LIVAGEN 20MG - Modern Aminos - 3rd-Party Tested | 99% Purity

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Bulk Discount Peptides	3 - 5	3% $52.38
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What is Livagen 20MG?

Livagen (H-Lys-Glu-Asp-Ala-OH, also called Lys-Glu-Asp-Ala, KEDA, the KEDA tetrapeptide and the Livagen bioregulator; CAS 433257-50-2) is a synthetic tetrapeptide built from four L-amino acids: L-Lysine, L-Glutamic acid, L-Aspartic acid and L-Alanine. It belongs to the family of short peptide bioregulators, peptides two to seven residues long, and it is listed in PubChem CID 87919683 as C₁₈H₃₁N₅O₉ with a molecular weight of 461.5 g/mol.
Livagen shares its first three residues, Lys-Glu-Asp, with Prostamax and its first two, Lys-Glu, with Vilon. In a 2023 docking survey of 26 short peptides it ranked 11th of 26 at the LAT1 amino acid transporter (ICM-Score −28.83).
Batch-verified at Modern Aminos, Livagen is supplied in one laboratory format:

20 mg lyophilized powder, single sealed glass vial

Modern Aminos is the best place to buy peptides online. We are a trusted Research Chemicals vendor of third-party tested, high-quality research chemicals made in the USA: every USA-made Livagen vial is third-party tested, with guaranteed purity and sterilized vials. Our products are routinely and rigorously tested for purity, and the current certificate is in the Certificate of Analysis tab.
Laboratories building short-peptide comparison panels often place Livagen next to other public reference listings such as Prostamax, Vilon, Pinealon, Bronchogen and Cartalax.

Chemical and Molecular Data for Livagen 20MG

Compound Name	Livagen 20MG (Lys-Glu-Asp-Ala)
Research Category	Short peptide bioregulator; synthetic tetrapeptide; peptide-transporter docking reference compound
Quantity / Formats Offered	20 mg Lyophilized Powder (sealed glass vial)
Peptide Sequence	`H-Lys-Glu-Asp-Ala-OH` (KEDA); all four residues L
Synonyms / Alt Names	Lys-Glu-Asp-Ala, KEDA, K-E-D-A, H-KEDA-OH, H-Lys-Glu-Asp-Ala-OH, L-Lys-L-Glu-L-Asp-L-Ala, Livagen peptide, Livagen bioregulator
CAS Number	433257-50-2
PubChem CID	87919683
Chemical Formula	C₁₈H₃₁N₅O₉
Molecular Weight	461.5 g/mol
Exact Mass	461.2122 Da
Stereochemistry	Four defined stereocenters, all L (S configuration)
Computed Properties (PubChem)	XLogP3 −7.7; hydrogen-bond donors 8; hydrogen-bond acceptors 11; topological polar surface area 251 Å²; rotatable bonds 16; heavy atoms 32
IUPAC Name	(4S)-5-[[(2S)-3-carboxy-1-[[(1S)-1-carboxyethyl]amino]-1-oxopropan-2-yl]amino]-4-[[(2S)-2,6-diaminohexanoyl]amino]-5-oxopentanoic acid
InChI	InChI=1S/C18H31N5O9/c1-9(18(31)32)21-17(30)12(8-14(26)27)23-16(29)11(5-6-13(24)25)22-15(28)10(20)4-2-3-7-19/h9-12H,2-8,19-20H2,1H3,(H,21,30)(H,22,28)(H,23,29)(H,24,25)(H,26,27)(H,31,32)/t9-,10-,11-,12-/m0/s1
InChIKey	IKVDKWACACMDLR-BJDJZHNGSA-N
SMILES Code	`CC(C(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCCCN)N` (connectivity; the all-L (S) configuration is encoded in the InChI and InChIKey)

Identity fields are drawn from PubChem CID 87919683; certificate results are in the Certificate of Analysis tab.

What are the Mechanisms of Action?

The biochemical targets and binding logic of Livagen in laboratory research include:

Predicted binding at the LAT1 amino acid transporter: In a docking survey of 26 ultrashort peptides, KEDA ranked 11th at the LAT1 binding site with an ICM-Score of −28.83 (PDB 6IRT). That score is more favorable than the reference LAT1 ligands L-Leucine (−23.96) and BCH (−17.37) in the same study, and less favorable than the potent inhibitor JPH203 (−31.50) (Khavinson et al., 2023).
The C-terminal residue sets the LAT1 score: Within the same survey, the three Lys-Glu-Asp tetrapeptides differ only in their last residue: KEDG scored −34.05, KEDA −28.83 and KEDP −22.79, while the tripeptide KED alone scored −24.79. A reasonable inference is that the small, flexible Alanine end lets KEDA settle deeper into the LAT1 pocket than the ring-locked Proline end of Prostamax, though the paper does not test that explanation directly.
Weaker predicted binding at PEPT1: At the PEPT1 di- and tri-peptide transporter, KEDA ranked 20th of 26 (−16.70, PDB 7PN1), close to Vilon’s Lys-Glu (−17.02) and well behind Prostamax’s KEDP (−33.42). It still scored more favorably than three of the four reference PEPT1 compounds tested (PMC10046148).
Mixed-charge chemistry: Livagen carries two basic amines (the N-terminal amine and the Lysine side chain) and three carboxylic acids (Glu, Asp and the C-terminus). In DNA melting measurements, short peptides with the same mixed-charge Lys-Glu-Asp pattern, KEDP among them, changed double-helix stability (Solovyev et al., 2015); KEDA was not measured there, so a similar effect is a reasonable inference rather than a result.
C-terminal Alanine chemistry: Unlike Proline, Alanine keeps its backbone N–H, so the Asp-Ala link in Livagen is a secondary amide. That is part of why PubChem counts 8 hydrogen-bond donors for C₁₈H₃₁N₅O₉, one more than Prostamax, along with 16 rotatable bonds and a computed XLogP3 of −7.7.

Peptide	Sequence	Formula and Molecular Weight (PubChem)	LAT1 ICM-Score	PEPT1 ICM-Score
Livagen	Lys-Glu-Asp-Ala (KEDA)	C₁₈H₃₁N₅O₉, 461.5 g/mol	−28.83	−16.70
Prostamax	Lys-Glu-Asp-Pro (KEDP)	C₂₀H₃₃N₅O₉, 487.5 g/mol	−22.79	−33.42
Vilon	Lys-Glu (KE)	C₁₁H₂₁N₃O₅, 275.30 g/mol	−19.02	−17.02
Pinealon	Glu-Asp-Arg (EDR)	C₁₅H₂₆N₆O₈, 418.40 g/mol	−45.32	−37.59
Bronchogen	Ala-Glu-Asp-Leu (AEDL)	C₁₈H₃₀N₄O₉, 446.5 g/mol	−25.11	−25.35
Cartalax	Ala-Glu-Asp (AED)	C₁₂H₁₉N₃O₈, 333.29 g/mol	−28.14	−18.95

Docking scores are from Khavinson et al., 2023; more negative ICM-Scores indicate more favorable predicted binding. Formulas and weights are from PubChem.

What Does Published Research Show for Livagen?

Peer-reviewed literature on Livagen 20MG and its Lys-Glu-Asp-Ala sequence centers on transporter docking and structure verification:

Transporter Docking (PMC): Computer-assisted docking of 26 ultrashort peptides to LAT1, LAT2, PEPT1 and PEPT2 ranked KEDA 11th at LAT1 (−28.83) and 20th at PEPT1 (−16.70) (PMC10046148).
DNA Melting Biophysics (PubMed): Mixed-charge Lys-Glu-Asp peptides such as KEDP changed DNA melting temperature and double-helix stability; KEDA shares that charge pattern but was not part of the measured set (PubMed 25841380).
Chemical Directory & Structure Verification (PubChem): CAS 433257-50-2, C₁₈H₃₁N₅O₉, 461.5 g/mol, exact mass 461.2122 Da, InChIKey IKVDKWACACMDLR-BJDJZHNGSA-N, biologic line notation H-Lys-Glu-Asp-Ala-OH (PubChem 87919683). PubChem also links the structure to patent records US7101854 and EP1325026.
Analytical Quality: Why chromatographic testing matters for reference materials is covered in Modern Aminos’ note on HPLC testing.

How does Livagen compare to other compounds?

To map how sequence and C-terminal structure change transporter binding, researchers compare Livagen against other short peptide reference compounds, including several available at Modern Aminos:

Compound / Reference	Primary Target Class	Core Mechanism of Action	Research Focus & Profile
Livagen 20MG	Tetrapeptide (Lys-Glu-Asp-Ala), C₁₈H₃₁N₅O₉, 461.5 g/mol	11th-ranked LAT1 docking score among 26 short peptides (ICM-Score −28.83)	KED core with a C-terminal Alanine; transporter docking reference
Prostamax	Tetrapeptide (Lys-Glu-Asp-Pro), C₂₀H₃₃N₅O₉, 487.5 g/mol	Same Lys-Glu-Asp core; second-ranked PEPT1 score and weaker LAT1 score than KEDA	One-residue (Ala to Pro) comparator for C-terminal structure-activity work
Vilon	Dipeptide (Lys-Glu), C₁₁H₂₁N₃O₅, 275.30 g/mol	Docking places Lys-Glu along the DNA minor groove; PEPT1 score close to KEDA	Minimal-length reference for the Livagen N-terminus
Pinealon	Tripeptide (Glu-Asp-Arg), C₁₅H₂₆N₆O₈, 418.40 g/mol	Top LAT1 and PEPT1 docking scores in the same survey	DNA and histone binding biophysics reference
Bronchogen	Tetrapeptide (Ala-Glu-Asp-Leu), C₁₈H₃₀N₄O₉, 446.5 g/mol	Glu-Asp core shared with Livagen; ranked 6th at PEPT1 and 20th at LAT1	Tetrapeptide comparator with a hydrophobic C-terminus

Frequently Asked Questions (FAQs)

1. Is Modern Aminos a reliable place to buy Livagen (Lys-Glu-Asp-Ala)?

Yes. Modern Aminos is the best place to buy peptides online and a trusted Research Chemicals vendor, offering guaranteed purity and sterilized vials. Modern Aminos publishes a third-party certificate from Freedom Diagnostics Testing for Livagen, and all applicable tests are performed on our products. If you want to buy Lys-Glu-Asp-Ala as a documented reference material, the certificate is in the Certificate of Analysis tab.

2. What is Livagen?

Livagen is a synthetic tetrapeptide with the sequence Lys-Glu-Asp-Ala (KEDA), built from L-Lysine, L-Glutamic acid, L-Aspartic acid and L-Alanine. Modern Aminos supplies it strictly for laboratory research use. PubChem lists it as C18H31N5O9 at 461.5 g/mol under CID 87919683.

3. Is Livagen a peptide or an amino acid?

Livagen is a peptide. Its four amino acids are joined by three peptide bonds, which makes it a tetrapeptide, and it is sold as a single defined sequence rather than a blend of free amino acids.

4. What is Livagen made of?

Livagen is made of four L-amino acids linked in this order from the free amine end: L-Lysine, L-Glutamic acid, L-Aspartic acid and L-Alanine. Modern Aminos supplies it as 20 mg of lyophilized powder in a sealed glass vial.

5. What is the molecular target of Livagen?

Docking work predicted binding at the LAT1 amino acid transporter. In a 2023 survey of 26 ultrashort peptides, Livagen (KEDA) ranked 11th at LAT1 with an ICM-Score of −28.83, more favorable than the reference ligands L-Leucine (−23.96) and BCH (−17.37) (Khavinson et al., 2023).

6. How is Livagen different from Prostamax?

The two tetrapeptides differ by one residue: both start with Lys-Glu-Asp, but Livagen ends in Alanine (KEDA) while Prostamax ends in Proline (KEDP). That one change lowers the formula by C2H2 and the mass by 26 g/mol, and in the 2023 docking survey it gave KEDA the stronger LAT1 score (−28.83 vs −22.79) and KEDP the stronger PEPT1 score (−33.42 vs −16.70).

7. How does Livagen relate to Vilon?

Vilon is the dipeptide Lys-Glu, which forms the first two residues of Livagen. Livagen extends that pair with Aspartic acid and Alanine, and the two scored almost the same at PEPT1 in the 2023 docking survey (−16.70 for KEDA, −17.02 for KE).

8. What is the CAS number and PubChem CID for Livagen?

Livagen is listed under CAS 433257-50-2 and PubChem CID 87919683. PubChem records the formula as C18H31N5O9 with a molecular weight of 461.5 g/mol and InChIKey IKVDKWACACMDLR-BJDJZHNGSA-N.

9. What available formats does Modern Aminos offer for Livagen research?

Modern Aminos offers one format: 20 mg of lyophilized powder in a sealed glass vial. A capsule or liquid format is not offered for this listing.

10. How does Livagen compare to Pinealon and Bronchogen in docking studies?

In the same 2023 survey, Pinealon (Glu-Asp-Arg) scored best of all 26 peptides at both LAT1 and PEPT1, Livagen ranked 11th at LAT1 and 20th at PEPT1, and Bronchogen (Ala-Glu-Asp-Leu) ranked 20th at LAT1 and 6th at PEPT1 (Khavinson et al., 2023). For a plain-language walk through the sequence, see What Is Livagen? The Lys-Glu-Asp-Ala (KEDA) Tetrapeptide Explained.

11. How is Livagen tested?

All applicable tests are performed on our products. Certificates of analysis can be looked up on our COA Search page. The current third-party Freedom Diagnostics Testing certificate is published in the Certificate of Analysis tab, and upcoming batches receive expanded testing across two ISO-certified labs, covering Sterility, Identity, Purity, Endotoxin, Heavy Metals, Mass, Residual Solvents, Fentanyl and Conformity. The identity fields on this page (CAS, InChI, InChIKey, SMILES) come from PubChem CID 87919683.

12. What are the proper storage protocols for Livagen vials?

Keep the sealed glass vial cool, dry and away from direct light, and limit how often it is opened so the lyophilized powder stays free of moisture. Follow the label on each lot.