DSIP (δ-Sleep Inducing Peptide) is a synthetic, naturally occurring amphiphilic nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) engineered for central nervous system, electroencephalographic (EEG) rhythm, and neuro-endocrine research. Operating as a neuromodulator of slow-wave δ-sleep architecture, DSIP normalizes hypothalamic-pituitary-adrenal (HPA) axis stress dynamics by dampening basal ACTH release and mitigating oxidative cellular injury.
$35.00
In stock
| Quantity | Discounted Price |
|---|---|
| 3 - 5 | $33.25 |
| 6 - 8 | $32.55 |
| 9 + | $31.50 |
DSIP (known chemically as δ-Sleep Inducing Peptide, Delta-Sleep Inducing Peptide, or Emideltide) is a naturally occurring, highly conserved nonapeptide isolated from the hemodialysate of sleeping mammals during early slow-wave sleep research. Structurally characterized by its linear nine amino acid sequence (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu), DSIP research indicates it functions as an endogenous neuromodulator capable of crossing plasma membranes and the blood-brain barrier without enzymatic degradation.
Batch-verified for high analytical purity at Modern Aminos, DSIP is supplied as a 5MG lyophilized reference powder sealed in a 2R (3mL) glass vial. Researchers investigating slow-wave electroencephalographic (δ-wave) spindle generation, circadian neuro-endocrine synchronization, and stress-induced glucocorticoid buffering utilize DSIP alongside complementary circadian and neuropeptidergic reference standards available on the site, such as the Melatonin Based Amino Blend (20ML), Epithalon, and Selank.
| Compound Name | DSIP (δ-Sleep Inducing Peptide) |
|---|---|
| Quantity / Formats Offered | 5MG Lyophilized Powder in 2R (3ML) Glass Vial |
| Peptide Sequence | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE) |
| Synonyms / Alt Names | Delta-sleep-inducing peptide, Emideltide, DSIP Nonapeptide |
| CAS Number | 62568-57-4 |
| Chemical Formula | C35H48N10O15 |
| Molecular Weight | 848.81 g/mol |
| IUPAC Name | L-tryptophyl-L-alanylglycylglycyl-L-α-aspartyl-L-alanyl-L-seryl-glycyl-L-glutamic acid |
| InChIKey | NBSPWWKZDMNLMW-UHFFFAOYSA-N |
| SMILES Code | CC(C(=O)NCC(=O)NCC(=O)NC(CC(=O)O)C(=O)NC(C)C(=O)NC(CO)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)O)NC(=O)C(CC1=CNC2=CC=CC=C21)N |
The biochemical pathways and cellular targets:
When evaluating research efficacy and published scientific literature:
To evaluate neuropeptide targets, slow-wave EEG induction, and circadian pathways, researchers compare DSIP against alternative reference formulations available at Modern Aminos:
| Compound / Reference | Chemical Class & Structure | Core Mechanism of Action | Research Focus & Profile |
|---|---|---|---|
| DSIP (δ-Sleep Inducing Peptide) | Synthetic Amphiphilic Nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) | Potentiates thalamic slow-wave δ-wave (0.5–4 Hz) EEG spindles and suppresses stress-induced HPA axis ACTH release | Focuses on slow-wave sleep architecture, neuro-endocrine HPA axis stabilization, and central anti-stress/antioxidant defense |
| Melatonin Based Amino Blend (20ML) | Aqueous Indoleamine & Amino Acid Liquid Complex | Agonizes suprachiasmatic nucleus MT1/MT2 receptors to regulate circadian phase shifts and dark-cycle signaling | Focuses on immediate circadian alignment, pineal gland receptor stimulation, and systemic free-radical scavenging in liquid format |
| Epithalon | Synthetic Tetrapeptide Bioregulator (Ala-Glu-Asp-Gly) | Induces telomerase enzyme activity and elongation in somatic cell lines while resetting pineal gland output | Focuses on cellular senescence, telomere length restoration, and long-term pineal circadian rhythm regulation |
| Selank | Tuftsin-Derived Synthetic Heptapeptide | Stabilizes central enkephalins, increases BDNF expression, and modulates GABAergic neurotransmission | Focuses on non-sedating emotional stress buffering, cognitive activation, and immunomodulatory neuropeptide research |
Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and reference peptides. Every batch of DSIP undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ purity, correct nonapeptide sequence identity (WAGGDASGE), and complete absence of unreacted amino acid fragments or heavy metals.
DSIP is an amphiphilic nonapeptide consisting of nine amino acids: L-tryptophyl-L-alanylglycylglycyl-L-α-aspartyl-L-alanyl-L-seryl-glycyl-L-glutamic acid (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu). Its chemical formula is C35H48N10O15 with a molecular weight of 848.81 g/mol.
DSIP interacts with central neuropeptide receptors in the thalamus and hypothalamus to synchronize cortical neuron firing rates, selectively increasing low-frequency delta-wave (0.5–4 Hz) power density on EEG recordings without suppressing REM phase intervals.
The HPA axis triggers excessive adrenocorticotropic hormone (ACTH) and corticosterone release. DSIP dampens CRH-mediated signaling, restoring basal ACTH levels and protecting cells from hyper-cortisolemic damage.
Lyophilized DSIP dissolves rapidly in reagent solutions designed with preservatives.
The Amino Acid Blends work through MT1/MT2 suprachiasmatic receptors to regulate light-dark circadian phase shifts in a pre-solubilized liquid matrix. DSIP is a lyophilized neuropeptide that specifically modulates slow-wave δ-wave sleep architecture and HPA axis stress responses.
Studies indicate that DSIP does not bind direct sedative GABA-A benzodiazepine sites. Because it functions as a physiological neuromodulator, repeated administration in animal assays does not trigger receptor downregulation, tolerance, or withdrawal rebound effects.
Unopened lyophilized DSIP vials should be stored frozen at -20°C for long-term preservation. Protect from direct light, heat, and moisture. Once transformed into an aqueous solution, store refrigerated between 2°C and 8°C and use within designated laboratory testing windows.
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