Epithalon (AEDG) is a synthetic tetrapeptide bioregulator engineered to investigate telomerase activation, telomere length dynamics, and epiphyseal neuroendocrine regulation. By interacting directly with nucleosomal DNA and upregulating telomerase reverse transcriptase (TERT) gene transcription, Epithalon stimulates cellular lifespan extension in cultured somatic cells while normalizing circadian pineal signaling.
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| Quantity | Discounted Price |
|---|---|
| 4 - 6 | $38.40 |
| 7 - 9 | $37.60 |
| 10 + | $36.80 |
Epithalon (known chemically as Epitalon, L-alanyl-L-glutamyl-L-aspartyl-glycine, or AEDG tetrapeptide) is a synthetic short peptide bioregulator developed within the Khavinson peptide framework. Comprising four active amino acid residues (Ala-Glu-Asp-Gly), Epithalon was designed to replicate the primary biological activity of epithalamin, an endogenous polypeptide extract isolated from the epiphyseal (pineal) gland.
Operating primarily through epigenetic gene transactivation, Epithalon traverses both cellular and nuclear envelopes due to its low molecular weight (390.35 g/mol). Once in the nucleus, Epithalon interacts with histone octamers and genomic DNA grooves to upregulate telomerase reverse transcriptase (TERT) expression, reactivating telomerase enzyme synthesis to overcome replicative senescence in cultured somatic cells. Concurrently, it stabilizes pinealocyte signaling, regulating circadian transcription rhythms and cellular antioxidant defense mechanisms.
Batch-verified for high analytical purity at Modern Aminos, Epithalon is supplied as a 10MG lyophilized dry solid in a 2R glass vial. Researchers studying cellular senescence, telomeric maintenance, and neuroendocrine signaling evaluate Epithalon alongside complementary peptide bioregulators available on the site, such as Pinealon, Vesugen, Cartalax, and Chonluten.
| Compound Name | Epithalon (AEDG Tetrapeptide Bioregulator) |
|---|---|
| Format / Quantity | 10MG Lyophilized Dry Powder in 2R Glass Vial |
| Biological Target | Epiphyseal (Pineal) Neuroendocrine System & Telomeric Chromatin |
| Chemical Classification | Synthetic Short Peptide Bioregulator (Khavinson Peptide) |
| Peptide Sequence | Ala-Glu-Asp-Gly (L-alanyl-L-α-glutamyl-L-α-aspartyl-glycine) |
| Synonyms / Alt Names | Epitalon, Epithalone, H-Ala-Glu-Asp-Gly-OH, Epithalamin Synthetic Analogue |
| CAS Number | 307297-39-8 |
| Chemical Formula | C14H22N4O9 |
| Molecular Weight | 390.35 g/mol |
| IUPAC Name |
(4S)-4-[[(2S)-2-aminopropanoyl]amino]-5-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
|
| InChIKey | InChIKey=HGHOBRRUMWJWCU-FXQIFTODSA-N |
| SMILES Code | C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)O)N |
The biochemical pathways and cellular targets of Epithalon (AEDG) in laboratory research include:
When evaluating published scientific literature and bioenergetic monographs for Epithalon (Ala-Glu-Asp-Gly):
To evaluate biological targets, peptide length, and tissue specificity, researchers compare Epithalon against alternative short peptide bioregulators available at Modern Aminos:
| Bioregulator / Compound | Peptide Sequence & Length | Biological Target | Primary Research Focus |
|---|---|---|---|
| Epithalon | Ala-Glu-Asp-Gly (Tetrapeptide) |
Epiphyseal Neuroendocrine System & Telomeric DNA | TERT gene activation, telomerase induction, cellular senescence, and pineal rhythm modeling |
| Pinealon | Glu-Asp-Arg (Tripeptide) |
Cerebral & Cortical Neuronal Cells | Neuronal protection, synaptic transmission, cognitive signaling, and cellular antioxidant resilience |
| Vesugen | Lys-Glu-Asp (Tripeptide) |
Vascular Endothelium & Vessel Walls | Endothelial gene regulation, microvascular elasticity, and vascular wall homeostasis |
| Cartalax | Ala-Glu-Asp (Tripeptide) |
Articular Cartilage & Chondrocytes | Chondrocyte DNA regulation, type II collagen expression, and joint extracellular matrix protection |
Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and reference peptide bioregulators. Every batch undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 99%+ chemical purity, exact Ala-Glu-Asp-Gly sequence stoichiometry, correct molecular weight (390.35 g/mol), and complete absence of heavy metals or synthesis impurities.
Epithalon (also known as Epitalon) is a synthetic short peptide bioregulator composed of the four-amino-acid sequence Ala-Glu-Asp-Gly (AEDG). It is engineered to model the activity of epiphyseal gland peptides.
Epithalon binds to the promoter region of the telomerase reverse transcriptase (TERT) gene, stimulating TERT expression and activating catalytic telomerase enzyme synthesis to extend telomere length in somatic cell models.
Modern Aminos supplies analytical-grade Epithalon as a 10MG lyophilized dry solid in a sterile 2R glass vial, ensuring solid-state stability and precise gravimetric mass control for benchtop research assays.
Epithalon normalizes pinealocyte functional activity in vitro, stimulating indolamine pathway enzymes to support circadian melatonin synthesis rhythms and cellular redox resilience.
Epithalon (Ala-Glu-Asp-Gly) is a tetrapeptide focused on TERT activation and pineal chromatin. Pinealon (Glu-Asp-Arg) is a tripeptide targeting cerebral cortical neurons, while Vesugen (Lys-Glu-Asp) targets vascular endothelial tissue.
Modern Aminos utilizes High-Performance Liquid Chromatography (HPLC) to confirm active chemical purity exceeding 99% and Mass Spectrometry (MS) to verify exact molecular weight (390.35 g/mol) and tetrapeptide sequence structure prior to batch release.
Lyophilized Epithalon glass vials should be stored tightly sealed in a cool, dry environment (15°C to 25°C) or refrigerated for long-term preservation. Protect from direct light, heat exposure, and atmospheric moisture to maintain solid-state peptide stability.
Disclaimer: All compounds and research materials provided by Modern Aminos are strictly for laboratory and research professional use only. They are not approved for human or animal use nor consumption by the Food and Drug Administration (FDA). These products should not be used for any form of in vivo experimentation or for any other non-laboratory purpose. Any violation or indication of human or animal use will result in immediate removal from being able to purchase products in the future. By purchasing these products, you acknowledge that they will be used exclusively within a controlled and qualified research environment.
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