MariTide (Maridebart Cafraglutide / AMG 133)

Research Grade Chemical for Laboratory Use Only

Product Short Description

MariTide (Maridebart Cafraglutide / AMG 133) is a first-in-class bispecific peptide-antibody conjugate (PAC) engineered for advanced metabolic research. By combining a GLP-1 receptor agonist with a GIP receptor antagonist on a human IgG antibody backbone, this long-acting molecule is designed to modulate signaling pathways involved in satiety and lipid metabolism with a prolonged pharmacokinetic profile.

Product Description

Maridebart Cafraglutide, widely recognized in literature as MariTide (or AMG 133), represents a significant evolution in peptide engineering. Unlike standard synthetic peptides that are rapidly cleared by the kidneys, MariTide is a Peptide-Antibody Conjugate (PAC). This structural integration allows the molecule to utilize the body’s natural FcRn (neonatal Fc receptor) recycling pathway, which diverts the compound from cellular degradation and extends its half-life significantly.

Mechanism of Action

MariTide operates through a “dual-pathway” interaction designed to study metabolic homeostasis:

GLP-1 Receptor Activation: The peptide component binds to GLP-1 receptors, triggering signaling pathways associated with appetite regulation and glycemic control.
GIP Receptor Antagonism: The antibody component specifically blocks the GIP receptor. By inhibiting this pathway, research suggests it may target peripheral adipose tissue and influence lipid accumulation.

Research Applications

This compound is intended for in vitro and in vivo experimental models focusing on:

Neuro-endocrine signaling pathways and satiety regulation.
The interplay between GLP-1 agonism and GIPR antagonism.
Pharmacokinetic studies of peptide-antibody conjugates vs. conventional peptides.
Metabolic markers in adipose tissue research.

Chemical and Molecular Analysis

Attribute	Specification
Compound Name	Maridebart Cafraglutide (MariTide / AMG 133)
Classification	Bispecific Peptide-Antibody Conjugate (PAC)
Structure	Human IgG antibody backbone covalently conjugated to two lipidated GLP-1 receptor agonist peptides
Primary Targets	GLP-1 Receptor (Agonist) / GIP Receptor (Antagonist)
Pharmacokinetics	Engages FcRn recycling pathway; terminal half-life of ~21 days
Storage	Must be stored at recommended laboratory temperatures to maintain protein structural integrity

Reference Materials

Disclaimer: This product is intended strictly for research and laboratory use only. It is not approved for human consumption, use in any clinical setting, or medical diagnostics. Users must adhere to institutional biosafety and ethical research guidelines.

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Prohibited Uses

This product is not to be used as an active pharmaceutical ingredient (API) in compounding or manufacturing drugs for human or veterinary use.
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Regulatory Compliance

Modern Aminos does not claim that this product is approved by the U.S. Food and Drug Administration (FDA) for any purpose. The statements regarding this product have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Liability Statement

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