Aminotadalafil (Amino Tadalafil) is a synthetic N-amino substituted β-carboline derivative (CAS 385769-84-6) that functions as a potent, selective phosphodiesterase type 5 (PDE5) inhibitor. It competitively binds the active site catalytic domain of PDE5 to prevent cGMP hydrolysis, elevating intracellular second-messenger concentrations and driving PKG-mediated vascular relaxation in cellular research models.
$48.00
| Quantity | Discounted Price |
|---|---|
| 3 - 5 | $45.60 |
| 6 - 8 | $44.64 |
| 9 + | $43.20 |
Aminotadalafil (known chemically as Amino Tadalafil or (6R,12aR)-2-amino-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione) is a synthetic β-carboline derivative featuring an N-amino modification on its diketopiperazine core. Classified as a selective phosphodiesterase type 5 (PDE5) inhibitor reference compound, Aminotadalafil targets catalytic zinc-binding domains within PDE enzymes to stabilize intracellular cyclic guanosine monophosphate (cGMP) pools.
Formulated and analytical batch-verified for Modern Aminos, Aminotadalafil is supplied as a high-purity solid reference material for laboratory analytical screening, HPLC method development, and competitive enzyme binding assays. Researchers investigating PDE isoform selectivity, mass spectrometry fragmentation patterns, and vascular smooth muscle relaxation pathways utilize Aminotadalafil alongside related structural analogs offered on the site, such as Nortadalafil.
| Compound Name | Aminotadalafil |
|---|---|
| Format & Packaging | Analytical-Grade Reference Powder / Sealed Glass Reagent Vial |
| Synonyms / Alt Names | Amino Tadalafil, Tildenafil Impurity 18, N-Desmethyl N-Amino Tadalafil |
| CAS Number | 385769-84-6 |
| Chemical Formula | C21H18N4O4 |
| Molecular Weight | 390.40 g/mol |
| IUPAC Name | (6R,12aR)-2-amino-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione |
| InChIKey | VUKJGAVIWMPOOJ-FOIQADDNSA-N |
| SMILES Code | NN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O |
The biochemical pathways and cellular targets of Aminotadalafil in laboratory research include:
When evaluating research efficacy and published scientific literature for Aminotadalafil:
To evaluate chemical modifications, polar surface area, and receptor kinetics, researchers compare Aminotadalafil against related β-carboline analogs available at Modern Aminos:
| Compound / Reference | Chemical Structure & Formula | Core Structural Modification | Research Profile & Focus |
|---|---|---|---|
| Aminotadalafil | C21H18N4O4 (MW 390.40 g/mol) | N-amino substitution on the diketopiperazine ring (-NH2 group) | Focuses on PDE5 inhibition, increased polar surface area, and analytical reference profiling for N-amino substituted β-carbolines |
| Nortadalafil | C21H17N3O4 (MW 375.38 g/mol) | N-demethylated secondary amine structure (-NH group on diketopiperazine ring) | Focuses on evaluating un-substituted diketopiperazine hydrogen bonding, secondary amine lipophilicity, and demethylated metabolite pathway kinetics |
Aminotadalafil is a synthetic β-carboline derivative incorporating a fused pyrazinedione ring. Its defining structural feature is an amino group (-NH2) attached to the nitrogen atom of the diketopiperazine ring, yielding the chemical formula C21H18N4O4.
Aminotadalafil competitively inhibits the phosphodiesterase type 5 (PDE5) enzyme. By blocking PDE5-mediated cGMP hydrolysis, Aminotadalafil maintains elevated cellular cGMP concentrations, supporting protein kinase G (PKG) activation and downstream nitric oxide-mediated vascular smooth muscle relaxation.
Aminotadalafil features an N-amino group (-NH2) attached to the diketopiperazine ring nitrogen atom. In contrast, Nortadalafil is an N-desmethyl derivative possessing an un-substituted secondary amine (-NH) at that same nitrogen position, altering the molecular weight (390.40 g/mol vs 375.38 g/mol) and polar surface area.
Aminotadalafil is widely used as a certified reference standard in high-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS/MS), and nuclear magnetic resonance (NMR) spectroscopy. These methods establish baseline mass fragmentation patterns and retention times for analytical reference profiling. Read more about our Quality Assurance Program.
Aminotadalafil provided by Modern Aminos is strictly for laboratory, in vitro, and analytical research use only (RUO). It is not approved for human or animal consumption. Solid reference samples should be stored sealed in a dry, dark place under frozen conditions (-20°C) to ensure long-term chemical stability.
The products offered by Modern Aminos are intended strictly for laboratory research purposes only and are sold exclusively to qualified professionals, institutions, and entities. These products are not for human consumption, veterinary use, or any other application involving living organisms, including but not limited to diagnostic, therapeutic, or recreational purposes.
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Modern Aminos does not claim that this product is approved by the U.S. Food and Drug Administration (FDA) for any purpose. The statements regarding this product have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
The buyer assumes full responsibility for ensuring the safe handling, storage, and use of this product. Modern Aminos is not liable for any damages, direct or indirect, resulting from improper handling, storage, or unauthorized use of this product. Furthermore, Modern Aminos reserves the right to refuse sales to any individual or entity suspected of misusing its products.
If you have questions about the safe and lawful use of this product, consult a qualified professional with expertise in laboratory research. By proceeding with this purchase, you agree to these terms and conditions.
