Kisspeptin-10 (metastin 45-54 / YNWNSFGLRF-NH2) is an endogenous 10-amino-acid decapeptide fragment and master activator of the hypothalamic-pituitary-gonadal (HPG) axis. Binding with high nanomolar affinity to Gq/11-coupled KISS1R (GPR54) receptors, Kisspeptin-10 stimulates pulsatile Gonadotropin-Releasing Hormone (GnRH) secretion in arcuate and preoptic hypothalamic neurons, driving downstream Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) release.
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| Quantity | Discounted Price |
|---|---|
| 3 - 5 | $47.04 |
| 7 - 10 | $46.06 |
| 9 + | $45.08 |
Kisspeptin-10 Research Peptide (known chemically as metastin 45-54 or KISS1 112-121 fragment) is the shortest fully functional C-terminal amidated decapeptide fragment of the human KISS1 gene precursor. Comprising 10 amino acids (Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2), Kisspeptin-10 functions as the primary endogenous ligand for the G-protein coupled receptor KISS1R (formerly known as GPR54).
Positioned at the apex of the neuroendocrine hierarchy, Kisspeptin-10 acts as the master upstream regulator of the hypothalamic-pituitary-gonadal (HPG) axis. By binding KISS1R on arcuate and anteroventral periventricular (AVPV) hypothalamic neurons, Kisspeptin-10 triggers synchronized, pulsatile secretion of Gonadotropin-Releasing Hormone (GnRH). This upstream pulse drives the downstream synthesis and pituitary release of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH).
Batch-verified for high analytical purity at Modern Aminos, Kisspeptin-10 Research Peptide is offered as a standardized 10MG lyophilized reference standard in a 2R glass vial. Researchers evaluating neuroendocrine pulse generators, gonadotropin release dynamics, and metastatic tumor suppression utilize Kisspeptin-10 alongside complementary endocrine reference standards available on the site, such as Gonadorelin (GnRH), Triptorelin, Human Chorionic Gonadotropin (hCG), and Oxytocin.
| Compound Name | Kisspeptin-10 (Metastin 45-54) |
|---|---|
| Quantity / Formats Offered | Lyophilized Dry Powder in Sterile Glass Vial |
| Peptide Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 |
| Synonyms / Alt Names | Kisspeptin-10, Kp-10, Metastin (45-54), KISS1 (112-121), YNWNSFGLRF-NH2 |
| CAS Number | 374675-21-5 |
| Chemical Formula | C63H83N17O14 |
| Molecular Weight | 1302.45 g/mol |
| IUPAC Name | L-tyrosyl-L-asparaginyl-L-tryptophyl-L-asparaginyl-L-seryl-L-phenylalanylglycyl-L-leucyl-L-arginyl-L-phenylalaninamide |
| InChIKey | Protected Peptide Sequence Matrix |
| SMILES Code | Protected Peptide Sequence Matrix |
The biochemical pathways and cellular targets of Kisspeptin-10 Research Peptide in laboratory research include:
When evaluating research efficacy and published scientific literature for Kisspeptin-10:
To evaluate neuroendocrine hierarchy, receptor targets, and gonadotropin release mechanics, researchers compare Kisspeptin-10 Research Peptide against alternative reference standards available at Modern Aminos:
In reproductive endocrinology and cellular signaling research, the site of pathway intervention determines how the overall axis responds:
| Compound / Reference | Chemical Class & Structure | Primary Target & Level of Action | Research Focus & Profile |
|---|---|---|---|
| Kisspeptin-10 | C-Terminal Amidated Decapeptide Fragment | Hypothalamic KISS1R (GPR54) Agonist (Upstream Apex) | Drives native hypothalamic GnRH pulses to release endogenous LH and FSH; preserves central HPG feedback mechanisms |
| HCG (Human Chorionic Gonadotropin) | Heterodimeric Glycoprotein Hormone | Gonadal LH/hCG Receptor Agonist (Downstream) | Mimics LH activity directly at Leydig/granulosa cells; stimulates intratesticular steroidogenesis without native FSH release |
| HMG (Human Menopausal Gonadotropin) | Purified Glycoprotein Hormone Mixture | Gonadal LH/hCG & FSH Receptors (Downstream) | Directly supplies 1:1 exogenous LH and FSH activity to stimulate Leydig steroidogenesis and Sertoli germ cell maturation |
| Gonadorelin (GnRH) | Endogenous Decapeptide (GnRH Native Sequence) | Pituitary Gonadotrope GnRH Receptor (Mid-Level) | Acts directly at pituitary receptors to trigger acute LH/FSH release; bypasses hypothalamic kisspeptin control |
Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and reference peptides. Every batch undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ chemical purity, exact decapeptide sequence fidelity, correct molecular weight (1302.45 g/mol), and complete absence of heavy metals or synthesis impurities.
Kisspeptin-10 is the active 10-amino-acid C-terminal fragment of the human KISS1 gene product (metastin 45-54). It contains the essential sequence domain (YNWNSFGLRF-NH2) required for high-affinity receptor binding and biological activity.
Kisspeptin-10 agonizes KISS1R (GPR54) receptors on hypothalamic neurons, stimulating pulsatile release of Gonadotropin-Releasing Hormone (GnRH). Portal GnRH then acts on pituitary gonadotropes to drive Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) secretion.
KISS1R activation recruits Gq/11 proteins, activating Phospholipase C (PLC) to generate IP3 and DAG. This triggers rapid intracellular calcium (Ca2+) release and activates Protein Kinase C (PKC) and ERK1/2 (MAPK) phosphorylation cascades.
Kisspeptin-10 operates upstream at the hypothalamic level to fire native GnRH pulses, forcing the pituitary to secrete endogenous LH and FSH. HCG acts downstream at the gonadal level to mimic LH only. HMG provides exogenous LH and FSH activity directly to the gonads. Unlike HCG and HMG, Kisspeptin-10 preserves central feedback loops.
Originally identified as metastin, Kisspeptin-10 binds KISS1R to inhibit cell motility, chemotaxis, and focal adhesion dynamics in metastatic cell lines, suppressing tumor invasion in experimental metastasis models.
Modern Aminos utilizes High-Performance Liquid Chromatography (HPLC) to confirm active chemical purity exceeding 98% and Mass Spectrometry (MS) to verify exact molecular weight (1302.45 g/mol) and 10-amino-acid decapeptide sequence identity prior to batch release.
Lyophilized Kisspeptin-10 glass vials should be stored tightly sealed in a cool, dry environment (15°C to 25°C) or refrigerated for long-term preservation. Protect from direct heat, light exposure, and atmospheric moisture to maintain solid-state peptide stability.
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