GHK-Cu (Copper Tripeptide-1) is a high-affinity copper-chelating signal tripeptide engineered to modulate extracellular matrix (ECM) remodeling, stimulate dermal collagen synthesis, and support epidermal keratinocyte proliferation. Formulated in convenient, pre-measured 2MG dry-fill units (60 units per bottle / 120MG total), this format enables precise unit-dosing for microplate assays and benchtop cell culture screening without manual micro-weighing. For researchers exploring where to buy GHK-Cu peptide for in vitro tissue modeling or experimental GHK-Cu peptide serum preparations, Modern Aminos supplies this analytical-grade reference standard with verified copper stoichiometry and >99% chemical purity.
$109.00
In stock
| Quantity | Discounted Price |
|---|---|
| 4 - 6 | $104.64 |
| 7 - 9 | $102.46 |
| 10 + | $100.28 |
GHK-Cu (known chemically as Glycyl-L-histidyl-L-lysine copper complex or Copper Tripeptide-1) is an endogenous plasma tripeptide with an exceptionally high binding affinity for divalent copper ions (Cu2+). Operating as a master biological signaling molecule, this GHK peptide regulates extracellular matrix (ECM) remodeling, drives localized fibroblast collagen synthesis, and shifts cellular gene expression toward regenerative homeostasis and oxidative stress mitigation.
Among biological copper peptides, GHK-Cu is distinct in its dual functionality: it serves as a high-affinity copper transport carrier—supplying essential cofactors to enzymes like Cu/Zn Superoxide Dismutase (SOD1) and lysyl oxidase (LOX)—while directly modulating transcriptional networks across thousands of genes. In laboratory environments evaluating cutaneous repair mechanisms, GHK-Cu is frequently utilized as the active reference standard in experimental ghk-cu peptide serum formulations, epithelial barrier models, and fibroblast cell cultures.
For investigators researching where to buy ghk-cu peptide in convenient unit-dose formats, Modern Aminos supplies batch-verified, high-purity GHK-Cu peptide in pre-measured **2MG dry-fill solid units (60 units per bottle / 120MG total active content)**. This unit-dose format provides exact mass consistency, eliminating the weighing variance and atmospheric moisture absorption associated with handling bulk hygroscopic peptide powders during microplate assay setups.
Researchers evaluating cell-matrix interactions, enzymatic tissue remodeling, and genomic responses utilize GHK-Cu alongside complementary structural and cytoprotective reference standards available on the site, such as GHK-Cu, KPV, and Glutathione.
| Compound Name | GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper Complex) |
|---|---|
| Quantity / Formats Offered | 2MG Dry-Fill Solid Units (60 Units per Bottle / 120MG Total Content) |
| Peptide Sequence | Gly-His-Lys:Cu2+ |
| Synonyms / Alt Names | Copper Tripeptide-1, GHK Copper Complex, Glycyl-Histidyl-Lysine Copper(II), Copper Peptide |
| CAS Number | 49557-75-7 |
| Chemical Formula | C14H22CuN6O4 |
| Molecular Weight | 405.90 g/mol |
| IUPAC Name | copper(2+);2-[[2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-6-aminohexanoate |
| InChIKey | InChIKey=JXZAOBWUGMXXS-UHFFFAOYSA-N |
| SMILES Code | C(CCN)CC(C(=O)O)NC(=O)C(CC1=CN=CN1)NC(=O)CN.[Cu+2] |
The biochemical pathways and cellular targets of Copper Tripeptide-1 in laboratory research include:
When evaluating research efficacy and published scientific literature for GHK-Cu (Copper Tripeptide-1):
To select the appropriate copper peptide variant and physical format, researchers compare GHK-Cu against its closest structural analogs and alternative packaging types available at Modern Aminos:
| Compound / Reference | Chemical Class & Structure | Core Mechanism of Action | Research Focus & Profile |
|---|---|---|---|
| GHK-Cu (2MG Units) | Copper-Chelated Signal Tripeptide (Gly-His-Lys:Cu2+) | Upregulates collagen I/III and elastin; modulates MMP/TIMP balance; delivers copper to SOD1/LOX | Unit-dose dermal/epidermal repair, fibroblast migration, genomic resetting, and microplate assays |
| AHK-Cu | Alanine-Histidine-Lysine Copper Complex | Upregulates VEGF and downregulates TGF-β1 specifically in dermal papilla cells | Hair follicle bioenergetics, anagen phase prolongation, and follicular matrix modeling |
| Pal-GHK | Palmitoyl Tripeptide-1 (Lipid Conjugate; No Copper) | Stimulates collagen and GAG synthesis via the native GHK peptide sequence; enhanced lipid diffusion | Hydrophobic topical matrix modeling; relies on peptide signaling without copper enzyme activation |
| Pentadecapeptide Arginate | Synthetic Gastric Pentadecapeptide Arginate | Activates VEGFR2, stimulates focal adhesion kinase (FAK), and drives microvascular angiogenesis | Mucosal barrier protection, tenocyte outgrowth, and microvascular sprouting via growth factor pathways |
Yes. For researchers wondering where to buy GHK-Cu peptide, Modern Aminos is a highly trusted vendor for high-purity copper peptides. Every batch of 2MG dry-fill units undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ chemical purity, correct copper chelation stoichiometry, and complete absence of unreacted peptide fragments or heavy metal impurities.
GHK-Cu (Copper Tripeptide-1) is a naturally occurring, high-affinity copper-chelating signal peptide composed of the amino acids glycine, histidine, and lysine bound to a divalent copper ion (Cu2+). It functions as a master regulator of extracellular matrix remodeling, collagen synthesis, and genomic transcription.
In dermal fibroblasts, GHK-Cu stimulates robust synthesis of collagen types I & III, elastin, and glycosaminoglycans while balancing MMP/TIMP enzymes. In epidermal and epithelial cells, it accelerates keratinocyte migration, upregulates integrins and p63 to preserve basal stem cell populations, and protects epithelial barrier structures from oxidative free-radical damage.
GHK-Cu contains glycine at the N-terminus and chelates copper to drive broad-spectrum dermal/epidermal matrix repair. AHK-Cu substitutes glycine for alanine to specifically target dermal papilla cells in hair follicle research. Pal-GHK conjugates a palmitic fatty acid chain to the peptide to enhance lipid membrane penetration, but lacks copper chelation entirely.
Pre-measured 2MG dry-fill units (60 count per bottle) eliminate the need to weigh milligram-scale hygroscopic powders on analytical balances. Researchers can cleanly dispense exact 2MG increments directly into assay wells, ensuring strict volumetric precision and minimizing waste.
Yes. In laboratory protocols, single 2MG units can be dissolved into defined volumes of sterile laboratory buffers or topical carrier matrices to create an experimental GHK-Cu peptide serum of precise concentration for in vitro skin model testing.
Modern Aminos uses High-Performance Liquid Chromatography (HPLC) to confirm sequence purity exceeding 99% and Mass Spectrometry (MS) to verify the exact molecular weight (405.90 g/mol) and 1:1 copper-to-peptide stoichiometry prior to batch release.
GHK-Cu 2MG dry-fill units bottles should be stored tightly sealed in a cool, dry environment (15°C to 25°C) protected from direct sunlight, light exposure, and atmospheric moisture. Under controlled room temperature conditions, GHK-Cu maintains complete solid-state chemical stability throughout its designated shelf life.
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