ACE-167

ACE-167 is a VDAC1-derived small molecule peptide for research into mitochondrial cholesterol transport and endocrine biosynthetics. Strict laboratory use only.

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Product Overview

ACE-167 is an advanced, voltage-dependent anionic channel 1 (VDAC1)-derived small molecule peptide fragment engineered for specialized biochemical and laboratory assays. Developed originally from structural frameworks identified by Acesis BioMed US, Inc., this compound serves as a vital tool for exploring mitochondrial membrane dynamics and structural stability in oral peptide research designs. By providing a highly stable and structurally minimized model, ACE-167 allows investigators to evaluate molecular pathways without the rapid enzymatic degradation typically associated with larger peptide sequences.

Mechanism of Action

In biochemical systems, the transport of cholesterol across mitochondrial membranes serves as a critical rate-limiting step in the biosynthesis of downstream compounds and steroid families. ACE-167 functions as a highly targeted laboratory agent designed to interact with outer mitochondrial membrane complexes:

Mitochondrial Interaction: The peptide targets VDAC1, a key channel component located in the outer mitochondrial membrane that is involved in cellular energetic and transport protein complexes.
Protein-Protein Blockade: Research models demonstrate that blocking the interaction of VDAC1 with corresponding binding proteins modulates standard transport cascades.
Downstream Biomarker Regulation: In animal research models, administration of these small peptide fragments has been shown to induce measurable changes in circulating markers, including elevations in testosterone and luteinizing hormone, alongside down-regulation of corticosterone.

Comparative Chemical Profiles

While studied under the designation ACE-167, academic literature and patent documentation examine several short-chain candidates (ranging from 4–7 amino acids) that match this profile:

Candidate Sequence	Plasma Stability / Half-Life	Research Observations
RdVTQ	~2 hours	Features an unnatural D-valine substitution for enhanced stability. It represents the most heavily documented structural candidate under this profile.
Ac-RITQdS-NH₂	>5 hours	Demonstrates prolonged compound availability and high stability in active assays, though corresponding biomarker spikes appeared transient.
KVSQ	~10 minutes	Exhibits high clearance and low plasma stability, serving primarily as a comparative baseline in transient exposure models.

References

Oral administration of VDAC1-derived small molecule peptides increases circulating testosterone levels in male rats

Laboratory Specifications & Storage

Core Structure: Short-chain VDAC1-derived peptide fragment.
Research Reference: Covered extensively under global patent classification [WO 2020/093142 A1] regarding small peptide structural dynamics.
Storage Conditions: To preserve structural integrity and prevent degradation, store in a cool, dry place away from direct light. Long-term storage should be maintained at sub-zero temperatures (-20°C).

Research Notice:

This product is synthesized and distributed strictly for in vitro laboratory research, development, and analytical testing. It is not intended, approved, or safe for human or veterinary use, therapeutic administration, or consumption. All handling must be performed exclusively by qualified professionals within a verified research facility.

The products offered by Modern Aminos are intended strictly for laboratory research purposes only and are sold exclusively to qualified professionals, institutions, and entities. These products are not for human consumption, veterinary use, or any other application involving living organisms, including but not limited to diagnostic, therapeutic, or recreational purposes.

By purchasing this product, you confirm that:

You are a qualified professional or entity with the necessary knowledge, training, and facilities to handle chemical reagents safely and appropriately.
You will use this product in full compliance with all applicable local, state, and federal laws and regulations.

Prohibited Uses

This product is not to be used as an active pharmaceutical ingredient (API) in compounding or manufacturing drugs for human or veterinary use.
It is strictly prohibited to use this product for administration to humans or animals under any circumstances.
Modern Aminos does not condone or permit the use of its products for the development, testing, or production of illegal substances.

Regulatory Compliance

Modern Aminos does not claim that this product is approved by the U.S. Food and Drug Administration (FDA) for any purpose. The statements regarding this product have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Liability Statement

The buyer assumes full responsibility for ensuring the safe handling, storage, and use of this product. Modern Aminos is not liable for any damages, direct or indirect, resulting from improper handling, storage, or unauthorized use of this product. Furthermore, Modern Aminos reserves the right to refuse sales to any individual or entity suspected of misusing its products.

If you have questions about the safe and lawful use of this product, consult a qualified professional with expertise in laboratory research. By proceeding with this purchase, you agree to these terms and conditions.