Lipo-C + B12 (Methylated)

Lipo-C + B12 (Methylated)

Lipo-C + B12 (Methylated)

Lipo-C + B12 (Methylated)

Lipo-C + B12 w/ L-Carnitine is an advanced multi-component lipotropic and metabolic amino acid liquid formulation combining L-Carnitine, L-Methionine, L-Inositol, and Choline Bitartrate with active coenzymes Methylcobalamin B12, Pantothenic Acid B5, and Pyridoxine B6 in a stabilized vehicle with 1% Lidocaine and 0.9% Benzyl Alcohol. Engineered to investigate coupled lipid mobilization, Coenzyme A biosynthesis, and transmethylation pathways.

$59.00

In stock

Quantity Discounted Price
4 - 6 $56.64
7 - 9 $55.46
10 + $54.28

What is Lipo-C + B12 w/ L-Carnitine (20mL Amber Vial)?

Lipo-C + B12 w/ L-Carnitine is a high-density, multi-pathway liquid analytical standard formulated in a light-protective 20ML amber glass vial. It combines eight coordinated lipotropic catalysts, essential methyl donors, active B-vitamin coenzymes, and stabilizing agents in an aqueous liquid matrix.

Designed to evaluate converging pathways of lipid mobilization, transmethylation, and cellular bioenergetics, each milliliter delivers:

  • L-Carnitine (200 mg/mL): Quaternary ammonium carrier that mediates long-chain fatty acid transport across the inner mitochondrial membrane via carnitine palmitoyltransferase (CPT-1/CPT-2) for beta-oxidation.
  • L-Methionine (25 mg/mL): Essential sulfur amino acid and rate-limiting precursor for S-adenosylmethionine (SAMe), the primary methyl donor in cellular transmethylation and transsulfuration cascades.
  • L-Inositol / Myo-Inositol (50 mg/mL): Carbocyclic polyol functioning as the structural backbone for inositol phosphate (IP3) second-messenger cascades and cellular phospholipid architecture.
  • Choline Bitartrate (50 mg/mL): Classic lipotropic choline salt providing free choline for phosphatidylcholine biogenesis and very-low-density lipoprotein (VLDL) lipid export.
  • Methylcobalamin / Vitamin B12 (500 mcg/mL): Active methylated cobalamin coenzyme required for methionine synthase activity and one-carbon homocysteine remethylation.
  • Pantothenic Acid / Vitamin B5 (25 mg/mL): Obligate biosynthetic precursor for Coenzyme A (CoA) and acyl-carrier protein (ACP), driving Krebs cycle turnover and fatty acid activation.
  • Pyridoxine HCl / Vitamin B6 (25 mg/mL): Pyridoxal 5′-phosphate (PLP) coenzyme precursor driving amino acid transamination and cystathionine β-synthase transsulfuration flux.
  • Lidocaine (1% / 10 mg/mL) & Benzyl Alcohol (0.9%): Voltage-gated sodium channel stabilizing agent and USP antimicrobial preservative system.

Batch-verified for exact quantitative concentration and chromatographic purity at Modern Aminos, Lipo-C + B12 w/ L-Carnitine is supplied in a sterile 20ML amber glass vial. Researchers evaluate this lipotropic standard alongside complementary bioenergetic and metabolic reference compounds available on the site, such as the NAD+ / Carnitine Based Amino Blend, standalone L-Carnitine 600mg/mL, NAD+, SLU-PP-332, and BAM15.

Formulation Profile & Concentration Data

Active Constituent Concentration (per mL) Total Content (20ML Vial) Primary Molecular Function
L-Carnitine Base 200 mg/mL 4,000 mg CPT-1/CPT-2 Mitochondrial Long-Chain Fatty Acid Shuttle & CRAT Buffering
L-Methionine 25 mg/mL 500 mg High-Density SAMe Precursor, Transmethylation, & Transsulfuration Substrate
L-Inositol (Myo-Inositol) 50 mg/mL 1,000 mg Phosphatidylinositol Precursor & IP3/DAG Second Messenger Architecture
Choline Bitartrate 50 mg/mL 1,000 mg Lipotropic Choline Donor & Phosphatidylcholine Synthesis Substrate
Methylcobalamin (Vitamin B12) 500 mcg/mL (0.5 mg/mL) 10,000 mcg (10 mg) Methionine Synthase Coenzyme & One-Carbon Homocysteine Remethylation
Pantothenic Acid (Vitamin B5) 25 mg/mL 500 mg Obligate Precursor for Coenzyme A (CoA) & Acyl-Carrier Protein (ACP) Synthesis
Pyridoxine HCl (Vitamin B6) 25 mg/mL 500 mg PLP Coenzyme for Transamination & Cystathionine β-Synthase Flux
Lidocaine 1% (10 mg/mL) 200 mg Voltage-Gated Sodium Channel Blocker & Membrane Stabilizing Agent
Benzyl Alcohol 0.9% (9 mg/mL) 180 mg USP Preservative Matrix for Multi-Draw Solution Stability

What are the Mechanisms of Action?

The biochemical pathways and cellular targets of Lipo-C + B12 w/ L-Carnitine in laboratory research include:

  • Mitochondrial Fatty Acid Transport & Beta-Oxidation: L-Carnitine acts as an obligate cofactor for carnitine palmitoyltransferase 1 (CPT-1) on the outer mitochondrial membrane, converting long-chain fatty acyl-CoA into acylcarnitine. Once translocated into the matrix via carnitine-acylcarnitine translocase (CACT), CPT-2 regenerates fatty acyl-CoA for beta-oxidation, while carnitine acetyltransferase (CRAT) buffers excess intramitochondrial acetyl-CoA to maintain Pyruvate Dehydrogenase (PDH) flux.
  • Coenzyme A (CoA) Biosynthesis & Acyl Transfer: Pantothenic Acid (B5) undergoes enzymatic phosphorylation via pantothenate kinase (PANK) to generate Coenzyme A. Active CoA is the universal acyl-carrier molecule required for both fatty acid beta-oxidation entry and the condensation of oxaloacetate into citrate within the Krebs cycle.
  • Lipotropic Export & Phospholipid Membrane Assembly: Choline Bitartrate and L-Inositol drive the synthesis of phosphatidylcholine and phosphatidylinositol, the primary structural phospholipids required for cellular membrane fluidity and the assembly of very-low-density lipoproteins (VLDL) responsible for lipid export.
  • Coordinated One-Carbon Transmethylation & Transsulfuration: High-density L-Methionine fuels the production of S-adenosylmethionine (SAMe). Methylcobalamin (B12) drives the continuous remethylation of homocysteine back to methionine, while Pyridoxine (B6) acts as a PLP-dependent cofactor for cystathionine β-synthase, shunting homocysteine into the transsulfuration pathway to synthesize reduced glutathione (GSH).

What do Preclinical & Academic Studies Show for Lipo-C Constituents?

When evaluating published scientific literature and bioenergetic monographs for the constituents of Lipo-C + B12 w/ L-Carnitine:

  • Carnitine Translocation & Fatty Acid Oxidation (PubMed): Landmark metabolic assays cataloged on PubMed (PMID: 21521252) confirm that high-density L-Carnitine availability upregulates CPT-1 enzyme velocity, accelerating long-chain fatty acid transport and beta-oxidation flux in tissue models.
  • Coenzyme A Biosynthesis & Metabolic Control (PubMed): Peer-reviewed monographs on PubMed (PMID: 15837837) detail how Pantothenic Acid (B5) availability directly dictates intracellular Coenzyme A concentrations, governing acyl-group transfer in lipid and carbohydrate metabolism.
  • Lipotropic Factors & Hepatic Lipid Export (PMC): Comprehensive cellular reviews archived in PMC (PMC3729018) document the synergistic action of Methionine, Inositol, and Choline in facilitating VLDL secretion and preventing intracellular lipid droplet accumulation.
  • Chemical Profiling & Identification (PubChem): Official structural characterizations maintained on PubChem for L-Carnitine (CID: 289), Pantothenic Acid (CID: 6072), and Methylcobalamin (CID: 54605976) verify exact molecular masses, CAS numbers, and chemical geometries.

How does Lipo-C + B12 w/ L-Carnitine compare to the NAD+ / Carnitine Amino Blend?

To evaluate multi-pathway formulation design, researchers compare Lipo-C + B12 w/ L-Carnitine against the NAD+ / Carnitine Based Amino Blend available at Modern Aminos:

Lipo-C + B12 w/ L-Carnitine vs. NAD+ / Carnitine Based Amino Blend

  • Lipo-C + B12 w/ L-Carnitine (Lipotropic & CoA Focus): Features a higher concentration of L-Methionine (25 mg/mL vs 10 mg/mL) and incorporates Pantothenic Acid (Vitamin B5, 25 mg/mL) to fuel Coenzyme A biosynthesis. Uses standard Choline Bitartrate (50 mg/mL) for direct lipotropic export and contains 200 mg/mL L-Carnitine with 1% Lidocaine. Ideal for modeling classical lipotropic transport, VLDL assembly, and CoA-dependent transmethylation.
  • NAD+ / Carnitine Based Amino Blend (Cellular Respiration & Bioenergetics Focus): Replaces Pantothenic Acid with direct β-NAD+ (20 mg/mL) to fuel mitochondrial Complex I electron transport, Sirtuin deacetylation, and PARP repair. Features a higher L-Carnitine concentration (250 mg/mL), 1.5% Lidocaine, and replaces Choline Bitartrate with CDP Choline (Citicoline, 50 mg/mL) to supply cytidine for advanced Kennedy-pathway phospholipid membrane biogenesis.
Formulation Parameter Lipo-C + B12 w/ L-Carnitine (20mL) NAD+ / Carnitine Amino Blend (20mL)
L-Carnitine Density 200 mg/mL (4,000 mg Total) 250 mg/mL (5,000 mg Total)
Primary Bioenergetic Driver Pantothenic Acid B5 (25 mg/mL → Coenzyme A Precursor) NAD+ (20 mg/mL → Complex I Electron Acceptor & Sirtuin Co-Substrate)
Choline Speciation Choline Bitartrate (50 mg/mL → Lipotropic Choline Salt) CDP Choline / Citicoline (50 mg/mL → Cytidine + Phosphocholine)
L-Methionine Content 25 mg/mL (500 mg Total → High-Capacity SAMe Pool) 10 mg/mL (200 mg Total → Balanced Methylation Pool)
L-Inositol Content 50 mg/mL (1,000 mg Total) 50 mg/mL (1,000 mg Total)
Methylcobalamin (B12) 500 mcg/mL (10 mg Total) 500 mcg/mL (10 mg Total)
Pyridoxine (B6) 25 mg/mL (500 mg Total) 25 mg/mL (500 mg Total)
Lidocaine Concentration 1.0% (10 mg/mL) 1.5% (15 mg/mL)
Primary Research Focus Classical lipotropic lipid export, VLDL assembly, CoA biosynthesis, and transmethylation flux Mitochondrial oxidative phosphorylation, direct Complex I respiration, sirtuin signaling, and phospholipid remodeling

Frequently Asked Questions (FAQs)

1. Is Modern Aminos a reliable place to buy Lipo-C + B12 w/ L-Carnitine?

Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and complex analytical formulations. Every batch of Lipo-C + B12 w/ L-Carnitine undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify exact concentration values for all active components, solution sterility, correct pH balance, and complete absence of heavy metals or microbial contaminants.

2. What is the composition of the Lipo-C + B12 w/ L-Carnitine liquid blend?

Each milliliter contains L-Carnitine (200 mg), L-Methionine (25 mg), L-Inositol (50 mg), Choline Bitartrate (50 mg), Methylcobalamin B12 (500 mcg), Pantothenic Acid B5 (25 mg), Pyridoxine B6 (25 mg), Lidocaine (1%), and Benzyl Alcohol (0.9%) pre-solubilized in an aqueous buffer.

3. What specific role does Pantothenic Acid (Vitamin B5) play in this matrix?

Pantothenic Acid is the essential precursor for Coenzyme A (CoA) synthesis. CoA is required to activate free fatty acids into fatty acyl-CoA esters, which are then transported into mitochondria by L-Carnitine for beta-oxidation.

4. Why does Lipo-C feature a higher concentration of L-Methionine (25 mg/mL)?

The elevated 25 mg/mL concentration of L-Methionine provides a high-capacity substrate pool for S-adenosylmethionine (SAMe) synthesis, maximizing cellular transmethylation potential and fueling the transsulfuration pathway toward glutathione production.

5. How does Lipo-C + B12 compare to the NAD+ / Carnitine Based Amino Blend?

Lipo-C focuses on classical lipotropic export and CoA synthesis via Pantothenic Acid (B5), Choline Bitartrate, and higher Methionine (25 mg/mL). The NAD+ / Carnitine blend focuses on direct mitochondrial respiration and sirtuin activation via NAD+ (20 mg/mL), CDP Choline, and higher L-Carnitine (250 mg/mL).

6. What are the functions of Lidocaine (1%) and Benzyl Alcohol (0.9%) in the formulation?

Lidocaine acts as a cellular membrane stabilizer and local sodium channel blocker in assay preparations, while Benzyl Alcohol (0.9%) serves as a USP-grade antimicrobial preservative maintaining solution integrity over multiple sampling draws.

7. How does Modern Aminos verify the identity and concentration of all constituents?

Modern Aminos uses multi-channel High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to resolve, identify, and quantify each active peak against authenticated reference standards prior to batch release.

8. What are the recommended storage protocols for the 20ML glass vial?

The 20ML glass vial should be stored tightly sealed under refrigerated conditions (2°C to 8°C) and protected from direct sunlight to maintain the long-term chemical stability of Methylcobalamin and B-complex vitamins in solution.

Disclaimer: All compounds and research materials provided by Modern Aminos are strictly for laboratory and research professional use only. They are not approved for human or animal use nor consumption by the Food and Drug Administration (FDA). These products should not be used for any form of in vivo experimentation or for any other non-laboratory purpose. Any violation or indication of human or animal use will result in immediate removal from being able to purchase products in the future. By purchasing these products, you acknowledge that they will be used exclusively within a controlled and qualified research environment.

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  • This product is not to be used as an active pharmaceutical ingredient (API) in compounding or manufacturing drugs for human or veterinary use.
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  • Modern Aminos does not condone or permit the use of its products for the development, testing, or production of illegal substances.

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Modern Aminos does not claim that this product is approved by the U.S. Food and Drug Administration (FDA) for any purpose. The statements regarding this product have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

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