VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide belonging to the secretin/glucagon superfamily. Operating as a primary signal in neuroscience and endocrine research, VIP selectively agonizes Gs-coupled VPAC1 and VPAC2 receptors, activating the adenylate cyclase/cAMP/PKA pathway. VIP modulates nuclear factor kappa B (NF-κB) nuclear translocation to inhibit pro-inflammatory cytokines (TNF-α, IL-6) while enhancing the synthesis of the anti-inflammatory IL-10.
$60.00
In stock
| Quantity | Discounted Price |
|---|---|
| 4 - 6 | $57.60 |
| 7 - 9 | $56.40 |
| 10 + | $55.20 |
VIP (known chemically as Vasoactive Intestinal Peptide or Vasoactive Intestinal Polypeptide) is a synthetic 28-amino-acid neuropeptide belonging to the secretin/glucagon superfamily. Originally isolated from porcine intestinal tissue, VIP functions as a master transmitter bridging central neuroscience and peripheral endocrine systems. Its primary structure (His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2) features a highly conserved alpha-helical domain essential for high-affinity receptor binding.
Operating through two main G-protein coupled receptor subtypes—VPAC1 and VPAC2—the primary vasoactive intestinal peptide function involves activating adenylate cyclase, elevating cyclic AMP (cAMP) levels, and modulating downstream Protein Kinase A (PKA) phosphorylation. This pathway governs smooth muscle relaxation, mucosal fluid secretion, circadian rhythm synchronization in the suprachiasmatic nucleus (SCN), and immune cell cytokine suppression.
Batch-verified for high analytical purity at Modern Aminos—recognized by academic laboratories as the premier source to buy vip peptide online—VIP is supplied as a standardized reference material for cell culture and biochemical research. When evaluating VIP nasal spray matrices or pre-solubilized liquid formulations, laboratories study vasoactive intestinal peptide nasal spray delivery vehicles for non-invasive mucosal transport assays across the blood-brain barrier. Investigators evaluate vip peptide pathways alongside complementary immunomodulatory and neuro-regulatory standards available on the site, such as KPV, PEA (Palmitoylethanolamide), and PT-141 (Bremelanotide).
| Compound Name | VIP (Vasoactive Intestinal Peptide) |
|---|---|
| Quantity / Formats Offered | High-Purity Lyophilized Reference Powder Material |
| Peptide Sequence | H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-OH |
| Synonyms / Alt Names | Vasoactive Intestinal Polypeptide, Aviptadil, VIP Peptide, PHM-27 precursor fragment |
| CAS Number | 40077-57-4 |
| Chemical Formula | C147H237N43O43S |
| Molecular Weight | 3326.80 g/mol |
| IUPAC Name | L-histidylethanethioyl-L-seryl-L-α-aspartyl-L-alanyl-L-valyl-L-phenylalanyl-L-threonyl-L-α-aspartyl-L-asparaginyl-L-tyrosyl-L-threonyl-L-arginyl-L-leucyl-L-arginyl-L-lysyl-L-glutaminyl-L-methionyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-asparaginyl-L-seryl-L-isoleucyl-L-leucyl-L-asparaginamide |
| InChIKey | VBUWHHLIZKOSMS-RIWXPGAOSA-N |
| SMILES Code | CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CN=CN4)N |
The biochemical pathways and cellular targets:
When evaluating research efficacy and published scientific literature:
To evaluate receptor pathways, immunomodulatory actions, and neuro-endocrine signaling, researchers compare VIP against alternative reference standards available at Modern Aminos:
In preclinical research, investigators compare delivery vehicle formulations based on experimental targets:
| Compound / Reference | Chemical Structure & Class | Primary Receptor Target | Research Focus & Profile |
|---|---|---|---|
| VIP (Vasoactive Intestinal Peptide) | 28-Amino-Acid Neuropeptide | VPAC1 & VPAC2 [Gs-Coupled] | Focuses on neuro-endocrine modulation, cytokine inhibition (TNF-α/IL-6), circadian SCN synchronization, and Treg cell differentiation |
| KPV | α-MSH C-Terminal Tripeptide (Lys-Pro-Val) | Inhibits NF-κB Nuclear Translocation | Focuses on targeted mucosal barrier anti-inflammation, gut epithelial cell stabilization, and acute cytokine dampening |
| PEA (Palmitoylethanolamide) | Endogenous N-Acylethanolamine Fatty Acid Amide | PPAR-α Agonist & Indirect CB1/CB2/GPR55 Modulator | Focuses on neuro-inflammatory signaling cascades, mast cell degranulation inhibition, and glial activation dampening |
| PT-141 (Bremelanotide) | Synthetic Cyclic Heptapeptide | Melanocortin MC3R & MC4R [Gs-Coupled] | Focuses on central hypothalamic melanocortinergic signaling, adenylate cyclase/cAMP activation, and autonomic neuro-endocrine pathways |
Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and reference peptides. Every batch of VIP peptide undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ chemical purity, exact 28-amino-acid sequence fidelity, correct molecular mass (3325.80 g/mol), and complete absence of heavy metals or synthesis impurities.
VIP (Vasoactive Intestinal Peptide) is a naturally occurring 28-amino-acid neuropeptide that acts as a potent signaling molecule in both the central nervous system and peripheral tissues. It belongs to the secretin/glucagon peptide superfamily and regulates vascular, endocrine, and immune cell responses.
In laboratory research, VIP is used to study G-protein coupled receptor kinetics (VPAC1 and VPAC2), anti-inflammatory signaling pathways, circadian clock gene synchronization in suprachiasmatic neurons, intestinal epithelial ion transport, and smooth muscle vasodilation mechanisms.
In cellular systems, VIP binds VPAC1 and VPAC2 receptors to activate adenylate cyclase, elevating cyclic AMP (cAMP) and Protein Kinase A (PKA) activity. This cascade regulates gene transcription, inhibits NF-κB translocation, promotes cell survival, and regulates electrolyte and fluid secretion across epithelial barriers.
VIP is synthesized by neurons in the central nervous system (specifically the suprachiasmatic nucleus and cerebral cortex) and the peripheral nervous system (myenteric and submucosal plexuses of the gut). It is also produced by specific endocrine cells and activated immune cells, including T-lymphocytes and dendritic cells.
The primary biological effects of VIP include relaxation of vascular and non-vascular smooth muscle (vasodilation and bronchodilation), inhibition of pro-inflammatory cytokine secretion (TNF-α, IL-6, IL-12), stimulation of anti-inflammatory IL-10, maintenance of mucosal barrier integrity, and modulation of hypothalamic circadian rhythms.
In preclinical cellular biology and mucosal research, VIP nasal spray formulations are studied as non-invasive delivery systems to investigate direct olfactory nerve pathway transport across the blood-brain barrier, targeting central VPAC receptors in hypothalamic and hippocampal neural networks without systemic degradation.
VIP modulates immune response systems by binding VPAC1/VPAC2 receptors on macrophages and T-cells, suppressing IκB degradation and blocking NF-κB nuclear translocation. This inhibits pro-inflammatory cytokine transcription (TNF-α, IL-1β, IL-6) while enhancing anti-inflammatory IL-10 synthesis and driving CD4+ T-cell differentiation toward regulatory T-cell (Treg) phenotypes.
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