Pinealon (EDR Tripeptide / Glutamyl-aspartyl-arginine) is a synthetic short-chain peptide bioregulator engineered for central nervous system and neuro-epigenetic research. By interacting directly with chromatin DNA structures, Pinealon regulates neuronal gene expression, suppresses intracellular reactive oxygen species (ROS), and inhibits apoptotic cascades in brain tissue cell lines.
$61.00
In stock
| Quantity | Discounted Price |
|---|---|
| 3 - 5 | $57.95 |
| 6 - 8 | $56.73 |
| 9 + | $54.90 |
Pinealon (known chemically as EDR Tripeptide, Glutamyl-aspartyl-arginine, or L-glutamyl-L-aspartyl-L-arginine) is a synthetic short-chain peptide bioregulator belonging to the Khavinson class of. Composed of three amino acids (Glu-Asp-Arg), the Pinealon Bioregulator was developed to study central nervous system cellular aging, neuro-epigenetic gene regulation, and neuronal cell survival under hypoxia and oxidative stress.
Batch-verified for high analytical purity at Modern Aminos, Pinealon is supplied as a 20MG lyophilized reference powder sealed in a 2R (3mL) borosilicate glass. Because short-chain tripeptides readily penetrate cell membranes and nuclear structures without complex transport machinery, researchers utilize Pinealon in cell culture assays to evaluate chromatin de-condensation, gene transcription restoration, and free radical neutralization alongside related peptide bioregulators and neuro-modulators available on the site, such as Epithalon, Semax, Selank, and Cortexin.
| Compound Name | Pinealon (Pinealon Bioregulator) |
|---|---|
| Quantity / Formats Offered | 20MG Lyophilized Powder in 2R (3ML) borosilicate glass |
| Peptide Sequence | Glu-Asp-Arg (EDR) |
| Synonyms / Alt Names | EDR Tripeptide, Glutamyl-aspartyl-arginine, Pinealon Peptide, Khavinson CNS Bioregulator |
| CAS Number | 1629828-09-5 |
| Chemical Formula | C15H26N6O8 |
| Molecular Weight | 418.40 g/mol |
| IUPAC Name | (2S)-2-[[(2S)-2-[[(2S)-2-amino-4-carboxybutanoyl]amino]-3-carboxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid |
| InChIKey | UJBXNWJVAMYIAG-LBOIARJSSA-N |
| SMILES Code | C(CC(=O)O)C(C(=O)NC(CC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)O)N |
The biochemical pathways and cellular targets:
When evaluating research efficacy and published scientific literature:
To evaluate peptide sequences, cellular targets, and neuroprotective pathways, researchers compare Pinealon against alternative reference standards available at Modern Aminos:
| Compound / Reference | Chemical Class & Structure | Core Mechanism of Action | Research Focus & Profile |
|---|---|---|---|
| Pinealon | Synthetic Tripeptide Bioregulator (Glu-Asp-Arg) | Binds chromatin DNA to regulate neuronal gene transcription, suppress ROS, and inhibit Caspase-3 apoptosis | Focuses on cerebral cortex protection, and gene expression restoration in neuronal models |
| Epithalon | Synthetic Tetrapeptide Bioregulator (Ala-Glu-Asp-Gly) | Induces telomerase enzyme activity and elongation in somatic cell cultures, regulating pineal gland secretion | Focuses on systemic cellular senescence, telomere length dynamics, and pineal gland circadian rhythm research |
| Semax | ACTH(4-10) Derived Heptapeptide Analog | Upregulates hippocampal BDNF and NGF expression while modulating central dopaminergic and cholinergic pathways | Focuses on cognitive activation and consolidation, and acts as an acute neuro-vascular protectant during elevated ischemic events |
| Selank | Tuftsin-Derived Heptapeptide Analog | Stabilizes endogenous enkephalins, increases BDNF expression, and modulates GABAergic neurotransmission | Focuses on central neuropeptide stability, immunomodulation and ischemic buffering models |
Yes, Modern Aminos is a highly trusted vendor for high-purity research peptides and bioregulators. Every batch of Pinealon undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ purity, correct EDR tripeptide sequence identity, and complete absence of unreacted amino acid fragments or heavy metals.
Pinealon is a synthetic tripeptide consisting of three amino acids: L-glutamic acid, L-aspartic acid, and L-arginine (Glu-Asp-Arg / EDR). Its chemical formula is C15H26N6O8 with a molecular weight of 418.40 g/mol.
Due to its short sequence length and small molecular mass, Pinealon penetrates plasma membranes and nuclear envelopes. It binds directly to histone proteins and DNA double-helix grooves, inducing structural chromatin changes that allow RNA polymerase to transcribe previously silenced neuro-protective genes.
In neuronal cell culture assays subjected to hypoxia or ischemic oxidative stress, Pinealon suppresses formation of reactive oxygen species, reduces lipid peroxidation, and upregulates transcription of endogenous antioxidant enzymes such as superoxide dismutase (SOD).
Epithalon is a tetrapeptide (Ala-Glu-Asp-Gly) focused on telomerase activation, telomere elongation, and pineal gland regulation. Pinealon is a tripeptide (Glu-Asp-Arg) specifically targeted to central nervous system tissue, chromatin gene expression, and neuronal ROS protection.
Tripeptides possess a low molecular weight (< 500 Da) and balanced lipophilicity. This allows them to cross plasma membranes and nuclear envelopes via passive diffusion or basic peptide transporters without requiring specialized receptor-mediated endocytosis.
Unopened lyophilized Pinealon vials should be stored frozen at -20°C for long-term preservation. Protect from direct light, heat, and moisture. Once converted into an aqueous solution, store between 2°C and 8°C and use within designated laboratory testing windows.
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