GHK-Cu (Glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring copper-binding signal tripeptide engineered for extracellular matrix (ECM) remodeling, gene expression regulation, and cellular tissue repair research. Targeted delivery of copper(II) ions directly to target cells, GHK-Cu upregulates collagen type I and III synthesis, modulates matrix metalloproteinase (MMP) enzymatic activity, and stimulates endogenous antioxidant gene pathways in cell culture models.
Price range: $42.00 through $109.00
| Quantity | Discounted Price |
|---|---|
| 3 - 5 | $39.90 |
| 6 - 8 | $39.06 |
| 9 + | $37.80 |
GHK-Cu (known chemically as Glycyl-L-histidyl-L-lysine copper complex or Copper Tripeptide-1) is a naturally occurring plasma tripeptide with a high binding affinity for copper(II) ions. Originally identified in human serum, GHK-Cu serves as a vital signal peptide that regulates extracellular matrix (ECM) remodeling, promotes fibroblast proliferation, and resets gene expression toward regenerative and antioxidant pathways.
Batch-verified for high analytical purity at Modern Aminos, GHK-Cu is supplied in two versatile laboratory formats: a 50MG high-density lyophilized reference powder sealed in a 2R (3ML) glass vial and pre-measured 2MG dry-fill solid oral capsules (60 units per bottle). Researchers studying cell-matrix interactions, enzymatic tissue remodeling, and genomic responses utilize GHK-Cu for the remodeling of the extracellular matrix and modulates anti-inflammatory cytokines along with KPV and Glutathione.
| Compound Name | GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper Complex) |
|---|---|
| Quantity / Formats Offered | 50MG Lyophilized Powder (2R Vial) | 2MG Dry-Fill Capsules (60 Units per Bottle) |
| Peptide Sequence | Gly-His-Lys:Cu2+ |
| Synonyms / Alt Names | Copper Tripeptide-1, GHK Copper Complex, Glycyl-Histidylate-Lysine Copper |
| CAS Number | 49557-75-7 |
| Chemical Formula | C14H22CuN6O4 |
| Molecular Weight | 405.90 g/mol |
| IUPAC Name | copper(2+);2-[[2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-6-aminohexanoate |
| InChIKey | JXZAOBWUGMXXS-UHFFFAOYSA-N |
| SMILES Code | C(CCN)CC(C(=O)O)NC(=O)C(CC1=CN=CN1)NC(=O)CN.[Cu+2] |
The biochemical pathways and cellular targets of GHK-Cu in laboratory research include:
When evaluating research efficacy and published scientific literature for GHK-Cu (Copper Tripeptide-1):
To evaluate structural matrix remodeling, anti-inflammatory properties, and cellular pathways, researchers compare GHK-Cu against alternative reference standards available at Modern Aminos:
| Compound / Reference | Chemical Class & Structure | Core Mechanism of Action | Research Focus & Profile |
|---|---|---|---|
| GHK-Cu | Copper-Chelated Signal Tripeptide (Gly-His-Lys:Cu2+) | Upregulates collagen I/III, elastin, and GAG synthesis while modulating MMP/TIMP enzymatic matrix balance | Focuses on extracellular matrix (ECM) remodeling, fibroblast migration, copper transport, and genomic gene expression resetting |
| Pentadecapeptide Arginate (PDA) | Synthetic Gastric Pentadecapeptide Arginate | Activates VEGFR2, promotes focal adhesion kinase (FAK) signaling, and accelerates angiogenesis; bound to Arginate reduces the effects of first-pass metabolic degradation | Focuses on mucosal integrity, and microvascular sprouting through growth factor signaling. |
| KPV | α-MSH C-Terminal Tripeptide (Lys-Pro-Val) | Inhibits nuclear factor kappa B (NF-κB) nuclear translocation to block pro-inflammatory cytokines | Focuses strictly on targeted cellular anti-inflammation, mucosal barrier protection, and acute cytokine dampening |
| Glutathione | Endogenous Tripeptide Antioxidant (GSH) | Acts as a cofactor for glutathione peroxidase (GPx) to neutralize hydrogen peroxide and reactive oxygen species | Focuses on systemic cellular redox balance, heavy metal chelation, and hepatic detoxification pathways |
Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals, peptides, and copper complexes. Every batch of GHK-Cu undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ purity, correct copper chelation stoichiometry, and complete absence of unreacted peptide fragments or heavy metal impurities.
GHK-Cu is a small signal tripeptide (Glycyl-L-histidyl-L-lysine) chelated to a divalent copper ion. The nitrogen atoms on the histidine imidazole ring and glycine amine backbone coordinate with Cu with extremely high binding affinity, forming a stable bioavailable chelate complex.
In fibroblast cell cultures, GHK-Cu upregulates mRNA expression for collagen types I and III, elastin, and decorin. Additionally, it regulates matrix metalloproteinases (MMPs), ensuring balanced degradation of damaged structural proteins alongside newly synthesized matrix assembly.
Genome-wide expression profiling shows that GHK-Cu alters the transcription of over 4,000 human genes. It upregulates DNA repair enzymes and antioxidant pathways—such as Cu/Zn Superoxide Dismutase (SOD1)—while downregulating pro-inflammatory cytokine signaling.
Modern Aminos provides GHK-Cu in two standardized formats: a 50MG high-density lyophilized reference powder in a 2R (3ML) glass vial and pre-measured 2MG dry-fill solid oral capsules (60 units per bottle). Both formats deliver consistent active material purity for in vitro screening protocols.
GHK-Cu is a copper-binding tripeptide that focuses primarily on extracellular matrix remodeling, collagen I/III synthesis, and gene expression resetting. Pentadecapeptide Arginate is a synthetic gastric pentadecapeptide that acts through VEGFR2 activation, focal adhesion kinase (FAK) signaling, and vascular endothelial growth factor pathways.
The GHK tripeptide acts as a specific carrier designed to transport copper ions across biological membranes. Copper is an essential cofactor for enzymes like lysyl oxidase (which cross-links collagen and elastin) and superoxide dismutase (SOD1), making chelation necessary for full biological efficacy.
Lyophilized GHK-Cu vials and capsule containers should be stored tightly sealed in a cool, dry environment (15°C to 25°C) or frozen (-20°C) for long-term preservation. Once transformed into an aqueous solution with a sterile laboratory buffer, an aqueous GHK-Cu solution should be kept refrigerated (2°C to 8°C) and protected from direct light exposure.
The products offered by Modern Aminos are intended strictly for laboratory research purposes only and are sold exclusively to qualified professionals, institutions, and entities. These products are not for human consumption, veterinary use, or any other application involving living organisms, including but not limited to diagnostic, therapeutic, or recreational purposes.
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Modern Aminos does not claim that this product is approved by the U.S. Food and Drug Administration (FDA) for any purpose. The statements regarding this product have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
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If you have questions about the safe and lawful use of this product, consult a qualified professional with expertise in laboratory research. By proceeding with this purchase, you agree to these terms and conditions.
