Selank & Semax (10MG/10MG) is a dual-heptapeptide reference blend combining the neurogenic actions of Semax (ACTH(4-10) derivative) with the anxiolytic and immunomodulatory properties of Selank (Tuftsin derivative). Semax upregulates Brain-Derived Neurotrophic Factor (BDNF) and stimulates TrkB receptor phosphorylation, while Selank allosterically modulates GABAA receptors and inhibits enkephalin-degrading enzymes.
Original price was: $78.00.$58.50Current price is: $58.50.
In stock
| Quantity | Discounted Price |
|---|---|
| 3 - 5 | $56.16 |
| 7 - 10 | $54.99 |
| 9 + | $53.82 |
The NA-Semax/NA-Selank Research Complex is a dual-heptapeptide analytical formulation combining two of the most widely investigated synthetic regulatory peptides in neuro-biochemical research: Semax (10MG) and Selank (10MG). Developed to study synergistic central nervous system modulation, this combination couples an adrenocorticotropic hormone fragment analogue with an extended tuftsin immunomodulatory analogue.
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) acts primarily as a cognitive and neuro-restorative peptide, upregulating Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) while stimulating TrkB receptor cascades and optimizing dopaminergic/serotonergic turnover. Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) functions as an allosteric modulator of GABAA receptor complexes, inhibiting endogenous enkephalin breakdown to attenuate anxiety-like stress responses without sedative depression.
In modern neurochemical modeling, researchers evaluate standard unmodified sequences alongside specialized terminal modifications, including N-Acetyl Semax (NA-Semax), N-Acetyl Selank (NA-Selank), amidated versions, dual-modified NA-Semax Amidate (NA-Semax-Amidate) and NA-Selank Amidate (NA-Selank-Amidate), and advanced adamantyl-conjugated derivatives such as Adamax and Adalank.
Batch-verified for high analytical purity at Modern Aminos, this complex is supplied as a lyophilized dry solid in a 2R glass vial. Investigators study this dual-peptide matrix alongside complementary neuro-active standards available on the site, such as Nooglutyl, Bromantane, 9-Me-BC, and NSI-189 Phosphate.
| Parameter | Semax Component | Selank Component |
|---|---|---|
| Compound Name | Semax (ACTH(4-10) Analogue) | Selank (Tuftsin Analogue) |
| Vial Content | 10MG Lyophilized Dry Powder | 10MG Lyophilized Dry Powder |
| Peptide Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
Thr-Lys-Pro-Arg-Pro-Gly-Pro |
| CAS Number | 80714-61-0 | 129954-34-3 |
| Chemical Formula | C37H51N9O10S | C33H57N11O9 |
| Molecular Weight | 813.92 g/mol | 751.87 g/mol |
| Primary Target | BDNF / TrkB & Dopaminergic Signaling | GABAA Receptors & Enkephalinase Inhibition |
| Structure Class | Synthetic Heptapeptide Analogue | Synthetic Heptapeptide Analogue |
The dual biochemical pathways and neuro-regulatory targets of NA-Semax/NA-Selank Research Complex in laboratory research include:
When evaluating research efficacy and published scientific literature for Semax & Selank:
In peptide chemistry, terminal end-capping and side-chain conjugations significantly alter enzyme degradation kinetics, lipophilicity, and membrane translocation:
| Variant / Analogue Class | N-Terminal State | C-Terminal State | Pharmacokinetic & Research Profile |
|---|---|---|---|
| Native / Standard (Offered Here) | Free Amine (H2N-) | Free Carboxyl (-COOH) | Standard baseline reference; rapid clearance kinetics, zero synthetic terminal additions |
| N-Acetyl (NA-Semax / NA-Selank) | Acetylated (Ac-) | Free Carboxyl (-COOH) | Protects against aminopeptidase cleavage; enhances lipophilicity and mucosal barrier transport |
| Amidate (Semax / Selank Amidate) | Free Amine (H2N-) | Amidated (-CONH2) | Protects against carboxypeptidases; removes C-terminal negative charge for altered receptor kinetics |
| Dual-Capped (Adamax / Adalank / NA-Semax Amidate / NA-Selank Amidate) | Acetylated (Ac-) | Amidated (-CONH2) | Full terminal protection; resists both amino- and carboxypeptidases for maximum in vitro half-life |
Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and reference peptides. Every batch of the Selank & Semax dual-peptide complex undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ chemical purity for both heptapeptides, exact 10MG/10MG mass stoichiometry, correct molecular weights (Semax: 813.92 g/mol, Selank: 751.87 g/mol), and complete absence of synthesis impurities.
The NA-Semax/NA-Selank Research Complex is a combined analytical standard containing Semax (an ACTH(4-10) analogue) and Selank (a Tuftsin analogue) in a single lyophilized 2R glass vial designed for simultaneous neuro-chemical pathway evaluation. There are versions that contain N-Acetylated, N-Acetyl-Amidated, non-Acetylated, and non-Amidate variations in this research blend to allow for different research
Semax stimulates the expression of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF), activates TrkB signaling cascades, and optimizes dopaminergic and serotonergic neurotransmission in cortical and hippocampal neural cell models.
Selank acts as an allosteric modulator of GABAA receptors to balance inhibitory neurotransmission and competitively inhibits enkephalin-degrading enzymes, prolonging endogenous enkephalin signaling to regulate stress and inflammatory pathways.
Native versions possess unmodified N- and C-termini. N-Acetyl versions (NA-Semax / NA-Selank) feature an acetylated N-terminus to resist aminopeptidases. Amidated versions feature a C-terminal carboxamide (-CONH2) to resist carboxypeptidases. Dual-modified versions (NA-Semax Amidate / NA-Selank Amidate) contain both modifications (Ac-[Sequence]-NH2) for full enzymatic protection and extended biological stability.
Adamax (an adamantane-modified Semax derivative) and Adalank (an adamantane-modified Selank derivative) are synthetic structural analogues featuring an attached adamantyl moiety. This lipophilic modification facilitates biological membrane penetration and extends central receptor occupancy in experimental models.
Modern Aminos utilizes High-Performance Liquid Chromatography (HPLC) to resolve both peptide peaks and confirm 98%+ purity, combined with Mass Spectrometry (MS) to verify the individual molecular masses of Semax (813.92 g/mol) and Selank (751.87 g/mol) prior to batch release.
Lyophilized NA-Semax/NA-Selank Research Complex glass vials should be stored tightly sealed in a cool, dry environment (15°C to 25°C) or refrigerated for long-term preservation. Protect from direct heat, light exposure, and atmospheric moisture to maintain solid-state peptide stability.
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