Thymosin Alpha-1 (TA-1) is a 28-amino-acid acetylated polypeptide originally isolated from thymic tissue extract. Operating as a master modulator of adaptive and innate immunity, Thymosin Alpha-1 agonizes Toll-Like Receptors (TLR2 and TLR9) on dendritic cells, promotes the differentiation of CD34+ progenitor cells into mature CD4+ and CD8+ T lymphocytes, and upregulates Th1 cytokine expression (IFN-γ, IL-2). Modern Aminos supplies analytical-grade Thymosin Alpha-1 in a 10MG lyophilized dry solid 2R glass vial format strictly for in vitro laboratory research, lymphocyte differentiation assays, and immune bioenergetics screening.
$80.00
$56.00
| Quantity | Discounted Price |
|---|---|
| 4 - 6 | $31.49 |
| 7 - 9 | $30.83 |
| 10 + | $30.18 |
Thymosin Alpha-1 (commonly abbreviated as TA-1 or Thymalfasin) is an acetylated 28-amino-acid polypeptide hormone originally isolated from thymic fraction V. Synthesized to replicate the primary active sequence of endogenous thymosin, Thymosin Alpha-1 functions as a major humoral factor governing T-cell development and cellular immunocompetence.
Operating across both innate and adaptive arms of the immune system, Thymosin Alpha-1 binds Toll-Like Receptors (primarily TLR2 and TLR9) on immature myeloid dendritic cells and macrophages, activating MyD88-dependent signaling cascades. This interaction stimulates the maturation of thymic CD34+ progenitor cells into functional CD4+ helper and CD8+ cytotoxic T lymphocytes, drives Th1-type cytokine production (including interferon-gamma and interleukin-2), and upregulates major histocompatibility complex (MHC) Class I presentation on target cell membranes.
Batch-verified for high analytical purity at Modern Aminos, Thymosin Alpha-1 (TA-1) is offered as a 10MG lyophilized dry solid in a 2R glass vial. Researchers evaluating lymphocyte proliferation kinetics, dendritic cell costimulatory expression, and antiviral cellular defense study Thymosin Alpha-1 alongside complementary immunomodulatory and bioregulatory reference standards available on the site, such as KPV, LL-37, Glutathione, and Chonluten.
| Compound Name | Thymosin Alpha-1 (TA-1 / Thymalfasin) |
|---|---|
| Format / Quantity | 10MG Lyophilized Dry Powder in 2R Glass Vial |
| Biological Target | Thymic Lymphoid Tissue & Innate/Adaptive Immune Receptors (TLR2 / TLR9) |
| Chemical Classification | Acetylated Synthetic Polypeptide (Thymic Hormone Analogue) |
| Peptide Sequence | Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH |
| Synonyms / Alt Names | Thymalfasin, TA1, Tα1, Thymosin α1, Zadaxin Synthetic Analogue |
| CAS Number | 69521-94-4 |
| Chemical Formula | C129H215N33O45 |
| Molecular Weight | 3108.3 g/mol |
| IUPAC Name | N-acetyl-L-seryl-L-alpha-aspartyl-L-alanyl-L-alanyl-L-valyl-L-alpha-aspartyl-L-threonyl-L-seryl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-threonyl-L-threonyl-L-lysyl-L-alpha-aspartyl-L-leucyl-L-lysyl-L-alpha-glutamyl-L-lysyl-L-lysyl-L-alpha-glutamyl-L-valyl-L-valyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alanyl-L-alpha-glutamyl-L-asparagine |
| InChIKey | InChIKey=NZVYCXVTEHPMHE-WTRFZTBJNA-N |
| SMILES Code | Protected Polypeptide Sequence Matrix |
The biochemical pathways and cellular targets of Thymosin Alpha-1 in laboratory research include:
When evaluating published scientific literature and immunological monographs for Thymosin Alpha-1 (TA-1):
To evaluate receptor targets, peptide length, and immune pathway specificity, researchers compare Thymosin Alpha-1 against alternative immunomodulating standards available at Modern Aminos:
| Compound / Reference | Chemical Structure & Class | Primary Mechanistic Target | Primary Research Focus |
|---|---|---|---|
| Thymosin Alpha-1 (TA-1) | 28-Amino-Acid Acetylated Polypeptide | TLR2 / TLR9 agonist; stimulates TdT, CD4+/CD8+ maturation, and Th1 cytokine polarization | Thymic lymphocyte differentiation, dendritic cell activation, adaptive immune defense, and NK cell kinetics |
| KPV | Synthetic Tripeptide Fragment (Lys-Pro-Val) | Inhibits IκB phosphorylation and blocks NF-κB nuclear translocation | Targeted anti-inflammatory cytokine suppression (TNF-α, IL-6) and mucosal epithelial protection |
| LL-37 | 37-Amino-Acid Cathelicidin Peptide | Disrupts bacterial cell membranes; binds formyl peptide receptors (FPR2) to direct chemotaxis | Direct antimicrobial membrane disruption, innate immune activation, and LPS neutralization |
Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and reference peptides. Every batch of Thymosin Alpha-1 10mg undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ chemical purity, exact 28-amino-acid sequence fidelity, correct molecular weight (3108.3 g/mol), and complete absence of heavy metals or synthesis impurities.
Thymosin Alpha-1 is a synthetic 28-amino-acid polypeptide (Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN-OH) featuring an N-terminal acetyl group. It replicates the active peptide hormone naturally produced in the thymic gland.
Thymosin Alpha-1 binds TLR2 and TLR9 on dendritic cells, initiating MyD88-dependent signaling pathways that stimulate dendritic cell maturation, antigen processing, and costimulatory molecule (CD80/CD86) expression.
Modern Aminos supplies analytical-grade Thymosin Alpha-1 as a 10MG lyophilized dry solid in a sterile 2R glass vial, ensuring solid-state stability and precise gravimetric mass control for benchtop research assays.
TA-1 stimulates terminal deoxynucleotidyl transferase (TdT) activity to drive the maturation of immature thymic stem cells into functional CD4+ helper and CD8+ cytotoxic T lymphocytes, maintaining CD4+/CD8+ homeostasis.
Thymosin Alpha-1 (28 AA) operates via membrane TLR2/TLR9 activation and T-cell differentiation. Crystagen (Pro-Glu-Asp) is a short tripeptide acting epigenetically on thymic chromatin. KPV (Lys-Pro-Val) acts specifically to block NF-κB and suppress inflammatory cytokines.
Modern Aminos utilizes High-Performance Liquid Chromatography (HPLC) to confirm active chemical purity exceeding 98% and Mass Spectrometry (MS) to verify exact molecular weight (3108.3 g/mol) and 28-amino-acid sequence fidelity prior to batch release.
Lyophilized Thymosin Alpha-1 glass vials should be stored tightly sealed in a cool, dry environment (15°C to 25°C) or refrigerated for long-term preservation. Protect from direct light, heat exposure, and atmospheric moisture to maintain solid-state peptide stability.
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