Melatonin Based Amino Blend (20ML) for research. GABA, L-theanine, taurine, histidine, magnesium & melatonin for circadian and inhibitory pathway studies.
$54.00
In stock
| Quantity | Discounted Price |
|---|---|
| 3 - 5 | $51.30 |
| 6 - 8 | $50.22 |
| 9 + | $48.60 |
The Melatonin Based Amino Blend (20ML) is a laboratory-grade, 20ML liquid GABA L-theanine melatonin blend formulated for research into central nervous system inhibitory pathways, glutamatergic excitability, and circadian synchronization. This Melatonin Based Amino Blend combines essential amino acids, inhibitory neuromodulators, and melatonin in a stable matrix for controlled laboratory investigation of sleep-architecture and arousal-network balance in preclinical models.
Research use only. This product is not intended for human consumption. Published human literature cited below refers to individual compounds, not this multi-compound SKU.
Each 20ML vial of this Melatonin Based Amino Blend research reagent contains the following standardized compounds per milliliter:
| Compound | Concentration (per ml) | Research Role |
|---|---|---|
| Gamma-aminobutyric acid (GABA) | 75 mg/ml | Primary CNS inhibitory neurotransmitter standard |
| L-Histidine | 75 mg/ml | Histamine precursor; histaminergic pathway modeling |
| L-Theanine | 50 mg/ml | Glutamatergic signaling modulator |
| Magnesium | 75 mg/ml | NMDA pore blocker; enzymatic cofactor in melatonin synthesis |
| Taurine | 75 mg/ml | Extrasynaptic GABAA receptor activator |
| Melatonin | 200 mcg/ml | MT1/MT2 circadian receptor agonist |
Explore related amino acid research compounds and liquid research formulations from Modern Aminos.
The following summarizes peer-reviewed human literature on individual blend components. It does not establish safety or efficacy of this Melatonin Based Amino Blend (20ML) research product in humans.
External peer-reviewed sources for further analysis:
Preclinical models demonstrated that combining L-Theanine and GABA produced superior modulatory effects compared to single-compound administration. This synergy is driven by the transcriptional up-regulation of GABAA receptors and the GluN1 subunit of the NMDA receptor complex, which restores a balanced inhibitory/excitatory response to glutamatergic signaling (PMC6366437).
Taurine acts as a potent activator of extrasynaptic GABAA receptors in the ventrobasal thalamus, specifically targeting the α4β2δ subtype. This activation elicits a persistent, tonic inhibitory current. Functionally, this action closes the thalamic sensory gate, filtering environmental stimuli and facilitating slow-wave oscillations (PMC6671153).
L-Histidine serves as the essential precursor for histamine synthesis within the tuberomammillary nucleus (TMN) of the hypothalamus. Histaminergic neurons are active during high vigilance and silent during NREM and REM sleep. By supporting this system, L-Histidine helps model the circadian boundary between daytime alertness and nocturnal sleep. In a published study, 4.0 g/day for two weeks reduced fatigue and improved working memory (Sasahara et al.).
Magnesium and Melatonin provide multi-level defense against excitotoxicity in investigational models. Magnesium blocks the NMDA receptor pore, limiting calcium influx. Melatonin attenuates glutamate excitation via MT receptor signaling and NMDA modulation. Magnesium also cofactors serotonin N-acetyltransferase, linking melatonin biosynthesis to magnesium status (PMC12535714; PMC5091650).
The gut-brain axis may explain central effects without requiring high BBB penetration. Gut luminal GABA can activate GABAA and GABAB receptors on vagal afferents, projecting to thalamic, hypothalamic, and brainstem sleep-regulating centers. Published dietary and fermented-dairy studies report effects on sleep latency and NREM duration (MDPI Foods 2025; PMC11025592).
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The products offered by Modern Aminos are intended strictly for laboratory research purposes only and are sold exclusively to qualified professionals, institutions, and entities. These products are not for human consumption, veterinary use, or any other application involving living organisms, including but not limited to diagnostic, therapeutic, or recreational purposes.
By purchasing this product, you confirm that:
Modern Aminos does not claim that this product is approved by the U.S. Food and Drug Administration (FDA) for any purpose. The statements regarding this product have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
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If you have questions about the safe and lawful use of this product, consult a qualified professional with expertise in laboratory research. By proceeding with this purchase, you agree to these terms and conditions.
