Transdermal Pentadecapeptide (Body Protection Compound / Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) is a 15-amino-acid synthetic pentadecapeptide formulated within an advanced lipid-permeation transdermal carrier. Engineered to cross the hydrophobic stratum corneum barrier without systemic distribution loss, Transdermal Pentadecapeptide facilitates localized extracellular matrix (ECM) remodeling, tenocyte migration via FAK/paxillin signaling, and microvascular endothelial tube formation via VEGFR2 activation.
$67.00
In stock
| Quantity | Discounted Price |
|---|---|
| 4 - 6 | $64.32 |
| 7 - 9 | $62.98 |
| 10 + | $61.64 |
Transdermal Pentadecapeptide is a specialized topical and transdermal analytical formulation containing the 15-amino-acid stable gastric pentadecapeptide (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) embedded within an advanced lipid-based permeation carrier.
While conventional peptide research relies on aqueous system kinetics, transdermal peptide modeling evaluates the transport of intact macromolecular compounds across the hydrophobic lipid bilayers of the stratum corneum. Formulated with specialized transdermal penetration enhancers, Transdermal pentadecapeptide delivers high concentrations of active peptide monomers directly to localized dermal, subcutaneous, fascial, and tendon tissue preparations.
Once translocated across the cutaneous barrier, pentadecapeptide initiates localized tissue cytoprotection and architectural repair by activating vascular endothelial growth factor receptor 2 (VEGFR2), upregulating the focal adhesion kinase (FAK)/paxillin pathway in fibroblasts, and balancing local nitric oxide (NO) generation.
Batch-verified for exact peptide concentration and chromatographic purity at Modern Aminos, Transdermal Pentadecapeptide is offered as a standardized transdermal reference material. Researchers evaluate this localized delivery matrix alongside complementary tissue remodeling and cytoprotective reference standards available on the site, such as Pentadecapeptide, GHK-Cu, Thymosin Beta-4, KPV, and Lyophilized blends containing both pentadecapeptide and Thymosin Beta-4.
| Compound Name | Transdermal Pentadecapeptide (Body Protection Compound-157) |
|---|---|
| Formulation / Delivery Matrix | Permeation-Enhanced Liposomal / Transdermal Research Matrix |
| Peptide Sequence | Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val |
| Synonyms / Alt Names | Transdermal Body Protection Compound, Bepecin, PL 14736, PL-10 |
| CAS Number | 137525-51-0 |
| Chemical Formula | C62H98N16O22 |
| Molecular Weight | 1419.53 g/mol |
| Primary Cellular Targets | VEGFR2 Phosphorylation, FAK-Paxillin Axis, eNOS / iNOS Synthesis |
| InChIKey |
HEEWEZGQMLZMFE-RKGINYAYSA-N
|
| SMILES Code |
C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]3CCCN3C(=O)[C@@H]4CCCN4C(=O)[C@H](CCC(=O)O)NC(=O)CN
|
The biochemical pathways and localized cellular targets of Transdermal Pentadecapeptide in laboratory research include:
When evaluating published scientific literature for pentadecapeptide:
To evaluate delivery kinetics, tissue localization, and target specificity, researchers compare Transdermal Pentadecapeptide against alternative reference standards available at Modern Aminos:
In cellular and animal tissue research, route of administration dictates tissue concentrations and pharmacokinetic distribution:
| Compound / Reference | Delivery Format & Class | Core Mechanism of Action | Primary Research Focus |
|---|---|---|---|
| Transdermal Pentadecapeptide | Permeation-Enhanced Transdermal Matrix | Local stratum corneum diffusion; VEGFR2 activation; FAK/paxillin tenocyte migration | Site-specific epidermal, dermal, and subdermal cellular modulation; localized cutaneous permeation kinetics |
| Lyophilized Pentadecapeptide | Aqueous / Systemic Pentadecapeptide | Systemic VEGFR2 upregulation; gastric cytoprotection; nitric oxide synthase modulation | Systemic multi-organ cytoprotection, gastrointestinal mucosal modulation, and vascular regeneration |
| GHK-Cu (Topical) | Copper-Chelated Tripeptide (Gly-His-Lys) | Stimulates pro-collagen, elastin, and decorin gene transcription; activates SOD1 antioxidant defense | Dermal rejuvenation, epidermal restoration, ECM remodeling, and broad-spectrum extracellular matrix synthesis |
| TB-500 | Thymosin β4 Active Domain Peptide | Sequestration of monomeric G-actin to drive rapid cell motility, migration, and tissue re-epithelialization | Cytoskeletal remodeling and actin-mediated cell motility |
Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and specialized peptide delivery systems. Every batch undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify 98%+ peptide purity, precise active compound concentration, permeation vehicle stability, and complete absence of heavy metals, residual solvents, or synthesis contaminants.
Transdermal Pentadecapeptide is an advanced topical formulation containing pure 15-amino-acids embedded in a specialized lipid carrier designed to transport intact peptide molecules across the hydrophobic stratum corneum barrier into local target tissues.
The transdermal carrier temporarily modulates intercellular lipid fluidity in the upper epidermal layers, enabling the 1419.53 g/mol pentadecapeptide to diffuse passively into subcutaneous and fascial compartments directly beneath the site of application.
Pentadecapeptide activates VEGFR2 to drive microvascular angiogenesis, stimulates FAK and paxillin phosphorylation to accelerate tenocyte and fibroblast migration, and modulates nitric oxide (NO) generation to stabilize local tissue perfusion.
Transdermal Pentadecapeptide delivers high concentrations of active peptide directly to specific peripheral joints, tendons, and connective tissues without systemic distribution loss, whereas systemic Pentadecapeptide distributes broadly across vascular, visceral, and gastrointestinal targets.
Pentadecapeptide primarily targets microvascular VEGFR2 angiogenesis and FAK/paxillin-mediated tendon/fascial repair. GHK-Cu functions as a copper-dependent transcriptional regulator focusing on pro-collagen synthesis, decorin expression, and broad extracellular matrix remodeling.
Modern Aminos uses High-Performance Liquid Chromatography (HPLC) to verify active peptide purity exceeding 98% and Mass Spectrometry (MS) to confirm exact molecular mass (1419.53 g/mol) and concentration parameters prior to batch release.
Transdermal Pentadecapeptide should be stored tightly sealed in a cool, dry environment (15°C to 25°C) or refrigerated, protected from direct sunlight, UV exposure, and excessive heat to maintain the stability of both the peptide and the transdermal lipid matrix.
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