Oxytocin is a synthetic mammalian nonapeptide hormone (Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 with a 1-6 disulfide bridge) engineered for neuro-endocrine, smooth muscle contraction, and central neuropeptidergic research. By selectively activating the Gq-coupled Oxytocin Receptor (OXTR), Oxytocin stimulates intracellular calcium mobilization via the Phospholipase C (PLC) pathway.
$29.00
| Quantity | Discounted Price |
|---|---|
| 3 - 5 | $27.84 |
| 7 - 10 | $27.26 |
| 9 + | $26.68 |
Oxytocin is a naturally occurring cyclic nonapeptide neuropeptide synthesized within the paraventricular and supraoptic nuclei of the hypothalamus. Characterized by its conserved nine amino acid sequence (Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2) with a modern intramolecular disulfide bridge between Cysteine-1 and Cysteine-6, Oxytocin serves as a foundational neuro-endocrine signal across mammalian physiology.
Operating primarily through the G-protein coupled Oxytocin Receptor (OXTR), Oxytocin regulates peripheral myoepithelial and vascular smooth muscle tone while modulating central social affiliation, stress attenuation, and reward pathways in limbic brain structures.
Batch-tested for high analytical purity at Modern Aminos, Oxytocin is offered in a standardized laboratory format:
Laboratories investigating neuro-endocrine receptor kinetics, smooth muscle excitation-contraction coupling, and central behavioral signaling evaluate Oxytocin alongside complementary neuropeptide and melanocortinergic reference standards available on the site, such as PT-141 (Bremelanotide), Melanotan II, and Kisspeptin-10.
| Compound Name | Oxytocin (Hypothalamic Nonapeptide) |
|---|---|
| Quantity / Formats Offered | 5MG Lyophilized Powder (2R Glass Vial) | 10MG Lyophilized Powder (2R Glass Vial) |
| Peptide Sequence | Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (Disulfide Bridge: Cys1–Cys6) |
| Synonyms / Alt Names | Alpha-hypophamine, Pitocin, Oxytocic Hormone, OXT |
| CAS Number | 50-56-6 |
| Chemical Formula | C43H66N12O12S2 |
| Molecular Weight | 1007.19 g/mol |
| IUPAC Name | 1-({(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacyclohenicosan-16-yl}carbonyl)-L-prolyl-L-leucylglycinamide |
| InChIKey | XAHKRIXOARWGHG-DMYRUZCASA-N |
| SMILES Code | CCC(C)C1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)O |
The biochemical pathways and cellular targets of Oxytocin in laboratory research include:
When evaluating research efficacy and published scientific literature for Oxytocin:
To evaluate receptor selectivity, signal transduction, and physiological targets, researchers compare Oxytocin against alternative neuropeptide reference standards available at Modern Aminos:
While both compounds are investigated for their roles in central nervous system signaling and autonomic neuro-endocrine responses, Oxytocin and PT-141 (Bremelanotide) operate through entirely distinct molecular receptor families:
| Compound / Reference | Chemical Class & Structure | Primary Receptor Target | Research Focus & Profile |
|---|---|---|---|
| Oxytocin | Cyclic Nonapeptide (1–6 Disulfide Bridge) | Oxytocin Receptor (OXTR) [Gq/11-Coupled] | Focuses on intracellular calcium mobilization, smooth muscle contraction, and central oxytocinergic bonding/stress attenuation |
| PT-141 (Bremelanotide) | Synthetic Cyclic Heptapeptide | Melanocortin MC3R & MC4R [Gs-Coupled] | Focuses on central hypothalamic melanocortinergic signaling, adenylate cyclase/cAMP activation, and autonomic arousal pathways |
| Melanotan II | Synthetic Cyclic Lactam Analogue | Non-selective MC1R, MC3R, MC4R, MC5R | Focuses on melanogenesis, skin pigmentation models, and non-selective central melanocortin receptor activation |
| Kisspeptin-10 | Decapeptide Fragment (Kiss-1) | GPR54 (KISS1R) [Gq/11-Coupled] | Focuses on hypothalamic GnRH pulse generation, pituitary gonadotropin (LH/FSH) release, and HPG axis regulation |
Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and reference peptides. Every batch of Oxytocin undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ purity, correct disulfide bridge geometry, exact peptide sequence identity, and complete absence of heavy metals or synthesis impurities.
Oxytocin is a cyclic nonapeptide with the primary sequence Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2. An intramolecular disulfide bond links the cysteine residues at positions 1 and 6, forming a 6-amino-acid cyclic ring with a 3-amino-acid C-terminal tail.
Oxytocin binds Gq-coupled Oxytocin Receptors (OXTR) to trigger intracellular calcium signaling and smooth muscle modulation. PT-141 is a cyclic peptide that targets Gs-coupled central Melanocortin receptors (MC3R/MC4R), activating adenylate cyclase and cAMP pathways in hypothalamic dopamine centers.
Upon binding OXTR, Oxytocin activates Phospholipase C (PLC), which cleaves PIP2 into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). IP3 triggers rapid calcium release from the endoplasmic reticulum into the cytoplasm.
Modern Aminos supplies Oxytocin in two standardized glass vial formats: a 5MG lyophilized reference powder vial ($29) and a 10MG lyophilized reference powder vial ($36). Both formats feature sealed rubber stoppers to preserve peptide stability.
The disulfide bridge between Cys1 and Cys6 holds the N-terminal ring in the specific rigid conformation required to fit into the ligand-binding pocket of OXTR. Reduction or cleavage of this disulfide bond completely abolishes receptor binding affinity.
Unopened lyophilized Oxytocin vials should be stored frozen at -20°C for long-term preservation. Protect from direct light, heat, and moisture. Once reconstituted into liquid solution, store refrigerated between 2°C and 8°C and use within designated laboratory testing windows.
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