Hexarelin (Examorelin / His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys-NH2) is a growth hormone secretagogue (GHRP) engineered for somatotropic axis and scavenger receptor research. Demonstrating high affinity for the Gq/11-coupled Growth Hormone Secretagogue Receptor (GHSR-1a), Hexarelin activates the PLC/IP3/Ca2+ cascade in anterior pituitary somatotropes, functions as a selective agonist for the CD36 scavenger receptor, and mediates cytoprotective and anti-apoptotic signaling in myocardial and microvascular cell lines.
$68.00
In stock
| Quantity | Discounted Price |
|---|---|
| 4 - 6 | $65.28 |
| 7 - 9 | $63.92 |
| 10 + | $62.56 |
Hexarelin (known chemically as Examorelin or His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys-NH2) is a synthetic hexapeptide growth hormone (GH) secretagogue derived from the growth hormone-releasing peptide (GHRP) family. Structurally stabilized by non-natural amino acid substitutions—specifically D-2-methyltryptophan and D-phenylalanine—Hexarelin displays elevated stability against enzymatic degradation compared to native ghrelin.
Operating across neuroendocrine somatotropic pathways, Hexarelin functions as a potent agonist at the Gq/11-protein coupled Growth Hormone Secretagogue Receptor 1a (GHSR-1a) on anterior pituitary somatotropes. Receptor occupancy activates Phospholipase C (PLC), stimulating the cleavage of phosphatidylinositol 4,5-bisphosphate into inositol trisphosphate (IP3) and diacylglycerol (DAG). The resulting intracellular calcium (Ca2+) mobilization drives rapid exocytosis of stored GH secretory granules, producing an acute, high-amplitude secretory wave in adenohypophyseal cell models.
In addition to its somatotropic activity, Hexarelin possesses high affinity for the scavenger receptor CD36 (fatty acid translocase). Expressed throughout myocardial and vascular endothelial tissues, CD36 ligation by Hexarelin initiates cytoprotective and anti-apoptotic kinase cascades, mitigating cellular damage in cardiac ischemia-reperfusion models and preserving mitochondrial integrity.
Batch-verified for high analytical purity and mass accuracy to buy Hexarelin at Modern Aminos, Hexarelin is offered as a standardized 10MG lyophilized dry solid in a 2R glass vial. Researchers evaluating somatotrope secretory amplitude, receptor tachyphylaxis kinetics, and CD36 signaling cascades study Hexarelin alongside complementary reference standards available on the site, such as Sermorelin, Ipamorelin, and MK-677.
| Compound Name | Hexarelin (Examorelin) |
|---|---|
| Format / Quantity | 10MG Lyophilized Dry Powder in 2R Glass Vial |
| Biological Target | Somatotropic Axis / Pituitary GHSR-1a & Myocardial CD36 Scavenger Receptors |
| Chemical Classification | Synthetic Hexapeptide GH Secretagogue (GHRP Analogue) |
| Peptide Sequence | His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys-NH2 |
| Synonyms / Alt Names | Examorelin, EP-23959, Hexapeptide Releasing Hormone |
| CAS Number | 140703-51-1 |
| Chemical Formula | C47H58N12O6 |
| Molecular Weight | 887.05 g/mol |
| Primary Signal Transduction | Gq/11 → PLC → IP3 / DAG → Intracellular Ca2+ Efflux |
| Physical Appearance | White Lyophilized Solid Cake |
The biochemical pathways and cellular targets of Hexarelin in laboratory research include:
When evaluating published scientific literature and endocrine monographs for Hexarelin:
In somatotropic and neuroendocrine research, growth hormone secretagogues differ across receptor binding affinities, second-messenger pathways, and secondary tissue interactions:
| Compound / Reference | Chemical Structure & Class | Primary Receptor Targets | Primary Research Profile |
|---|---|---|---|
| Hexarelin | Synthetic Hexapeptide (6 Amino Acids) | Pituitary GHSR-1a & Myocardial CD36 Receptors | Highest peak secretory amplitude; dual GHSR-1a/CD36 signaling; rapid receptor desensitization modeling |
| GHRP-2 | Synthetic Hexapeptide (6 Amino Acids) | Pituitary & Hypothalamic GHSR-1a | Robust pulsatile GH release; intermediate receptor desensitization; minor prolactin/ACTH co-secretion |
| GHRP-6 | Synthetic Hexapeptide (6 Amino Acids) | Pituitary GHSR-1a & Hypothalamic Ghrelin Targets | Pulsatile GH secretion paired with central orexigenic pathway activation |
| Sermorelin | Native GHRH Fragment (29 Amino Acids) | Pituitary Somatotrope GHRH-R | GHRH-R agonism (cAMP/PKA); stimulates GH mRNA transcription and baseline endocrine signaling |
| MK-677 | Non-Peptide Spiroindoline Small Molecule | Pituitary & Hypothalamic GHSR-1a | Continuous, long-duration GHSR-1a occupancy; extended IGF-1 and somatotropic axis stimulation |
Yes, Modern Aminos is a highly trusted vendor for analytical-grade research chemicals and reference peptides. Every batch of Hexarelin 10MG undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to confirm minimum 98%+ active chemical purity, exact hexapeptide sequence stoichiometry, verified molecular weight (887.05 g/mol), and complete absence of heavy metals or synthesis impurities.
Hexarelin (Examorelin) is a synthetic hexapeptide growth hormone secretagogue composed of the sequence His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys-NH2. It is classified as an atypical GHRP that selectively engages both the GHSR-1a receptor and the CD36 scavenger receptor.
Hexarelin binds GHSR-1a receptors on pituitary somatotropes, activating Gq/11 proteins and Phospholipase C. This stimulates the IP3-mediated release of stored intracellular calcium (Ca2+) from the endoplasmic reticulum, driving the rapid exocytosis of growth hormone storage granules.
Beyond its somatotropic activity, Hexarelin binds the CD36 scavenger receptor on cardiac and endothelial cell membranes. This interaction initiates anti-apoptotic and metabolic signaling cascades, protecting myocardial cells from ischemic damage independently of growth hormone release.
Modern Aminos supplies analytical-grade Hexarelin as a 10MG lyophilized dry solid cake in a sterile 2R glass vial, ensuring solid-state peptide stability and precise gravimetric mass control for benchtop research assays.
Hexarelin induces rapid tachyphylaxis in cell models, meaning repeated exposure leads to receptor internalization and down-regulation of GH release. This characteristic makes it a valuable research tool for studying secretagogue receptor downregulatory dynamics.
Modern Aminos utilizes High-Performance Liquid Chromatography (HPLC) to verify active chemical purity exceeding 98% and Mass Spectrometry (MS) to verify the exact molecular mass (887.05 g/mol) and hexapeptide sequence stoichiometry prior to batch release.
Lyophilized Hexarelin glass vials should be stored tightly sealed in a cool, dry environment (15°C to 25°C) or refrigerated (2°C to 8°C) for long-term preservation. Protect from direct sunlight, thermal extremes, and atmospheric moisture to maintain solid-state peptide stability.
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