 30ML amber glass bottle with a 1mL precision dropper.
BAM15 is a mitochondrial protonophore that uncouples oxidative phosphorylation, while SLU-PP-332 is a nuclear receptor agonist that upregulates metabolic gene transcription. DADA acts directly as an enzyme inhibitor (PDK) to restore pyruvate flux through the Pyruvate Dehydrogenase complex.
Modern Aminos utilizes High-Performance Liquid Chromatography (HPLC) to confirm active purity exceeding 99% and Mass Spectrometry (MS) to verify exact molecular weight (230.13 g/mol) and salt stoichiometry prior to batch release.
Capsule containers, aqueous vials, and liquid dropper bottles should be kept tightly sealed in a cool, dry environment (15°C to 25°C) away from direct light, heat, and atmospheric moisture to maintain solid-state and pre-mixed stability.
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The products offered by Modern Aminos are intended strictly for laboratory research purposes only and are sold exclusively to qualified professionals, institutions, and entities. These products are not for human consumption, veterinary use, or any other application involving living organisms, including but not limited to diagnostic, therapeutic, or recreational purposes.
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